Disease · MONDO_0006957

root caries

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. root caries. Diseases, record MONDO_0006957. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0006957

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: root caries; Open Targets
Open Targets ID: MONDO_0006957; Open Targets
Other names: Cementum caries (disorder), cementum dental caries, dental caries of cementum, dental caries of root surface; Open Targets
Disease Ontology: DOID:14089; Disease Ontology
MeSH: D017213; MeSH
Highest stage of its drugs: Phase 1/2, for 1 of its 5 drugs, from ClinicalTrials.gov; Open Targets

Drugs5

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
FLUORIDE	CHEMBL1232767	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
DURAPATITE	CHEMBL2218916	Small molecule	Phase 1	ClinicalTrials.gov	1	1	0	Drugs and targets
SILVER DIAMMINE FLUORIDE	CHEMBL4297206	Small molecule	Early phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
SODIUM FLUORIDE	CHEMBL1528	Small molecule	Early phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
LACTIC ACID	CHEMBL1200559	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets

Targets0

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

None in this release.

Trials2

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02647203	Non-invasive Treatment of Root Caries in Older Adults	Phase 1/2	345	2021-01-05	Root Caries	FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT04255251	Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults	Early phase 1	200		Caries Roots, Flouride Varnish, Caries; Dentin, Caries Arrested	SILVER DIAMMINE FLUORIDE, SODIUM FLUORIDE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
High Fluoride Toothpaste vs Standard Fluoride Toothpaste: deaths from any cause	0 of 142	0 of 138	280	NCT02647203	Trial comparisons
High Fluoride Toothpaste vs Standard Fluoride Toothpaste: serious adverse events	0 of 142	0 of 138	280	NCT02647203	Trial comparisons

Papers from its trials3

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
31299955	RESULT	1	PubMed
25091189	RESULT	1	PubMed
31176788	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0006957

GET https://conductscience.org/api/diseases/v1/MONDO_0006957/drugs

API reference For AI assistants