Trial · NCT07889050
Effect of Intracanal Cryotherapy on Pain, Anxiety, and Salivary Irisin After Root Canal Treatment
NCT07889050, Not applicable, Not yet recruiting, Alanya Alaaddin Keykubat University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Intracanal Cryotherapy on Pain, Anxiety, and Salivary Irisin After Root Canal Treatment. Trials, record NCT07889050. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07889050
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Intracanal Cryotherapy on Pain, Anxiety, and Salivary Irisin After Root Canal Treatment
- NCT number
- NCT07889050
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 130 participants, estimated
- Lead sponsor
- Alanya Alaaddin Keykubat University
- Conditions
- Postoperative Pain After Endodontic Treatment, Dental Anxiety, Root Canal Treatment
- Interventions
- Intracanal cryotherapy, Standard room-temperature irrigation
- First posted
- 2026-10-22
- Last updated
- 2026-10-28
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Postoperative pain assessed by Visual Analog Scale (VAS) | 24 hours after root canal treatment | Postoperative pain will be self-assessed by participants using a 100 mm Visual Analog Scale (VAS), consisting of a horizontal line where participants mark the point that best represents their level of pain intensity. The left end (0 mm) indicates "no pain" and the right end (100 mm) indicates "the most severe pain I have ever felt in my life." Scores are measured in millimeters, with higher scores indicating greater pain intensity. Participants will record their VAS score in a standardized pain diary at each assessment time point, along with any rescue analgesic (paracetamol 500 mg) use, including time and dose, and any adverse events or unexpected occurrences. A blinded researcher, unaware of group allocation, will telephone participants at each designated time point to record pain scores and remind them to complete the diary. |
| Secondary | Postoperative pain assessed by Visual Analog Scale (VAS) at 6 Hours | 6 hours after root canal treatment | Postoperative pain will be self-assessed using a 100 mm Visual Analog Scale (VAS). The left end (0 mm) indicates "no pain" and the right end (100 mm) indicates "the most severe pain I have ever felt in my life." Higher scores indicate greater pain intensity. |
| Secondary | Postoperative pain assessed by Visual Analog Scale (VAS) at 12 Hours | 12 hours after root canal treatment | Postoperative pain will be self-assessed using a 100 mm Visual Analog Scale (VAS). The left end (0 mm) indicates "no pain" and the right end (100 mm) indicates "the most severe pain I have ever felt in my life." Higher scores indicate greater pain intensity. |
| Secondary | Postoperative pain assessed by Visual Analog Scale (VAS) at 48 Hours | 48 hours after root canal treatment | Postoperative pain will be self-assessed using a 100 mm Visual Analog Scale (VAS). The left end (0 mm) indicates "no pain" and the right end (100 mm) indicates "the most severe pain I have ever felt in my life." Higher scores indicate greater pain intensity. |
| Secondary | Postoperative pain assessed by Visual Analog Scale (VAS) at 72 Hours | 72 hours after root canal treatment | Postoperative pain will be self-assessed using a 100 mm Visual Analog Scale (VAS). The left end (0 mm) indicates "no pain" and the right end (100 mm) indicates "the most severe pain I have ever felt in my life." Higher scores indicate greater pain intensity. |
| Secondary | Postoperative pain assessed by Visual Analog Scale (VAS) at 7 Days | 7 days (168 hours) after root canal treatment | Postoperative pain will be self-assessed using a 100 mm Visual Analog Scale (VAS). The left end (0 mm) indicates "no pain" and the right end (100 mm) indicates "the most severe pain I have ever felt in my life." Higher scores indicate greater pain intensity. |
| Secondary | Pain Catastrophizing as Assessed by Pain Catastrophizing Scale (PCS) | Baseline, prior to root canal treatment | Pain catastrophizing will be assessed using the Pain Catastrophizing Scale (PCS), a validated self-report questionnaire measuring the tendency to exaggerate the threat value of pain. Higher scores indicate greater pain catastrophizing. |
| Secondary | Dental anxiety assessed by Modified Dental Anxiety Scale (MDAS) | Baseline, prior to root canal treatment | Dental anxiety will be assessed using the Modified Dental Anxiety Scale (MDAS), a validated self-report questionnaire measuring anxiety related to dental treatment. Higher scores indicate greater dental anxiety. |
| Secondary | Salivary irisin level at baseline | Baseline, prior to root canal treatment | Salivary irisin concentration will be measured in unstimulated saliva samples collected using the passive drooling method, analyzed by enzyme-linked immunosorbent assay (ELISA). |
| Secondary | Salivary irisin level at 24 Hours | 24 hours after root canal treatment | Salivary irisin concentration will be measured in unstimulated saliva samples collected using the passive drooling method, analyzed by enzyme-linked immunosorbent assay (ELISA). |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07889050
GET https://conductscience.org/api/trials/v1/NCT07889050/registered