Trial · NCT07904325
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 12 of 12
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Radial artery flow-mediated dilation (FMD) | Single study visit (Day 1) | Percentage change in radial artery diameter |
| Primary | Radial artery low-flow mediated constriction (L-FMC) | Single study visit (Day 1) | Percentage change in radial artery diameter |
| Secondary | Carotid artery reactivity (CAR) | Single study visit (Day 1) | Percentage change in common carotid artery diameter from 1 minute of rest to the peak response during 3 minutes of hand immersion in iced water (4 degrees C or below; cold pressor test), measured by high-resolution ultrasound. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Carotid intima-media thickness (IMT) | Single study visit (Day 1) | Mean common carotid artery intima-media thickness (mm), measured bilaterally by B-mode ultrasound approximately 1 cm proximal to the carotid bulb in anterior, lateral and posterior views. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Cerebral neurovascular coupling | Single study visit (Day 1) | Change in cerebral artery mean blood flow velocity (transcranial Doppler) in response to a standard visual stimulation protocol (alternating 30-second eyes open and eyes closed periods), expressed as percentage increase from eyes-closed baseline. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Cerebral autoregulation (spontaneous and dynamic) | Single study visit (Day 1) | Relationship between beat-to-beat blood pressure and cerebral artery mean blood flow velocity (transcranial Doppler), assessed during 10 minutes of supine rest (spontaneous) and during 5 minutes of repeated 10-second squat-stand manoeuvres (dynamic), with continuous ECG and end-tidal gas monitoring. Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Baroreflex sensitivity and baroreflex effectiveness index | Single study visit (Day 1) | Cardiac baroreflex sensitivity (ms/mmHg) and baroreflex effectiveness index derived from continuous ECG and beat-to-beat finger blood pressure, during 10 minutes of supine rest (spontaneous) and during 5 minutes of repeated 10-second squat-stand manoeuvres (dynamic). Compared between adults with CF and age/sex matched healthy controls. |
| Secondary | Cognitive function | Single study visit (Day 1) | Cognitive performance assessed by the Standardised Mini-Mental State Examination (total score 0 to 30; higher scores indicate better cognitive function), the Wisconsin Card Sorting Task (e.g. categories completed and perseverative errors) and a Lexical Decision Task (accuracy and reaction time). Compared between adults with CF and age/sex matched healthy controls, and examined for association with neurovascular coupling. |
| Secondary | Anxiety and depression (Hospital Anxiety and Depression Scale) | Single study visit (Day 1) | Hospital Anxiety and Depression Scale anxiety and depression subscale scores (each 0 to 21; higher scores indicate more severe symptoms). Compared between adults with CF and age/sex matched healthy controls, and examined for association with neurovascular coupling. |
| Other | Health-related quality of life | Single study visit (Day 1) | Health-related quality of life assessed EQ-5D-5L (index value and visual analogue scale 0 to 100; higher scores indicate better health). Compared between adults with CF and age/sex matched healthy controls. |
| Other | Association between inflammatory/oxidative stress markers and vascular and autonomic function in CF | Single study visit (Day 1) | In participants with CF, regression analysis of the association between blood markers of inflammation and oxidative stress and measures of peripheral vascular function (FMD, L-FMC, carotid artery reactivity), cerebrovascular function (neurovascular coupling, cerebral autoregulation) and baroreflex function. |
| Other | Health-related quality of life | Single study visit (Day 1) | Health-related quality of life assessed by the RAND 36-Item Health Survey. Compared between adults with CF and age/sex matched healthy controls. |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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