Gene · 10021
HCN4: hyperpolarization activated cyclic nucleotide gated potassium channel 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HCN4: hyperpolarization activated cyclic nucleotide gated potassium channel 4. Genes, record 10021. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10021
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y3Q4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 1,203 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents39
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49578 | Q9Y3Q4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1561 | Q9Y3Q4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1923 | Q9Y3Q4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1923 | Q9Y3Q4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1561 | Q9Y3Q4 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29490 | Q9Y3Q4 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 29490 | Q9Y3Q4 | Espacenet |
| JP 2024517810 A | 2024-04-23 | 78 | Q9Y3Q4 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 29490 | Q9Y3Q4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39368 | Q9Y3Q4 | Espacenet |
1 to 10 of 39
See all 39 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| DRONEDARONE | CHEMBL184412 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker | BLOCKER | ChEMBL |
| DRONEDARONE HYDROCHLORIDE | CHEMBL1201729 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker | BLOCKER | ChEMBL |
| IVABRADINE | CHEMBL471737 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker | BLOCKER | ChEMBL |
| IVABRADINE HYDROCHLORIDE | CHEMBL2145077 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker | BLOCKER | ChEMBL |
Trials73
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07268170 | IVABRADINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06742164 | IVABRADINE | ClinicalTrials.gov | ||
| NCT06505668 | IVABRADINE | ClinicalTrials.gov | ||
| NCT06312891 | IVABRADINE | ClinicalTrials.gov | ||
| NCT06305806 | IVABRADINE | PHASE2 | ClinicalTrials.gov | |
| NCT06305780 | IVABRADINE | PHASE2 | ClinicalTrials.gov | |
| NCT06096337 | DRONEDARONE | ClinicalTrials.gov | ||
| NCT05939076 | DRONEDARONE | PHASE3 | ClinicalTrials.gov | |
| NCT05655468 | DRONEDARONE | PHASE4 | ClinicalTrials.gov | |
| NCT05594342 | IVABRADINE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 73
See all 73 trialsNIH grants1,074
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HCN4 papers | Newest fiscal year |
|---|---|---|---|
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 13 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 7 | 2025 |
| R01HL135109 | Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation | 7 | 2025 |
| T32HL007208 | Integrated, Multidisciplinary Training in Cardiovascular Research | 6 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 5 | 2025 |
| T32HL086350 | Training Program in Basic and Translational Cardiovascular Science | 5 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 4 | 2025 |
| R01GM098592 | Structural and functional studies of Hsp70/Hsp110 molecular chaperones | 4 | 2025 |
| R01HL076485 | Engineering Vascularized Cardiac Muscle | 4 | 2025 |
1 to 10 of 1,074Source NIH's project files
See all 1,074 nih grantsPapers1,759
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic loci responsible for atrioventricular block in children. | Front Cell Dev Biol | 2026 | 42798645 | PubTator, text mining | PubMed |
| The proximal N terminus of IRAG is required for potentiation of HCN4 channels. | J Gen Physiol | 2026 | 42720667 | PubTator, text mining | PubMed |
| Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species. | Exp Physiol | 2026 | 42669770 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| The HCN4 channel modulates external tufted cell burst firing. | J Neurophysiol | 2026 | 42606887 | PubTator, text mining | PubMed |
| The Hyperpolarization-Activated, Cyclic-Nucleotide (HCN) Ion Channel Inhibitors as Potential Therapy for Pain, CNS Disorders, Psychiatric Disorders, and Tinnitus. | ACS Med Chem Lett | 2026 | 42445009 | PubTator, text mining | PubMed |
| Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism. | Arch Pharm (Weinheim) | 2026 | 42424558 | PubTator, text mining | PubMed |
| Current Topics of Progressive Cardiac Conduction Disease. | J Arrhythm | 2026 | 42368294 | PubTator, text mining | PubMed |
| Rare Truncating HAND2 Variants Predispose to Atrial Fibrillation. | Genes (Basel) | 2026 | 42353861 | PubTator, text mining | PubMed |
| Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel. | Biochem Cell Biol | 2026 | 42241720 | PubTator, text mining | PubMed |
1 to 10 of 1,759
See all 1,759 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10021
GET https://conductscience.org/api/genes/v1/10021/patents?page=2