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Gene · 10243

GPHN: gephyrin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GPHN: gephyrin. Genes, record 10243. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10243

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Gene

Symbol
GPHN
HGNC
Name
gephyrin
HGNC
NCBI Gene ID
10243
NCBI Gene
HGNC ID
HGNC:15465
HGNC
Ensembl
ENSG00000171723
NCBI Gene
Aliases
GEPH, GPH, GPHRYN, HKPX1, KIAA1385, MOCODC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NQX3Gephyrin7361Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21360Q9NQX3Espacenet
JP 2026004568 A2026-01-1447528Q9NQX3Espacenet
EP 4641201 A22025-10-294433Q9NQX3Espacenet
JP 2025517969 A2025-06-124433Q9NQX3Espacenet
JP 2025032204 A2025-03-1129184Q9NQX3Espacenet
EP 4461818 A22024-11-1329184Q9NQX3Espacenet
JP 2023521663 A2023-05-25359Q9NQX3Espacenet
JP 2023058610 A2023-04-2529184Q9NQX3Espacenet
US 11446398 B22022-09-2034515Q9NQX3Espacenet
JP 2022524081 A2022-04-27137486Q9NQX3Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,242

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGPHN papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
R01GM129325ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling52025
ZIANS003136The regulation of synaptic transmission and neural circuit function52025
R35NS116879Novel approaches for interrogating and manipulating synaptic function, structure and plasticity42025
P30CA008748Cancer Center Support Grant32025
R01MH126017Cellular Mechanisms of Neuroligin-4 Gene in Human Neurons32025
T32NS099042Neuroscience Training Grant32025
U24NS109113Molecularly Defined Immunoprobes for Scalable Brain Protein Mapping with Reference Datasets32025
UL1TR001863Yale Clinical and Translational Science Award32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025

1 to 10 of 1,242Source NIH's project files

See all 1,242 nih grants

Papers1,523

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Redox-dependent synaptic clustering of gephyrin.Nat Commun202642693144PubTator, text miningPubMed
WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior.Proc Natl Acad Sci U S A202642640800PubTator, text miningPubMed
Maternal immune activation induces sex-dependent metabolic, epigenetic and GABAergic trajectories in the hippocampus.Brain Behav Immun202642409184PubTator, text miningPubMed
Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy.EMBO Mol Med202642380307PubTator, text miningPubMed
Gephyrin Neurological Autoimmunity.Ann Neurol202642307210PubTator, text miningPubMed
Phylogenetic based dissection of eukaryotic Mo-insertase functionality: From mechanism to complex assembly.PLoS One202642284359PubTator, text miningPubMed
Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models.Cell Death Dis202642270579PubTator, text miningPubMed
Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease.J Pathol202642261605PubTator, text miningPubMed
Astrocyte-specific NRCAM deficiency promotes GABAergic synapse pruning to drive central sensitization in bone cancer pain.J Transl Med202642249478PubTator, text miningPubMed
Autophagic Pathway on GABARAP Involved in GABAA Receptor Trafficking.Neurochem Res202642225974PubTator, text miningPubMed

1 to 10 of 1,523

See all 1,523 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10243

GET https://conductscience.org/api/genes/v1/10243/patents?page=2