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Gene · 10021

Papers1,759

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Interplay Between Ca2+ Homeostasis, Endoplasmic Reticulum Stress, and the Unfolded Protein Response in Human Diseases.Cells202641744795PubTator, text miningPubMed
Mechanisms of mitral valve development and disease.Front Cardiovasc Med202641717582PubTator, text miningPubMed
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia.J Gen Physiol202641649805PubTator, text miningPubMed
Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension-associated genes.Biomol Biomed202641564389PubTator, text miningPubMed
Spatial transcriptomics in the human left atrial appendage and pulmonary vein sleeve.Cardiovasc Pathol202641314481PubTator, text miningPubMed
Genetic testing after sudden death with negative ancillary investigations: A French prospective study with multidisciplinary collaboration.Forensic Sci Int Genet202641124747PubTator, text miningPubMed
Structure mirroring function: What's the 'matter' with the funny current?J Physiol202640013960PubTator, text miningPubMed
Sinoatrial Node Dynamics: Clinical Relevance and microRNA-Based Modulation of Pacemaker Activity.Cureus202541416334PubTator, text miningPubMed
Extracellular activation of HCN4 by a subtype-specific nanobody.Nat Commun202541326336PubTator, text miningPubMed
The "Now" and "Next" in Precision Cardiovascular Medicine.Biomedicines202541301790PubTator, text miningPubMed
HCN4 Short Truncation Mutation in a Family With 'Cardiomyopathy' Showing Severe Mitral Valve Prolapse and Sick Sinus Syndrome.Circ J202541260694PubTator, text miningPubMed
HCN4 Mutation Causing Familial Inappropriate Sinus Tachycardia Leads to a Conformational Change Mimicking cAMP Binding and Induces Constitutive Channel Activity.Circ Arrhythm Electrophysiol202541084804PubTator, text miningPubMed
Aberrant HCN4 channel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis.Br J Pharmacol202541084323PubTator, text miningPubMed
Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease.Proc Natl Acad Sci U S A202540932774PubTator, text miningPubMed
Atrioventricular Node Dysfunction in Heart Failure: New Horizons from Pathophysiology to Therapeutic Perspectives.J Cardiovasc Dev Dis202540863376PubTator, text miningPubMed
A Rationale for the Use of Ivabradine in the Perioperative Phase of Cardiac Surgery: A Review.J Cardiovasc Dev Dis202540863360PubTator, text miningPubMed
Dysregulation of the cAMP Signaling Pathway Mediated by Shared Hub Genes: Diagnostic, Prognostic, and Therapeutic Insights into Thyroid Cancer and Graves' Disease.Comb Chem High Throughput Screen202540776656PubTator, text miningPubMed
Integrative approaches in cardiac tissue engineering: Bridging cellular complexity to create accurate physiological models.iScience202540697825PubTator, text miningPubMed
miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment.Heart Rhythm202540645436PubTator, text miningPubMed
A rare HCN4 variant combined with sick sinus syndrome, left ventricular noncompaction, and complex congenital heart disease.Channels (Austin)202540613349PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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