Gene · 10758
TRAF3IP2: TRAF3 interacting protein 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRAF3IP2: TRAF3 interacting protein 2. Genes, record 10758. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10758
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43734 | E3 ubiquitin ligase TRAF3IP2 | 574 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67278 | O43734 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7021 | O43734 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1029 | O43734 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6904 | O43734 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1029 | O43734 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6904 | O43734 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7021 | O43734 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89390 | O43734 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89394 | O43734 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 192361 | O43734 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| IGURATIMOD | CHEMBL2107455 | E3 ubiquitin ligase TRAF3IP2 inhibitor | INHIBITOR |
Source ChEMBL
Trials21
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07115641 | IGURATIMOD | ClinicalTrials.gov | ||
| NCT07057778 | IGURATIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT06945666 | IGURATIMOD | PHASE4 | ClinicalTrials.gov | |
| NCT06244628 | IGURATIMOD | PHASE3 | ClinicalTrials.gov | |
| NCT06146972 | IGURATIMOD | PHASE4 | ClinicalTrials.gov | |
| NCT05803135 | IGURATIMOD | PHASE4 | ClinicalTrials.gov | |
| NCT05789030 | IGURATIMOD | ClinicalTrials.gov | ||
| NCT05302024 | IGURATIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT05281068 | IGURATIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT05216757 | IGURATIMOD | PHASE2/PHASE3 | ClinicalTrials.gov |
1 to 10 of 21
See all 21 trialsNIH grants1,521
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRAF3IP2 papers | Newest fiscal year |
|---|---|---|---|
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 17 | 2025 |
| R37DE022550 | Host and Fungal Regulation of Type 17 Immunity to Oral Candidiasis | 16 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 15 | 2025 |
| T32AI089474 | Immunology Training Program-Predoctoral | 11 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 10 | 2025 |
| IK6BX004016 | BLRD Research Career Scientist Award Application | 9 | 2025 |
| ZIAAI000887 | Role of HIV Envelope Proteins In Viral Replication and HIV Pathogenesis | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| ZIAAI001175 | Immunopathogenesis of Fungal Infections | 6 | 2025 |
1 to 10 of 1,521Source NIH's project files
See all 1,521 nih grantsPapers1,982
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| TRAF3IP2 (Act1/CIKS) variants: A domain to phenotype framework and therapeutic implications. | Cytokine Growth Factor Rev | 2026 | 42632295 | PubTator, text mining | PubMed |
| TRAF3IP2 (rs13190932) polymorphism in psoriasis and psoriatic arthritis: susceptibility, systemic inflammation and response to methotrexate. | Postepy Dermatol Alergol | 2026 | 42621284 | PubTator, text mining | PubMed |
| Transcriptomic identification of IL-17/FOS-associated signaling in dartos fascia remodeling of pediatric concealed penis. | Front Pediatr | 2026 | 42499569 | PubTator, text mining | PubMed |
| Application of acute myocardial infarction-related key genes in noninvasive diagnosis: a comprehensive analysis based on transcriptome and single-cell transcriptome. | Front Genet | 2026 | 42460150 | PubTator, text mining | PubMed |
| LAK to CIK continuum in glioma immunotherapy: a systematic review of efficacy and safety outcomes. | J Transl Med | 2026 | 42332740 | PubTator, text mining | PubMed |
| Dual role of IL-17A in COPD: amplifier of inflammatory cascades and mediator of airway remodeling and alveolar destruction. | Front Immunol | 2026 | 42292489 | PubTator, text mining | PubMed |
Kunxian Capsule Exerts Antitumor Effects by Activating the IL-17 Signaling Pathway to Inhibit the Proliferation, Apoptosis, Cell Cycle, and Induce Reactive Oxygen Species Production in C8166 Tumor Cells. | Curr Pharm Des | 2026 | 42283170 | PubTator, text mining | PubMed |
| Andrographolide alleviates nasal mucosal inflammation in allergic rhinitis mice by inhibiting the IL-17/NF-κB pathway and downregulating MUC5AC expression. | J Ethnopharmacol | 2026 | 42167662 | PubTator, text mining | PubMed |
| Validating the classics: Accurate reference gene panel for reliable RT-qPCR in Porifera. | PLoS One | 2026 | 42160319 | PubTator, text mining | PubMed |
| Connexin 43 subcellular localization: From trafficking dynamics to pathophysiological outcomes and therapeutic opportunities. | Cell Signal | 2026 | 42069098 | PubTator, text mining | PubMed |
1 to 10 of 1,982
See all 1,982 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
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GET https://conductscience.org/api/genes/v1/10758/patents