Disease · MONDO_0000440
metabolic acidosis
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. metabolic acidosis. Diseases, record MONDO_0000440. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0000440
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs11
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| SODIUM BICARBONATE | CHEMBL1353 | Small molecule | Approval | TTD | 8 | 7 | 7 | Drugs and targets |
| VEVERIMER | CHEMBL4298196 | Small molecule | Phase 3 | ClinicalTrials.gov | 5 | 5 | 5 | Drugs and targets |
| DEXTROSE | CHEMBL1222250 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SODIUM LACTATE | CHEMBL1357 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| SODIUM ZIRCONIUM CYCLOSILICATE | CHEMBL3301592 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| MEGLUMINE | CHEMBL1200570 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| POTASSIUM CITRATE | CHEMBL3989822 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SODIUM SUCCINATE | CHEMBL1200345 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| AIR, MEDICAL | CHEMBL2108889 | Unknown | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets | |
| OXYGEN | CHEMBL1234886 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
1 to 10 of 11
See all 11 drugsTargets0
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
None in this release.
Trials16
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03317444 | Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease | Phase 3 | 217 | 2021-04-26 | Metabolic Acidosis | VEVERIMER | Its record names the disease | ClinicalTrials.gov |
| NCT03390842 | Long-term Safety Extension to Study TRCA-301 | Phase 3 | 196 | 2021-10-22 | Metabolic Acidosis | VEVERIMER | Its record names the disease | ClinicalTrials.gov |
| NCT02809183 | Evaluation of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis | Phase 1/2 | 135 | 2020-01-14 | Acidosis | VEVERIMER | Its record names the disease | ClinicalTrials.gov |
| NCT02741284 | Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings | Not applicable | 114 | 2018-11-02 | Electronic Fetal Monitoring, Fetal Hypoxia, Fetal-Placental Circulation | OXYGEN | Its record names the disease | ClinicalTrials.gov |
| NCT04727528 | Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease | Phase 3 | 39 | 2023-10-06 | Hyperkalaemia, Metabolic Acidosis, Chronic Kidney Disease | SODIUM ZIRCONIUM CYCLOSILICATE | Its record names the disease | ClinicalTrials.gov |
| NCT04600323 | Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD | Early phase 1 | 34 | 2024-12-20 | Metabolic Acidosis, Chronic Kidney Disease, Cognitive Dysfunction | SODIUM BICARBONATE | Its record names the disease | ClinicalTrials.gov |
| NCT02031770 | Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease | Not applicable | 20 | 2020-09-22 | Metabolic Acidosis, Chronic Kidney Disease | SODIUM BICARBONATE | Its record names the disease | ClinicalTrials.gov |
| NCT03710291 | Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis | Phase 3 | 1,480 | Metabolic Acidosis, Chronic Kidney Disease | VEVERIMER | Its record names the disease | ClinicalTrials.gov | |
| NCT04953013 | Risk Potential for Organ Dysfunction Associated With Sodium Bicarbonate Therapy (SBT) in Critically Ill Patients | 664 | Metabolic Acidosis; Critically Ill Patients; Organ Dysfunction | SODIUM BICARBONATE | Its record names the disease | ClinicalTrials.gov | ||
| NCT05697770 | SODium BICarbonate for Metabolic Acidosis in the ICU | Phase 3 | 500 | Metabolic Acidosis, Shock | DEXTROSE, SODIUM BICARBONATE | Its record names the disease | ClinicalTrials.gov |
1 to 10 of 16
See all 16 trialsComparisons in its trials10
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| TRC101 Treatment Arm vs Placebo Treatment Arm: deaths from any cause | 0 of 124 | 2 of 93 | 217 | NCT03317444 | Trial comparisons |
| TRC101 Treatment Arm vs Placebo Treatment Arm: serious adverse events | 3 of 124 | 2 of 93 | 217 | NCT03317444 | Trial comparisons |
| TRC101 Treatment Arm vs Placebo Treatment Arm: deaths from any cause | 0 of 112 | 2 of 81 | 193 | NCT03390842 | Trial comparisons |
| TRC101 Treatment Arm vs Placebo Treatment Arm: serious adverse events | 2 of 112 | 4 of 81 | 193 | NCT03390842 | Trial comparisons |
| No Oxygen vs Oxygen: Number of Patients With Resolved Recurrent Decelerations | 49 of 57 | 43 of 57 | 114 | NCT02741284 | Trial comparisons |
| Room Air vs Oxygen: deaths from any cause | 0 of 57 | 0 of 57 | 114 | NCT02741284 | Trial comparisons |
| Room Air vs Oxygen: serious adverse events | 0 of 57 | 0 of 57 | 114 | NCT02741284 | Trial comparisons |
| Treatment vs Control: serious adverse events | 0 of 20 | 0 of 20 | 40 | NCT02031770 | Trial comparisons |
| Sodium Bicarbonate vs Placebo: deaths from any cause | 0 of 18 | 0 of 16 | 34 | NCT04600323 | Trial comparisons |
| Sodium Bicarbonate vs Placebo: serious adverse events | 6 of 18 | 7 of 16 | 34 | NCT04600323 | Trial comparisons |
Papers from its trials14
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0000440
GET https://conductscience.org/api/diseases/v1/MONDO_0000440/drugs