Gene · 10657
KHDRBS1: KH RNA binding domain containing, signal transduction associated 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KHDRBS1: KH RNA binding domain containing, signal transduction associated 1. Genes, record 10657. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10657
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q07666 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | 443 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 4923 | Q07666 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4923 | Q07666 | Espacenet |
| US 12023371 B2 | 2024-07-02 | 4653 | Q07666 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43264 | Q07666 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 146235 | Q07666 | Espacenet |
| US 10925935 B2 | 2021-02-23 | 4653 | Q07666 | Espacenet |
| JP 2019033757 A | 2019-03-07 | 23405 | Q07666 | Espacenet |
| US 10155029 B2 | 2018-12-18 | 4653 | Q07666 | Espacenet |
| JP 2018164458 A | 2018-10-25 | 5423 | Q07666 | Espacenet |
| JP 2017140048 A | 2017-08-17 | 5423 | Q07666 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,208
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KHDRBS1 papers | Newest fiscal year |
|---|---|---|---|
| R01HD036071 | Genotype-Phenotype Relationships in Fragile X Families | 19 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| T32CA009110 | Training in Areas Fundamental to Cancer Research | 7 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 4 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 4 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 4 | 2025 |
| R01NS099280 | Hexanucleotide repeat translation in ALS and Frontotemporal Dementia | 4 | 2025 |
| T32CA009138 | Molecular, Genetic and Cellular Targets of Cancer Training Program | 4 | 2025 |
| ZIADK057602 | The consequences of the unusual mutation responsible for the Repeat Expansion Diseases | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,208Source NIH's project files
See all 1,208 nih grantsPapers1,948
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CircLAMA5 traps Sam68 in the cytoplasm to regulate alternative splicing and drive sunitinib resistance in ccRCC. | Oncogene | 2026 | 42744974 | PubTator, text mining | PubMed |
| RAD51AP1-MYC-Sam68 positive transcriptional feedback loop maintains lung cancer stemness. | iScience | 2026 | 42729436 | PubTator, text mining | PubMed |
| MicroRNA-345-3p expression inhibits colorectal cancer liver metastasis by targeting KHDRBS1 and TGF-β signaling pathway. | Hereditas | 2026 | 42723084 | PubTator, text mining | PubMed |
| Sam68 stimulates polymerase theta-mediated end-joining by suppressing poison exon inclusion in Polq mRNA. | Nucleic Acids Res | 2026 | 42578367 | PubTator, text mining | PubMed |
| Multi-layer network biology combined with single-cell evidence reveals core regulatory nodes in atherosclerotic plaques and potential drug-targeting directions. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42410224 | PubTator, text mining | PubMed |
| A comprehensive long RNA landscape of multi-regional porcine lung-derived small extracellular vesicles. | BMC Genomics | 2026 | 42393508 | PubTator, text mining | PubMed |
| Retraction notice to 'Sam68 impedes the recovery of arterial injury by augmenting inflammatory response' [Journal of Molecular and Cellular Cardiology 137 (2019) 82-92]. | J Mol Cell Cardiol | 2026 | 42303533 | PubTator, text mining | PubMed |
| SAM68 is a multifunctional post-transcriptional regulator of cardiomyocyte differentiation. | Nucleic Acids Res | 2026 | 42240622 | PubTator, text mining | PubMed |
| ENOX2 and the related mechanisms as potential genetic targets for varicose veins of lower extremities: An integrated bioinformatics and Mendelian analysis. | Medicine (Baltimore) | 2026 | 42216315 | PubTator, text mining | PubMed |
| Beyond SMN1 mutation: environmental predispositions and epigenetic contributors to phenotypic variability and disease severity in spinal muscular atrophy. | Neuroscience | 2026 | 42105903 | PubTator, text mining | PubMed |
1 to 10 of 1,948
See all 1,948 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10657
GET https://conductscience.org/api/genes/v1/10657/patents?page=2