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HUWE1: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
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Gene · 10075

Papers1,859

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 1,859

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TitleJournalYearPMIDFound bySource
Anesthetic Considerations for Dental Surgery in a Child with HUWE1-Related Neurodevelopmental Disorder, Lennox-Gastaut Syndrome, and Blindness: A Case Report.J Perianesth Nurs202642820895PubTator, text miningPubMed
LIMCH1 in Cancer: A Context-Dependent Modulator Beyond the Tumor Suppressor-Oncogene Dichotomy.Int J Mol Sci202642794574PubTator, text miningPubMed
Fluorophore placement and size impact E2 ubiquitination efficiency.Biochem J202642770861PubTator, text miningPubMed
Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins.Mol Cell202642753704PubTator, text miningPubMed
Spatial control of mitochondrial ubiquitination by the AMBRA1-RMC1-HUWE1 axis.Autophagy202642747977PubTator, text miningPubMed
A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer.Genes Dev202642722432PubTator, text miningPubMed
Clinical and genetic features of syndromic craniosynostosis in 18 Chinese probands: novel candidate genes and phenotypes of known pathogenic genes.Front Genet202642609909PubTator, text miningPubMed
Correction: PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1.Front Immunol202642582571PubTator, text miningPubMed
Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment.bioRxiv202642582009PubTator, text miningPubMed
Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function.PLoS Genet202642574471PubTator, text miningPubMed
Disruption of RBPJ in liver cancer-infiltrating T cells enhances antitumor immunity through remodeling epigenetic landscape.Cell Death Differ202642562885PubTator, text miningPubMed
Tanshinone I as a novel ferritinophagy inducer triggers ferroptosis to suppress gastric cancer growth.Phytomedicine202642542057PubTator, text miningPubMed
Identification of novel HUWE1 variants in Turner-type X-linked intellectual disability.Eur J Med Genet202642526793PubTator, text miningPubMed
G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells.Nat Commun202642399234PubTator, text miningPubMed
PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1.Front Immunol202642396433PubTator, text miningPubMed
Clinical Utility of Rapid Whole-Genome Sequencing in Hospitalized Adults With Unexplained Neurologic Presentations.Neurology202642302220PubTator, text miningPubMed
Deciphering the Ubiquitin-like Code of DNA-PK: Mechanisms and Therapeutic Opportunities.Biomolecules202642072620PubTator, text miningPubMed
35 Individuals With HUWE1-Related Neurodevelopmental Disorder and Suggested Clinical Evaluations.Am J Med Genet A202641975654PubTator, text miningPubMed
Turnover of missense mutant cytosolic proteins proceeds in the absence of major quality control E3 ligases.MicroPubl Biol202641969808PubTator, text miningPubMed
O-GlcNAc modification orchestrates HUWE1-mediated ubiquitination of TfR1 to regulate ferroptosis and trophoblast syncytialization in preeclampsia.Free Radic Biol Med202641962599PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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