Disease · MONDO_0100159
Trials12
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
1 to 12 of 12
Download this page as JSON| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01720524 | A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn | Phase 3 | 59 | 2020-03-25 | Pulmonary Hypertension, Familial Persistent, of the Newborn | SILDENAFIL | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT06603766 | Treatment of Persistent Pulmonary Hypertension in Neonates With Nebulized Magnesium Sulfate | Phase 2/3 | 40 | 2025-02-05 | Magnesium Sulfate - PPHN | MAGNESIUM SULFATE | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT01088997 | Pharmacokinetic Study of Milrinone in Babies With Persistent Pulmonary Hypertension of the Newborn | Not applicable | 12 | 2016-07-12 | Persistent Fetal Circulation Syndrome | MILRINONE | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT01069861 | Study To Investigate Safety And Efficacy Of Sildenafil In The Newborns With Persistent Pulmonary Hypertension (PPHN) | Phase 2 | 4 | 2012-12-03 | PPHN, Persistent Pulmonary Hypertension of the Newborn, Hypoxic Respiratory Failure | SILDENAFIL | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT05527704 | the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial) | Phase 3 | 608 | TTN, Respiratory Failure, PPHN | ALBUTEROL | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT00139217 | NO Need to Ventilate: A Trial of Non-invasive Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn | Not applicable | 400 | Pulmonary Hypertension | NITRIC OXIDE | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT05741229 | The Effect Of Nebulizied Nitroglycerin As An Adjuvant Therapy For Persistent Pulmonary Hypertension Of Newborns | Not applicable | 80 | Persistent Pulmonary Hypertension of the Newborn, Echocardiography, Respiratory Disease | NITROGLYCERIN | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT07090720 | Melatonin Effects on the Left Ventricular Function in Neonates With Persistent Pulmonary Hypertension | Not applicable | 80 | Melatonin, Left Ventricular Function, Neonates, Persistent Pulmonary Hypertension | MELATONIN | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT04031508 | Effect of a Parenteral Emulsion With Omega3 on Neonates With PPHN and CDH | Phase 2 | 40 | Pulmonary Hypertension of Newborn, Diaphragm Defect | OMEGA-3 FATTY ACIDS | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT04328636 | Nebulized MgSO4 in Persistent Pulmonary Hypertension of Newborn | Phase 1/2 | 28 | Persistent Fetal Circulation, Persistent Pulmonary Hypertension of the Newborn, PPHN | MAGNESIUM SULFATE | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT00598429 | Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure | Phase 2 | 0 | Infant, Newborn, Respiratory Insufficiency, Pulmonary Hypertension, Respiratory Distress Syndrome, Newborn, Streptococcal Infections | ALPROSTADIL | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT04912726 | Endovenous Sildenafil Early Management in Newborns Pulmonary Hypertension | Not applicable | 0 | Hypertension, Pulmonary | SILDENAFIL | Open Targets' reading of its record | ClinicalTrials.gov |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0100159/trials