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Disease · MONDO_0013600

Comparisons in its trials65

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Circadin vs Placebo: serious adverse events1 of 3943 of 395789NCT00397189Trial comparisons
Suvorexant vs Placebo: Number of Participants Who Reported Suicidal Ideation and/or Behavior On Study Based on Responses to the Columbia Suicide Severity Rating Scale (C-SSRS)6 of 5210 of 258779NCT01021813Trial comparisons
Esmirtazapine 4.5 mg vs Placebo: Number of Participants Who Experienced Adverse Events (AEs)253 of 34275 of 115457NCT00631657Trial comparisons
Esmirtazapine 4.5 mg vs Placebo: Number of Participants Who Discontinued Study Drug Due to an AE47 of 3427 of 115457NCT00631657Trial comparisons
Esmirtazapine 4.5 mg vs Placebo: serious adverse events8 of 3422 of 115457NCT00631657Trial comparisons
Tasimelteon vs Placebo: deaths from any cause0 of 1600 of 160320NCT03373201Trial comparisons
Tasimelteon vs Placebo: serious adverse events1 of 1600 of 160320NCT03373201Trial comparisons
Zolpidem 3.5 mg vs Placebo: serious adverse events0 of 1500 of 145295NCT00466193Trial comparisons
Suvorexant vs Placebo: deaths from any cause0 of 1420 of 143285NCT02750306Trial comparisons
Suvorexant vs Placebo: serious adverse events1 of 1420 of 143285NCT02750306Trial comparisons
Esmirtazapine 1.5 mg vs Esmirtazapine 3.0 mg: Number of Participants Who Discontinue Study Drug Due to an AE21 of 12824 of 131259NCT00561574Trial comparisons
Esmirtazapine 1.5 mg vs Esmirtazapine 3.0 mg: Number of Participants Who Experience at Least One Adverse Event (AE)115 of 128116 of 131259NCT00561574Trial comparisons
Esmirtazapine 1.5 mg vs Esmirtazapine 3.0 mg: serious adverse events9 of 1286 of 131259NCT00561574Trial comparisons
Ramelteon 4 mg QD vs Placebo QD: serious adverse events0 of 1300 of 129259NCT00756002Trial comparisons
Eye Mask and Ear Plugs vs Control: Use of Zopiclone (Night Sedation)3 of 1092 of 97206NCT02732912Trial comparisons
Eye Mask and Ear Plugs vs Control: Number of Falls0 of 1090 of 97206NCT02732912Trial comparisons
Eye Mask and Ear Plugs vs Control: deaths from any cause0 of 1090 of 97206NCT02732912Trial comparisons
Eye Mask and Ear Plugs vs Control: serious adverse events0 of 1090 of 97206NCT02732912Trial comparisons
Defined CBD vs Placebo: deaths from any cause0 of 990 of 88187NCT05233761Trial comparisons
Defined CBD vs Placebo: serious adverse events0 of 990 of 88187NCT05233761Trial comparisons

diseases-2026-09-18-0.1.0

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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