Gene · 10019
SH2B3: SH2B adaptor protein 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SH2B3: SH2B adaptor protein 3. Genes, record 10019. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10019
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UQQ2 | SH2B adapter protein 3 | 575 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63343 | Q9UQQ2 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1023 | Q9UQQ2 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6845 | Q9UQQ2 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5202 | Q9UQQ2 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1023 | Q9UQQ2 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6845 | Q9UQQ2 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5202 | Q9UQQ2 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 734 | Q9UQQ2 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 78530 | Q9UQQ2 | Espacenet |
| US 11432537 B2 | 2022-09-06 | 2 | Q9UQQ2 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,324
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SH2B3 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 29 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 16 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 16 | 2025 |
| ZIAHL006001 | Framingham Project/Levy | 16 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 14 | 2025 |
| P01CA108671 | Myeloproliferative Neoplasms-Research Consortium | 11 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 9 | 2025 |
| ZIAHL006170 | Cardiovascular Genomics and Bioinformatics projects | 9 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 8 | 2025 |
1 to 10 of 2,324Source NIH's project files
See all 2,324 nih grantsPapers2,160
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SH2B3 Promotes PD-L1-Mediated Immune Evasion in Glioblastoma via BRCC3-Dependent IGF2BP2 Stabilization. | Int J Biol Sci | 2026 | 42807322 | PubTator, text mining | PubMed |
| LNK expression, subcellular localisation and survival associations in breast, cervical and colorectal cancer. | Biomol Biomed | 2026 | 42751986 | PubTator, text mining | PubMed |
| The bioinformatics approach to identifying pathogenic variants for colorectal cancer (CRC). | J Genet Eng Biotechnol | 2026 | 42749394 | PubTator, text mining | PubMed |
| The Germline SH2B3rs111340708 Splicing Variant Drives Intron Retention and Protein Instability by Impacting Clinical Outcomes in Core Binding Factor AML. | Hematol Oncol | 2026 | 42731102 | PubTator, text mining | PubMed |
| Age as a core disease modifier: Distinct clinical, molecular and prognostic landscapes of essential thrombocythaemia in adolescents and young adults. | Br J Haematol | 2026 | 42698068 | PubTator, text mining | PubMed |
| Beyond triple-negative: germline MPL and SH2B3/LNK mutations reshape the genetic landscape of hereditary thrombocytosis. | Haematologica | 2026 | 42622095 | PubTator, text mining | PubMed |
| Post-Treatment Persistent Erythrocytosis in Patients with Hodgkin Lymphoma: Molecular Mechanisms Underlying the Pathogenesis of Erythrocytosis. | Cancers (Basel) | 2026 | 42588719 | PubTator, text mining | PubMed |
| LNK1/2 mediate circadian-gated thermotolerance by regulating ROS homeostasis and activating HSFA8-dependent feedback to maintain temperature compensation. | Plant Commun | 2026 | 42522196 | PubTator, text mining | PubMed |
| The masquerade of motives: the immunophenotypic ambiguity in acute leukemias of ambiguous lineage, not otherwise specified. | Lab Med | 2026 | 42492073 | PubTator, text mining | PubMed |
| Genome-wide cross-trait analysis reveals immunogenetic pleiotropy between autoimmune diseases and myocardial infarction and prioritizes therapeutic targets. | Atherosclerosis | 2026 | 42462659 | PubTator, text mining | PubMed |
1 to 10 of 2,160
See all 2,160 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10019
GET https://conductscience.org/api/genes/v1/10019/patents?page=2