Trial · NCT07904325
Vascular Health and Function in Cystic Fibrosis
NCT07904325, Not yet recruiting, Liverpool Heart and Chest Hospital NHS Foundation Trust
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Vascular Health and Function in Cystic Fibrosis. Trials, record NCT07904325. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07904325
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Vascular Health and Function in Cystic Fibrosis
- NCT number
- NCT07904325
- Status
- Not yet recruiting
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
- Conditions
- Cystic Fibrosis, Endothelial Dysfunction, Cardiovascular Risk Factor
- Interventions
- Non-invasive vascular, cerebrovascular and autonomic assessment
- First posted
- 2026-10-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Radial artery flow-mediated dilation (FMD) | Single study visit (Day 1) | Percentage change in radial artery diameter |
| Primary | Radial artery low-flow mediated constriction (L-FMC) | Single study visit (Day 1) | Percentage change in radial artery diameter |
| Secondary | Carotid artery reactivity (CAR) | Single study visit (Day 1) | Percentage change in common carotid artery diameter from 1 minute of rest to the peak response during 3 minutes of hand immersion in iced water (4 degrees C or below; cold pressor test), measured by high-resolution ultrasound. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Carotid intima-media thickness (IMT) | Single study visit (Day 1) | Mean common carotid artery intima-media thickness (mm), measured bilaterally by B-mode ultrasound approximately 1 cm proximal to the carotid bulb in anterior, lateral and posterior views. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Cerebral neurovascular coupling | Single study visit (Day 1) | Change in cerebral artery mean blood flow velocity (transcranial Doppler) in response to a standard visual stimulation protocol (alternating 30-second eyes open and eyes closed periods), expressed as percentage increase from eyes-closed baseline. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Cerebral autoregulation (spontaneous and dynamic) | Single study visit (Day 1) | Relationship between beat-to-beat blood pressure and cerebral artery mean blood flow velocity (transcranial Doppler), assessed during 10 minutes of supine rest (spontaneous) and during 5 minutes of repeated 10-second squat-stand manoeuvres (dynamic), with continuous ECG and end-tidal gas monitoring. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Baroreflex sensitivity and baroreflex effectiveness index | Single study visit (Day 1) | Cardiac baroreflex sensitivity (ms/mmHg) and baroreflex effectiveness index derived from continuous ECG and beat-to-beat finger blood pressure, during 10 minutes of supine rest (spontaneous) and during 5 minutes of repeated 10-second squat-stand manoeuvres (dynamic). Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Cognitive function | Single study visit (Day 1) | Cognitive performance assessed by the Standardised Mini-Mental State Examination (total score 0 to 30; higher scores indicate better cognitive function), the Wisconsin Card Sorting Task (e.g. categories completed and perseverative errors) and a Lexical Decision Task (accuracy and reaction time). Compared between adults with CF and age/sex matched healthy controls, and examined for association with neurovascular coupling. |
| Secondary | Anxiety and depression (Hospital Anxiety and Depression Scale) | Single study visit (Day 1) | Hospital Anxiety and Depression Scale anxiety and depression subscale scores (each 0 to 21; higher scores indicate more severe symptoms). Compared between adults with CF and age/sex matched healthy controls, and examined for association with neurovascular coupling. |
| Other | Health-related quality of life | Single study visit (Day 1) | Health-related quality of life assessed EQ-5D-5L (index value and visual analogue scale 0 to 100; higher scores indicate better health). Compared between adults with CF and age/sex matched healthy controls. |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Card Sorting Test (Berg) | Secondary outcome | ConductCognition |
| Lexical Decision Task | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07904325
GET https://conductscience.org/api/trials/v1/NCT07904325/registered