Trial · NCT07896954
A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty
NCT07896954, Not applicable, Recruiting, Chang Gung Memorial Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty. Trials, record NCT07896954. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07896954
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty
- NCT number
- NCT07896954
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 120 participants, estimated
- Lead sponsor
- Chang Gung Memorial Hospital
- Conditions
- Pain (Knee), Pain and Anxiety, TKA
- Interventions
- Heart rate variability biofeedback, Mindfulness, psychoeducation
- First posted
- 2026-10-27
- Last updated
- 2026-10-27
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Visual Analogue Scale change | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | Subjective post-surgical pain. Using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the "no pain" anchor and the patient's mark, providing a range of scores from 0-100. A higher score indicates greater pain intensity. |
| Primary | Pittsburgh Sleep Quality Index (PSQI) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | The global PSQI score is then calculated by totaling the seven component scores, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality. |
| Primary | Hospital Anxiety and Depression Scale (HADS) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | HADS measures anxiety and depression in the medical setting. Higher scores indicate greater anxiety and depression. |
| Primary | EuroQol-5D questionnaire (EQ-5D) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | EQ-5D-5L is a standardized measure of health-related quality of life. The higher transformed scores, the better HRQoL. |
| Secondary | Visual Analogue Scale for Anxiety (VAS-A) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | Subjective anxiety rated on a 100-mm line from 0 (no anxiety) to 100 (worst imaginable anxiety). Higher scores indicate greater anxiety. |
| Secondary | Heart rate variability (HRV) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | Time-domain (SDNN, RMSSD) and frequency-domain (LF, HF power) HRV indices derived from short-term ECG/PPG recordings. Higher RMSSD and HF indicate greater parasympathetic activity. |
| Secondary | Knee injury and Osteoarthritis Outcome Score (KOOS) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | Patient-reported knee function across five subscales (pain, symptoms, activities of daily living, sport/recreation, knee-related quality of life), each scored 0-100. Higher scores indicate better function. |
| Secondary | Knee range of motion (ROM) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | Active knee flexion and extension measured in degrees with a goniometer. Larger flexion range indicates better knee mobility. |
| Secondary | Manual muscle testing (MMT) of hamstrings and quadriceps | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | Hamstring and quadriceps strength graded on the 0-5 manual muscle testing scale. Higher grades indicate greater muscle strength. |
| Secondary | Timed Up and Go Test (TUG) | Baseline (preoperative) and at 2, 6, and 12 weeks after surgery | Time (seconds) to rise from a chair, walk 3 meters, turn, walk back and sit down. Shorter times indicate better functional mobility. |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07896954
GET https://conductscience.org/api/trials/v1/NCT07896954/registered