Trial · NCT07894393
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 17 of 17
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Cardiac index | 10 minutes after endotracheal intubation | Cardiac index (L/min/m2) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line, compared between the four wash-in groups. |
| Secondary | Systolic arterial pressure | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Systolic arterial pressure (mmHg) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Diastolic arterial pressure | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Diastolic arterial pressure (mmHg) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Mean arterial pressure | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Mean arterial pressure (mmHg) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Heart rate | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Heart rate (beats/min) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Cardiac index at other time points | Before induction (T0), 30 seconds after intubation (T1) and when 0.8 MAC is reached (T2) | Cardiac index (L/min/m2) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Stroke volume index | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Stroke volume index (mL/m2) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Pulse pressure variation | 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Pulse pressure variation (%) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. Not assessed at T0 because patients were breathing spontaneously. |
| Secondary | Cardiac cycle efficiency | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Cardiac cycle efficiency (unitless index, range -1 to +1) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Maximum rate of arterial pressure rise (dP/dt) | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Maximum rate of rise of the radial arterial pressure, dP/dt (mmHg/ms) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Arterial elastance | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Arterial elastance (mmHg/mL) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Cardiac power index | Before induction (T0), 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | Cardiac power index (W/m2) measured with the pressure recording analytical method (PRAM; MostCare Up) via a radial arterial line. At each time point, the highest value among five consecutive beats was recorded. |
| Secondary | Wash-in duration | From start of sevoflurane delivery until 0.8 MAC is reached (up to 10 minutes after intubation) | Time (seconds) from the start of sevoflurane delivery after intubation until the age-adjusted MAC displayed by the anaesthesia workstation reaches 0.8. |
| Secondary | Cumulative sevoflurane consumption | When 0.8 MAC is reached and 10 minutes after intubation | Cumulative liquid sevoflurane consumption (mL) as reported numerically by the anaesthesia workstation. |
| Secondary | Number of participants requiring ephedrine | From induction of anaesthesia to 10 minutes after intubation | Number of participants who received at least one 10-mg intravenous bolus of ephedrine for hypotension, defined as mean arterial pressure \<65 mmHg or a decrease \>30% from baseline. |
| Secondary | Time to first ephedrine administration | From induction of anaesthesia to 10 minutes after intubation | Time (seconds) from induction of anaesthesia to the first intravenous ephedrine bolus given for hypotension (mean arterial pressure \<65 mmHg or a decrease \>30% from baseline). |
| Secondary | State entropy | 30 seconds after intubation (T1), when 0.8 MAC is reached (T2) and 10 minutes after intubation (T3) | State entropy (units on a scale, 0-91) measured with the GE Entropy module; lower values indicate deeper hypnosis. |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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