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Gene · 10758

TRAF3IP2: TRAF3 interacting protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRAF3IP2: TRAF3 interacting protein 2. Genes, record 10758. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10758

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Gene

Symbol
TRAF3IP2
HGNC
Name
TRAF3 interacting protein 2
HGNC
NCBI Gene ID
10758
NCBI Gene
HGNC ID
HGNC:1343
HGNC
Ensembl
ENSG00000056972
NCBI Gene
Aliases
ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, DKFZP586G0522, PSORS13
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43734E3 ubiquitin ligase TRAF3IP25741Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467278O43734Espacenet
EP 4650780 A22025-11-197021O43734Espacenet
EP 4640849 A22025-10-291029O43734Espacenet
EP 4641201 A22025-10-296904O43734Espacenet
JP 2025519096 A2025-06-241029O43734Espacenet
JP 2025517969 A2025-06-126904O43734Espacenet
JP 2025517970 A2025-06-127021O43734Espacenet
US 11446398 B22022-09-2089390O43734Espacenet
US 11446398 B22022-09-2089394O43734Espacenet
JP 2022524081 A2022-04-27192361O43734Espacenet

1 to 10 of 19

See all 19 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
IGURATIMODCHEMBL2107455E3 ubiquitin ligase TRAF3IP2 inhibitorINHIBITOR

Source ChEMBL

Trials21

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07115641IGURATIMODClinicalTrials.gov
NCT07057778IGURATIMODPHASE2ClinicalTrials.gov
NCT06945666IGURATIMODPHASE4ClinicalTrials.gov
NCT06244628IGURATIMODPHASE3ClinicalTrials.gov
NCT06146972IGURATIMODPHASE4ClinicalTrials.gov
NCT05803135IGURATIMODPHASE4ClinicalTrials.gov
NCT05789030IGURATIMODClinicalTrials.gov
NCT05302024IGURATIMODPHASE2ClinicalTrials.gov
NCT05281068IGURATIMODPHASE2ClinicalTrials.gov
NCT05216757IGURATIMODPHASE2/PHASE3ClinicalTrials.gov

1 to 10 of 21

See all 21 trials

NIH grants1,521

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRAF3IP2 papersNewest fiscal year
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis172025
R37DE022550Host and Fungal Regulation of Type 17 Immunity to Oral Candidiasis162025
P40OD010440Caenorhabditis Genetics Center152025
T32AI089474Immunology Training Program-Predoctoral112025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success102025
IK6BX004016BLRD Research Career Scientist Award Application92025
ZIAAI000887Role of HIV Envelope Proteins In Viral Replication and HIV Pathogenesis82025
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
ZIAAI001175Immunopathogenesis of Fungal Infections62025

1 to 10 of 1,521Source NIH's project files

See all 1,521 nih grants

Papers1,982

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TRAF3IP2 (Act1/CIKS) variants: A domain to phenotype framework and therapeutic implications.Cytokine Growth Factor Rev202642632295PubTator, text miningPubMed
TRAF3IP2 (rs13190932) polymorphism in psoriasis and psoriatic arthritis: susceptibility, systemic inflammation and response to methotrexate.Postepy Dermatol Alergol202642621284PubTator, text miningPubMed
Transcriptomic identification of IL-17/FOS-associated signaling in dartos fascia remodeling of pediatric concealed penis.Front Pediatr202642499569PubTator, text miningPubMed
Application of acute myocardial infarction-related key genes in noninvasive diagnosis: a comprehensive analysis based on transcriptome and single-cell transcriptome.Front Genet202642460150PubTator, text miningPubMed
LAK to CIK continuum in glioma immunotherapy: a systematic review of efficacy and safety outcomes.J Transl Med202642332740PubTator, text miningPubMed
Dual role of IL-17A in COPD: amplifier of inflammatory cascades and mediator of airway remodeling and alveolar destruction.Front Immunol202642292489PubTator, text miningPubMed
Kunxian Capsule Exerts Antitumor Effects by Activating the IL-17 Signaling Pathway to Inhibit the Proliferation, Apoptosis, Cell Cycle, and Induce Reactive Oxygen Species Production in C8166 Tumor Cells.
Curr Pharm Des202642283170PubTator, text miningPubMed
Andrographolide alleviates nasal mucosal inflammation in allergic rhinitis mice by inhibiting the IL-17/NF-κB pathway and downregulating MUC5AC expression.J Ethnopharmacol202642167662PubTator, text miningPubMed
Validating the classics: Accurate reference gene panel for reliable RT-qPCR in Porifera.PLoS One202642160319PubTator, text miningPubMed
Connexin 43 subcellular localization: From trafficking dynamics to pathophysiological outcomes and therapeutic opportunities.Cell Signal202642069098PubTator, text miningPubMed

1 to 10 of 1,982

See all 1,982 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10758

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