Disease · MONDO_0015254

schistosomiasis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. schistosomiasis. Diseases, record MONDO_0015254. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0015254

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: schistosomiasis; Open Targets
Open Targets ID: MONDO_0015254; Open Targets
Other names: Bilharzia, Katayama Fever, bilharziasis, snail fever; Open Targets
Disease Ontology: DOID:1395; Disease Ontology
MeSH: D012552; MeSH
NCI Thesaurus: C35000; NCI Thesaurus
Orphanet: ORPHA:1247; Orphanet
Highest stage of its drugs: Approval, for 2 of its 18 drugs, from DailyMed and TTD; Open Targets

Drugs18

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
PRAZIQUANTEL	CHEMBL976	Small molecule	Approval	DailyMed	17	16	16	Drugs and targets
OXAMNIQUINE	CHEMBL847	Small molecule	Approval	TTD	1	0	0	Drugs and targets
ARTESUNATE	CHEMBL361497	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
PYRIMETHAMINE	CHEMBL36	Small molecule	Phase 3	ClinicalTrials.gov	2	2	1	Drugs and targets
MEFLOQUINE	CHEMBL416956	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
SULFALENE	CHEMBL1525826	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ALBENDAZOLE	CHEMBL1483	Small molecule	Unknown	ClinicalTrials.gov	4	4	4	Drugs and targets
FERROUS SULFATE	CHEMBL1200830	Small molecule	Unknown	ClinicalTrials.gov	2	2	1	Drugs and targets
AMODIAQUINE	CHEMBL682	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
ARTEMETHER	CHEMBL566534	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 18

See all 18 drugs

Targets0

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

None in this release.

Trials20

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02806232	An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni)	Phase 2	444	2019-11-20	Schistosomiasis	PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT03845140	L-PZQ ODT in Schistosoma Infected Children	Phase 3	288	2024-03-21	Schistosomiasis	PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT02162875	Schistosoma Mansoni in Mwanza Region, Tanzania	Not applicable	37,500		Schistosoma Mansoni	PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT01541631	A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes	Not applicable	2,000		Anemia, Intestinal Helminthiasis, Intestinal Schistosomiasis, Human Immunodeficiency Virus I Infection, Hematologic Diseases, Opportunistic Infections	ALBENDAZOLE, PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT00414479	Assessment of Anaemia Attributable to Schistosomiasis in School Children in Kenya: Mechanisms and Effect of Treatment		1,500		Anaemia, Schistosomiasis Infection, Malaria, Iron Deficiency	ARTEMETHER, PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT01901484	Schistosoma Mansoni Morbidity in Children Aged 1-5 Years	Phase 2	800		Intestinal Schistosomiasis	PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT03893097	Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children	Phase 3	726		Schistosoma Haematobium, Schistosoma Mansoni	ARTESUNATE, MEFLOQUINE	Its record names the disease	ClinicalTrials.gov
NCT01050374	Safety and Efficacy of Drug Combinations Against Schistosomiasis	Not applicable	650		Parasitic Diseases	ALBENDAZOLE, MEBENDAZOLE, PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT05354258	Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children	Not applicable	600		Malaria, Soil Transmitted Helminths, Schistosomiasis, Integrated Control, Seasonal Malaria Chemoprevention, Mass Drug Administration With Anthelminthic Drugs	ALBENDAZOLE, AMODIAQUINE, PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT00215267	The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and re-Infection Along Lake Victoria, Uganda	Not applicable	540		Schistosomiasis, Malaria	PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov

1 to 10 of 20

See all 20 trials

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Cohort 1a: 4 to 6 Years L-PZQ ODT 50 mg/kg vs Cohort 1b: 4 to 6 Years Biltricide® 40 mg/kg: Cohort 1a and Cohort 1b: Number of Participants With Clinical Cure Determined by Kato-Katz Method	86 of 98	39 of 48	146	NCT03845140	Trial comparisons
Cohort 2: 2 to 3 Years L-PZQ ODT 50 mg/kg vs Cohort 3: 3 to 24 Months L-PZQ ODT 50 mg/kg: Cohort 2 and Cohort 3: Number of Participants With Clinical Cure Determined by Kato-Katz Method	27 of 29	17 of 18	47	NCT03845140	Trial comparisons

Papers from its trials15

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
40412398	RESULT	1	PubMed
32196506	RESULT	1	PubMed
38177851	DERIVED	1	PubMed
37957702	DERIVED	1	PubMed
37722662	DERIVED	1	PubMed
36893784	DERIVED	1	PubMed
36581796	DERIVED	1	PubMed
36548444	DERIVED	1	PubMed
35922819	DERIVED	1	PubMed
34168029	DERIVED	1	PubMed

1 to 10 of 15

See all 15 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0015254

GET https://conductscience.org/api/diseases/v1/MONDO_0015254/drugs

API reference For AI assistants