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Gene · 10019

SH2B3: SH2B adaptor protein 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SH2B3: SH2B adaptor protein 3. Genes, record 10019. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10019

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Gene

Symbol
SH2B3
HGNC
Name
SH2B adaptor protein 3
HGNC
NCBI Gene ID
10019
NCBI Gene
HGNC ID
HGNC:29605
HGNC
Ensembl
ENSG00000111252
NCBI Gene
Aliases
IDDM20, LNK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UQQ2SH2B adapter protein 35750Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463343Q9UQQ2Espacenet
EP 4640849 A22025-10-291023Q9UQQ2Espacenet
EP 4641201 A22025-10-296845Q9UQQ2Espacenet
EP 4641202 A22025-10-295202Q9UQQ2Espacenet
JP 2025519096 A2025-06-241023Q9UQQ2Espacenet
JP 2025517969 A2025-06-126845Q9UQQ2Espacenet
KR 1020250017231 A2025-02-045202Q9UQQ2Espacenet
US 11884978 B22024-01-30734Q9UQQ2Espacenet
US 11446398 B22022-09-2078530Q9UQQ2Espacenet
US 11432537 B22022-09-062Q9UQQ2Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,324

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSH2B3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant292025
P30CA008748Cancer Center Support Grant192025
P30CA021765Cancer Center Support Grant (CCSG)162025
P30DK063491Diabetes Research Center (DRC)162025
ZIAHL006001Framingham Project/Levy162025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal142025
P01CA108671Myeloproliferative Neoplasms-Research Consortium112025
P30CA076292Moffitt Cancer Center Support Grant92025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects92025
P30CA068485Cancer Center Support Grant82025

1 to 10 of 2,324Source NIH's project files

See all 2,324 nih grants

Papers2,160

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SH2B3 Promotes PD-L1-Mediated Immune Evasion in Glioblastoma via BRCC3-Dependent IGF2BP2 Stabilization.Int J Biol Sci202642807322PubTator, text miningPubMed
LNK expression, subcellular localisation and survival associations in breast, cervical and colorectal cancer.Biomol Biomed202642751986PubTator, text miningPubMed
The bioinformatics approach to identifying pathogenic variants for colorectal cancer (CRC).J Genet Eng Biotechnol202642749394PubTator, text miningPubMed
The Germline SH2B3rs111340708 Splicing Variant Drives Intron Retention and Protein Instability by Impacting Clinical Outcomes in Core Binding Factor AML.Hematol Oncol202642731102PubTator, text miningPubMed
Age as a core disease modifier: Distinct clinical, molecular and prognostic landscapes of essential thrombocythaemia in adolescents and young adults.Br J Haematol202642698068PubTator, text miningPubMed
Beyond triple-negative: germline MPL and SH2B3/LNK mutations reshape the genetic landscape of hereditary thrombocytosis.Haematologica202642622095PubTator, text miningPubMed
Post-Treatment Persistent Erythrocytosis in Patients with Hodgkin Lymphoma: Molecular Mechanisms Underlying the Pathogenesis of Erythrocytosis.Cancers (Basel)202642588719PubTator, text miningPubMed
LNK1/2 mediate circadian-gated thermotolerance by regulating ROS homeostasis and activating HSFA8-dependent feedback to maintain temperature compensation.Plant Commun202642522196PubTator, text miningPubMed
The masquerade of motives: the immunophenotypic ambiguity in acute leukemias of ambiguous lineage, not otherwise specified.Lab Med202642492073PubTator, text miningPubMed
Genome-wide cross-trait analysis reveals immunogenetic pleiotropy between autoimmune diseases and myocardial infarction and prioritizes therapeutic targets.Atherosclerosis202642462659PubTator, text miningPubMed

1 to 10 of 2,160

See all 2,160 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10019

GET https://conductscience.org/api/genes/v1/10019/patents?page=2