ConductScience.org, home

85,013 comparisons from ClinicalTrials.gov. Counted 2026-11-10.

85,013 comparisons

Most participants first33,758 with no events in either group come last1,141 to 1,160 of 85,013

Show the results as
ComparisonWith the outcomeRisk difference, 95% intervalParticipantsTrial
LCZ696 vs Enalapril: Number of Patients - All-cause Mortality711 of 4,187

835 of 4,212

-2.8 points

-4.5 to -1.2

8,399NCT01035255

This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure

Standard Implementation Strategy Period vs Enhanced Contact Investigation Intervention Period: Number of Contacts Initiating TB Preventative Therapy122 of 2,829

264 of 5,560

-0.4 points

-1.3 to 0.5

8,389NCT05640648

Human-centered Design and Communities of Practice to Improve Home-based Tuberculosis Contact Investigation in Uganda

Standard Implementation Strategy Period vs Enhanced Contact Investigation Intervention Period: Initiation of TB Preventative Therapy122 of 2,829

264 of 5,560

-0.4 points

-1.3 to 0.5

8,389NCT05640648

Human-centered Design and Communities of Practice to Improve Home-based Tuberculosis Contact Investigation in Uganda

Simvastatin Plus Ezetimibe vs Placebo: Major Vascular Events Analyzed Amongst Patients Initially Randomized to Simvastatin Plus Ezetimibe Versus Placebo (Original Protocol-defined Primary Outcome)639 of 4,193

749 of 4,191

-2.6 points

-4.2 to -1.0

8,384NCT00125593

Study of Heart and Renal Protection

HEPLISAV vs Engerix-B: serious adverse events345 of 5,587

148 of 2,781

0.9 points

-0.2 to 1.9

8,368NCT02117934

Safety and Immunogenicity Study of the Hepatitis B Vaccine, HEPLISAV™, Compared to Engerix-B® Vaccine

Heparin/Edoxaban Tosylate vs Heparin/Warfarin: serious adverse events801 of 4,118

852 of 4,122

-1.2 points

-2.9 to 0.5

8,240NCT00986154

Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study).

Omecamtiv Mecarbil vs Placebo: deaths from any cause1,078 of 4,120

1,078 of 4,112

-0.1 points

-2.0 to 1.8

8,232NCT02929329

Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction

Dutasteride 0.5 mg vs Placebo: serious adverse events748 of 4,105

837 of 4,126

-2.1 points

-3.8 to -0.4

8,231NCT00056407

"REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk

Omecamtiv Mecarbil vs Placebo: serious adverse events2,373 of 4,110

2,435 of 4,101

-1.6 points

-3.8 to 0.5

8,211NCT02929329

Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction

Tafamidis Treated-Overall vs Tafamidis Untreated-Overall: Number of All-Cause Deaths158 of 2,521

1,038 of 5,686

-12.0 points

-13.3 to -10.6

8,207NCT00628745

Transthyretin Amyloidosis Outcome Survey (THAOS)

AMR101 vs Placebo: Total Mortality.274 of 4,089

310 of 4,090

-0.9 points

-2.0 to 0.2

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: Unstable Angina Determined to be Caused by Myocardial Ischemia by Invasive / Non-invasive Testing and Requiring Emergent Hospitalization.108 of 4,089

157 of 4,090

-1.2 points

-2.0 to -0.4

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: Total Mortality, Nonfatal MI (Including Silent MI), or Nonfatal Stroke.549 of 4,089

690 of 4,090

-3.4 points

-5.0 to -1.9

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: Fatal or Nonfatal Stroke.98 of 4,089

134 of 4,090

-0.9 points

-1.6 to -0.2

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: Fatal or Nonfatal MI (Including Silent MI).250 of 4,089

355 of 4,090

-2.6 points

-3.7 to -1.4

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: CV Death.174 of 4,089

213 of 4,090

-1.0 points

-1.9 to -0.0

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: Composite of CV Death, Nonfatal MI (Including Silent MI), or Nonfatal Stroke.459 of 4,089

606 of 4,090

-3.6 points

-5.0 to -2.1

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: Composite of CV Death or Nonfatal MI (Including Silent MI).392 of 4,089

507 of 4,090

-2.8 points

-4.2 to -1.5

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: Non-elective Coronary Revascularization Represented as the Composite of Emergent or Urgent Classifications.216 of 4,089

321 of 4,090

-2.6 points

-3.6 to -1.5

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

AMR101 vs Placebo: deaths from any cause274 of 4,089

310 of 4,090

-0.9 points

-2.0 to 0.2

8,179NCT01492361

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

Request

GET /api/comparisons/v1

Words from a trial's title, conditions or interventions, its outcome or its groups, or an NCT number.

