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Gene · 10021

HCN4: hyperpolarization activated cyclic nucleotide gated potassium channel 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HCN4: hyperpolarization activated cyclic nucleotide gated potassium channel 4. Genes, record 10021. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10021

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Gene

Symbol
HCN4
HGNC
Name
hyperpolarization activated cyclic nucleotide gated potassium channel 4
HGNC
NCBI Gene ID
10021
NCBI Gene
HGNC ID
HGNC:16882
HGNC
Ensembl
ENSG00000138622
NCBI Gene
Aliases
BRGDA8, EIG18, SSS2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y3Q4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 41,2038Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449578Q9Y3Q4Espacenet
EP 4641201 A22025-10-291561Q9Y3Q4Espacenet
JP 2025529142 A2025-09-041923Q9Y3Q4Espacenet
US 12371689 B22025-07-291923Q9Y3Q4Espacenet
JP 2025517969 A2025-06-121561Q9Y3Q4Espacenet
JP 2025032204 A2025-03-1129490Q9Y3Q4Espacenet
EP 4461818 A22024-11-1329490Q9Y3Q4Espacenet
JP 2024517810 A2024-04-2378Q9Y3Q4Espacenet
JP 2023058610 A2023-04-2529490Q9Y3Q4Espacenet
US 11446398 B22022-09-2039368Q9Y3Q4Espacenet

1 to 10 of 39

See all 39 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DRONEDARONECHEMBL184412Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blockerBLOCKERChEMBL
DRONEDARONE HYDROCHLORIDECHEMBL1201729Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blockerBLOCKERChEMBL
IVABRADINECHEMBL471737Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blockerBLOCKERChEMBL
IVABRADINE HYDROCHLORIDECHEMBL2145077Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blockerBLOCKERChEMBL

Trials73

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,074

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHCN4 papersNewest fiscal year
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL132025
R01HL085844Functional interactions of cardiac ion channels72025
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation72025
T32HL007208Integrated, Multidisciplinary Training in Cardiovascular Research62025
P30DK063491Diabetes Research Center (DRC)52025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling52025
T32HL086350Training Program in Basic and Translational Cardiovascular Science52025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology42025
R01GM098592Structural and functional studies of Hsp70/Hsp110 molecular chaperones42025
R01HL076485Engineering Vascularized Cardiac Muscle42025

1 to 10 of 1,074Source NIH's project files

See all 1,074 nih grants

Papers1,759

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic loci responsible for atrioventricular block in children.Front Cell Dev Biol202642798645PubTator, text miningPubMed
The proximal N terminus of IRAG is required for potentiation of HCN4 channels.J Gen Physiol202642720667PubTator, text miningPubMed
Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species.Exp Physiol202642669770PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
The HCN4 channel modulates external tufted cell burst firing.J Neurophysiol202642606887PubTator, text miningPubMed
The Hyperpolarization-Activated, Cyclic-Nucleotide (HCN) Ion Channel Inhibitors as Potential Therapy for Pain, CNS Disorders, Psychiatric Disorders, and Tinnitus.ACS Med Chem Lett202642445009PubTator, text miningPubMed
Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism.Arch Pharm (Weinheim)202642424558PubTator, text miningPubMed
Current Topics of Progressive Cardiac Conduction Disease.J Arrhythm202642368294PubTator, text miningPubMed
Rare Truncating HAND2 Variants Predispose to Atrial Fibrillation.Genes (Basel)202642353861PubTator, text miningPubMed
Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel.Biochem Cell Biol202642241720PubTator, text miningPubMed

1 to 10 of 1,759

See all 1,759 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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