ConductScience.org, home

Gene · 10657

KHDRBS1: KH RNA binding domain containing, signal transduction associated 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. KHDRBS1: KH RNA binding domain containing, signal transduction associated 1. Genes, record 10657. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10657

On this page

Gene

Symbol
KHDRBS1
HGNC
Name
KH RNA binding domain containing, signal transduction associated 1
HGNC
NCBI Gene ID
10657
NCBI Gene
HGNC ID
HGNC:18116
HGNC
Ensembl
ENSG00000121774
NCBI Gene
Aliases
FLJ34027, Sam68, p62, p68
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07666KH domain-containing, RNA-binding, signal transduction-associated protein 144310Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194923Q07666Espacenet
JP 2025517970 A2025-06-124923Q07666Espacenet
US 12023371 B22024-07-024653Q07666Espacenet
US 11446398 B22022-09-2043264Q07666Espacenet
JP 2022524081 A2022-04-27146235Q07666Espacenet
US 10925935 B22021-02-234653Q07666Espacenet
JP 2019033757 A2019-03-0723405Q07666Espacenet
US 10155029 B22018-12-184653Q07666Espacenet
JP 2018164458 A2018-10-255423Q07666Espacenet
JP 2017140048 A2017-08-175423Q07666Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,208

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKHDRBS1 papersNewest fiscal year
R01HD036071Genotype-Phenotype Relationships in Fragile X Families192025
P30CA016672Cancer Center Support Grant82025
T32CA009110Training in Areas Fundamental to Cancer Research72025
P01CA013106Targeting Transcription and Splicing in Cancer42025
P30CA010815Consolidated Basic Cancer Research Program42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
R01NS099280Hexanucleotide repeat translation in ALS and Frontotemporal Dementia42025
T32CA009138Molecular, Genetic and Cellular Targets of Cancer Training Program42025
ZIADK057602The consequences of the unusual mutation responsible for the Repeat Expansion Diseases42025
P30CA008748Cancer Center Support Grant32025

1 to 10 of 1,208Source NIH's project files

See all 1,208 nih grants

Papers1,948

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CircLAMA5 traps Sam68 in the cytoplasm to regulate alternative splicing and drive sunitinib resistance in ccRCC.Oncogene202642744974PubTator, text miningPubMed
RAD51AP1-MYC-Sam68 positive transcriptional feedback loop maintains lung cancer stemness.iScience202642729436PubTator, text miningPubMed
MicroRNA-345-3p expression inhibits colorectal cancer liver metastasis by targeting KHDRBS1 and TGF-β signaling pathway.Hereditas202642723084PubTator, text miningPubMed
Sam68 stimulates polymerase theta-mediated end-joining by suppressing poison exon inclusion in Polq mRNA.Nucleic Acids Res202642578367PubTator, text miningPubMed
Multi-layer network biology combined with single-cell evidence reveals core regulatory nodes in atherosclerotic plaques and potential drug-targeting directions.Naunyn Schmiedebergs Arch Pharmacol202642410224PubTator, text miningPubMed
A comprehensive long RNA landscape of multi-regional porcine lung-derived small extracellular vesicles.BMC Genomics202642393508PubTator, text miningPubMed
Retraction notice to 'Sam68 impedes the recovery of arterial injury by augmenting inflammatory response' [Journal of Molecular and Cellular Cardiology 137 (2019) 82-92].J Mol Cell Cardiol202642303533PubTator, text miningPubMed
SAM68 is a multifunctional post-transcriptional regulator of cardiomyocyte differentiation.Nucleic Acids Res202642240622PubTator, text miningPubMed
ENOX2 and the related mechanisms as potential genetic targets for varicose veins of lower extremities: An integrated bioinformatics and Mendelian analysis.Medicine (Baltimore)202642216315PubTator, text miningPubMed
Beyond SMN1 mutation: environmental predispositions and epigenetic contributors to phenotypic variability and disease severity in spinal muscular atrophy.Neuroscience202642105903PubTator, text miningPubMed

1 to 10 of 1,948

See all 1,948 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10657

GET https://conductscience.org/api/genes/v1/10657/patents?page=2