An outcome counted in participants, the serious adverse events, or the deaths from any cause.

No key needed

Response

The first 2 of this page's 20 results. GET /api/comparisons/v1?page=58

{
  "data": {
    "total": 85013,
    "results": [
      {
        "id": "NCT01035255-c1d0a2ad",
        "title": "LCZ696 vs Enalapril: Number of Patients - All-cause Mortality",
        "summary": "711 of 4187 against 835 of 4212; risk difference -2.8 points, 95% interval -4.5 to -1.2; NCT01035255, This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure",
        "record": "/library/comparisons/NCT01035255-c1d0a2ad",
        "nct_id": "NCT01035255",
        "kind": "outcome",
        "participants": 8399,
        "risk_difference": {
          "value": -0.02843179415506461,
          "lower": -0.04498840150213024,
          "upper": -0.011859260840896425
        },
        "group_1": "711 of 4,187",
        "group_2": "835 of 4,212",
        "difference": "-2.8 points",
        "interval": "-4.5 to -1.2",
        "trial_title": "This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure"
      },
      {
        "id": "NCT05640648-51e37c9d",
        "title": "Standard Implementation Strategy Period vs Enhanced Contact Investigation Intervention Period: Number of Contacts Initiating TB Preventative Therapy",
        "summary": "122 of 2829 against 264 of 5560; risk difference -0.4 points, 95% interval -1.3 to 0.5; NCT05640648, Human-centered Design and Communities of Practice to Improve Home-based Tuberculosis Contact Investigation in Uganda",
        "record": "/library/comparisons/NCT05640648-51e37c9d",
        "nct_id": "NCT05640648",
        "kind": "outcome",
        "participants": 8389,
        "risk_difference": {
          "value": -0.004357235314611511,
          "lower": -0.013431552495882291,
          "upper": 0.005335548488621923
        },
        "group_1": "122 of 2,829",
        "group_2": "264 of 5,560",
        "difference": "-0.4 points",
        "interval": "-1.3 to 0.5",
        "trial_title": "Human-centered Design and Communities of Practice to Improve Home-based Tuberculosis Contact Investigation in Uganda"
      }
    ],
    "no_events": 33758,
    "columns": [
      {
        "key": "title",
        "label": "Comparison"
      },
      {
        "key": "group_1",
        "label": "With the outcome",
        "under": "group_2"
      },
      {
        "key": "difference",
        "label": "Risk difference, 95% interval",
        "under": "interval"
      },
      {
        "key": "participants",
        "label": "Participants"
      },
      {
        "key": "nct_id",
        "label": "Trial",
        "under": "trial_title"
      }
    ],
    "order": "Most participants first",
    "kinds": {
      "all": 85013,
      "outcome": 33568,
      "serious-adverse-events": 31897,
      "deaths": 19548
    }
  },
  "release": "trial-comparisons-2026-03-23-0.1.0",
  "terms": [
    {
      "source": "ClinicalTrials.gov's posted results, through CTTI's AACT",
      "license": "ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "Freely available. Acknowledgement requested"
    },
    {
      "source": "ClinicalTrials.gov",
      "license": "none stated",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "None stated"
    }
  ],
  "next": "/api/comparisons/v1?page=59",
  "request_id": "q0ecgApcbH3OLRAD"
}
trial-comparisons-2026-03-23-0.1.0Next page

Sources 2

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

Genes

NCBI Gene

One gene with its proteins, patents, drugs, trials, grants and papers.

Open193,990 genes2026-11-11

Trials

ClinicalTrials.gov

Search clinical trials by condition, drug, outcome or NCT number, with the results each one posted.

Open611,552 trials2026-11-12

Sequences

Patent publications

Paste a sequence and see the patents that disclose it.

For invited accounts.

Opens sequences.conductscience.org

By invitation39,249,078 sequences2026-11-05

For software

Read Trial comparisons from software.

Every answer on this page is also JSON, under /api/comparisons/v1. No key.

GET https://conductscience.org/api/comparisons/v1?q=placebo%20heart%20failure&kind=outcome

Ask an assistant

  • In FOURIER, how did serious adverse events compare between evolocumab and placebo?
  • Which metformin trials reported deaths, and what was the risk difference?
  • What was the number needed to treat for HELIOS-B's composite outcome?
  • Which placebo-controlled heart failure trials had the most participants?