ConductScience.org, home

Gene · 10075

HUWE1: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HUWE1: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. Genes, record 10075. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10075

On this page

Gene

Symbol
HUWE1
HGNC
Name
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
HGNC
NCBI Gene ID
10075
NCBI Gene
HGNC ID
HGNC:30892
HGNC
Ensembl
ENSG00000086758
NCBI Gene
Aliases
ARF-BP1, HECTH9, HSPC272, Ib772, KIAA0312, LASU1, MRXST, MULE, URE-B1, UREB1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q7Z6Z7E3 ubiquitin-protein ligase HUWE14,37419Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448837Q7Z6Z7Espacenet
JP 2026004568 A2026-01-1448838Q7Z6Z7Espacenet
EP 4650780 A22025-11-192128Q7Z6Z7Espacenet
EP 4641201 A22025-10-291698Q7Z6Z7Espacenet
JP 2025529142 A2025-09-042019Q7Z6Z7Espacenet
US 12371689 B22025-07-292019Q7Z6Z7Espacenet
JP 2025517969 A2025-06-121698Q7Z6Z7Espacenet
JP 2025517970 A2025-06-122128Q7Z6Z7Espacenet
JP 2025024198 A2025-02-1911853Q7Z6Z7Espacenet
JP 2024530931 A2024-08-271Q7Z6Z7Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,315

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHUWE1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant162025
P30CA008748Cancer Center Support Grant112025
P30CA023108Cancer Center Support Grant62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
P30CA022453CANCER CENTER SUPPORT GRANT52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
F30CA264513Elucidating the Role of C16orf72 in the Cellular Stress Response Network32025
P30CA016087Cancer Center Support Grant32025
P30CA033572Cancer Center Support Grant32025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant32025

1 to 10 of 1,315Source NIH's project files

See all 1,315 nih grants

Papers1,859

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Anesthetic Considerations for Dental Surgery in a Child with HUWE1-Related Neurodevelopmental Disorder, Lennox-Gastaut Syndrome, and Blindness: A Case Report.J Perianesth Nurs202642820895PubTator, text miningPubMed
LIMCH1 in Cancer: A Context-Dependent Modulator Beyond the Tumor Suppressor-Oncogene Dichotomy.Int J Mol Sci202642794574PubTator, text miningPubMed
Fluorophore placement and size impact E2 ubiquitination efficiency.Biochem J202642770861PubTator, text miningPubMed
Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins.Mol Cell202642753704PubTator, text miningPubMed
Spatial control of mitochondrial ubiquitination by the AMBRA1-RMC1-HUWE1 axis.Autophagy202642747977PubTator, text miningPubMed
A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer.Genes Dev202642722432PubTator, text miningPubMed
Clinical and genetic features of syndromic craniosynostosis in 18 Chinese probands: novel candidate genes and phenotypes of known pathogenic genes.Front Genet202642609909PubTator, text miningPubMed
Correction: PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1.Front Immunol202642582571PubTator, text miningPubMed
Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment.bioRxiv202642582009PubTator, text miningPubMed
Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function.PLoS Genet202642574471PubTator, text miningPubMed

1 to 10 of 1,859

See all 1,859 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10075

GET https://conductscience.org/api/genes/v1/10075/patents?page=2