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Gene · 10846

PDE10A: phosphodiesterase 10A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE10A: phosphodiesterase 10A. Genes, record 10846. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10846

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Gene

Symbol
PDE10A
HGNC
Name
phosphodiesterase 10A
HGNC
NCBI Gene ID
10846
NCBI Gene
HGNC ID
HGNC:8772
HGNC
Ensembl
ENSG00000112541
NCBI Gene
Aliases
ADSD2, HSPDE10A, IOLOD, PDE10A19
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y233cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A1,055359Ensembl, GeneID, HGNC

Source UniProt

Patents4

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1915990Q9Y233Espacenet
EP 4641201 A22025-10-2919333Q9Y233Espacenet
JP 2025517969 A2025-06-1219333Q9Y233Espacenet
JP 2025517970 A2025-06-1215990Q9Y233Espacenet

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BALIPODECTCHEMBL3989972Phosphodiesterase 10A inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
IBUDILASTCHEMBL19449Phosphodiesterase 10A inhibitorINHIBITORChEMBL
MARDEPODECTCHEMBL562318Phosphodiesterase 10A inhibitorINHIBITORChEMBL
PBF-999CHEMBL3942498Phosphodiesterase 10A inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials162

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 162

See all 162 trials

NIH grants676

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE10A papersNewest fiscal year
R01NS126227Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep Phenotyping82025
P51OD011132Emory National Primate Research Center52025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
R01NS103988PET Sphingosine-1-Phosphate Receptor 1 (S1P1) radiotracer for inflammation response in multiple sclerosis32025
UL1TR001863Yale Clinical and Translational Science Award32025
P30CA043703Case Comprehensive Cancer Center Support Grant22025
P30CA091842Cancer Center Support Grant22025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)22025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)22025

1 to 10 of 676Source NIH's project files

See all 676 nih grants

Papers1,053

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution.J Endocr Soc202642761548PubTator, text miningPubMed
Adaptations to breath-hold diving: from traditional divers to elite athletes.Diving Hyperb Med202642743578PubTator, text miningPubMed
Paraneoplastic neurological syndromes: an update on incidence, antibody discovery, and testing.Curr Opin Oncol202642710022PubTator, text miningPubMed
Developing a Phosphodiesterase 10A Inhibitor as a Novel Therapeutic Agent for Triple-Negative Breast Cancer.Cells202642587783PubTator, text miningPubMed
PDE10A Inhibition in Schizophrenia: A Randomised, Placebo-Controlled Phase 2 Study of Alofropodect (CPL'36) in Patients Experiencing Acute Schizophrenia.CNS Drugs202642533223PubTator, text miningPubMed
Identification of PDE10A binding ligands as potential therapeutics for the Parkinson's disease through a computational approach.Sci Rep202642426040PubTator, text miningPubMed
Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification.J Am Soc Nephrol202642308131PubTator, text miningPubMed
No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View.Neurol Int202641893061PubTator, text miningPubMed
Association of maternal smoking during pregnancy with youth depression and subsequent adult chronic diseases in offspring.Transl Psychiatry202641888109PubTator, text miningPubMed
CAMK1D as a potential therapeutic target for gut microbiota-driven promotion of lung adenocarcinoma development.PeerJ202641868793PubTator, text miningPubMed

1 to 10 of 1,053

See all 1,053 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10846

GET https://conductscience.org/api/genes/v1/10846/trials?page=2