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HUWE1: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
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Gene · 10075

Papers1,859

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

21 to 40 of 1,859

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TitleJournalYearPMIDFound bySource
The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer.Cell Death Dis202641942468PubTator, text miningPubMed
Molecular mechanisms of NLRP3 inflammasome activation.Exp Mol Med202641876821PubTator, text miningPubMed
Sphingosine-1-phosphate promotes CD8 T cell exhaustion in breast cancer via exosomal transfer of TGFBR2.Cell Death Dis202641872131PubTator, text miningPubMed
Lactylation stabilizes PD-L1 to promote tumor immune evasion and cell growth.Cell Death Dis202641864972PubTator, text miningPubMed
Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.EMBO J202641862643PubTator, text miningPubMed
The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets.Mol Biomed202641857315PubTator, text miningPubMed
A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.Proc Natl Acad Sci U S A202641855256PubTator, text miningPubMed
High diffuse bone marrow uptake in 18F-FDG PET/CT may reflect the diverse mutational characteristics of multiple myeloma.Korean J Intern Med202641850222PubTator, text miningPubMed
Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage.Nucleic Acids Res202641841497PubTator, text miningPubMed
Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies.Mol Syst Biol202641814068PubTator, text miningPubMed
Human cranial stem cells: developmental, pathologic, and therapeutic implications.Front Cell Dev Biol202641768990PubTator, text miningPubMed
ALDH1L2 orchestrates redox-growth coupling in renal carcinoma: pan-cancer evidence and mechanistic validation of the ROS-Akt/mTOR/S6K axis.Front Immunol202641766916PubTator, text miningPubMed
Proteasomal control of transcription factors: mechanisms, regulation and dysregulation.Cell Mol Life Sci202641764121PubTator, text miningPubMed
Targeted Protein Degradation in Cancer: PROTACs, New Targets, and Clinical Mechanisms.Biomolecules202641750393PubTator, text miningPubMed
OGG1 and MUTYH DNA Glycosylases, the Dynamic Duo Against 8-Oxoguanine DNA Lesion: Structure, Regulation, and Novel Emerging Roles.Biomolecules202641750327PubTator, text miningPubMed
Chromosome 3p Deletion Leads to Extensive Genomic Alterations in Diverse Cancers and Confers Synthetic Lethality in Uveal Melanoma.Cancers (Basel)202641749941PubTator, text miningPubMed
Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A.Cell Death Dis202641748538PubTator, text miningPubMed
Targeting Glycolytic Metabolism in Cancer Therapy: Current Approaches and Future Perspectives.Cells202641744805PubTator, text miningPubMed
Tankyrases and Their Binding Proteins: Origins of Their Roles in Diverse Cellular Pathways.Cells202641744791PubTator, text miningPubMed
Rewriting the viral script: post-translational modifications orchestrating SARS-CoV-2 pathogenesis and immune evasion.Front Microbiol202641743132PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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