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Gene · 11040

PIM2: Pim-2 proto-oncogene, serine/threonine kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIM2: Pim-2 proto-oncogene, serine/threonine kinase. Genes, record 11040. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11040

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Gene

Symbol
PIM2
HGNC
Name
Pim-2 proto-oncogene, serine/threonine kinase
HGNC
NCBI Gene ID
11040
NCBI Gene
HGNC ID
HGNC:8987
HGNC
Ensembl
ENSG00000102096
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9P1W9Serine/threonine-protein kinase pim-23112Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458074Q9P1W9Espacenet
JP 2025529142 A2025-09-043493Q9P1W9Espacenet
US 12371689 B22025-07-293493Q9P1W9Espacenet
US 11860162 B22024-01-021104Q9P1W9Espacenet
US 11446398 B22022-09-2063774Q9P1W9Espacenet
JP 2022524081 A2022-04-27166745Q9P1W9Espacenet
US 11078247 B22021-08-038491Q9P1W9Espacenet
US 10746735 B22020-08-181104Q9P1W9Espacenet
JP 2019054813 A2019-04-11238509Q9P1W9Espacenet
JP 2017121241 A2017-07-13238509Q9P1W9Espacenet

1 to 10 of 23

See all 23 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-1208CHEMBL3545423Serine/threonine-protein kinase PIM inhibitorINHIBITORChEMBL
LGH-447CHEMBL3651966Serine/threonine-protein kinase PIM inhibitorINHIBITORChEMBL
SGI-1776CHEMBL1952329Serine/threonine-protein kinase PIM inhibitorINHIBITORChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants911

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIM2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant72025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT62025
T32CA229102Surgical Oncology Research Training Program62025
P30CA086862Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
K12HD047349Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)42025

1 to 10 of 911Source NIH's project files

See all 911 nih grants

Papers1,338

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting PIM kinases in cancer and inflammatory disorders: From mechanisms to clinical translation.Eur J Med Chem202642822254PubTator, text miningPubMed
Machine learning-driven identification of PIM2 kinase inhibitors through QSAR modeling and molecular dynamics simulations.J Genet Eng Biotechnol202642749429PubTator, text miningPubMed
SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation.Proc Natl Acad Sci U S A202642636358PubTator, text miningPubMed
T Cell-associated Co-expression Module Genes as Prognostic Biomarkers and Predictors of Immunotherapy Response in Head and Neck Squamous Cell Carcinoma.Curr Med Chem202642634197PubTator, text miningPubMed
Comparative Analysis of LPS/IFN-γ and LPS/ATP-Induced Inflammatory Models in BV2 Microglia.Neurochem Res202642566061PubTator, text miningPubMed
In silico DFT study, molecular docking interactions, molecular dynamics and toxicological assessment of selected organochlorine-based pesticides.In Silico Pharmacol202642542631PubTator, text miningPubMed
PAWR augments anti-RNA viral innate immunity by promoting the PIM2-XBP1s-RIG-I signaling axis.Nat Commun202642277020PubTator, text miningPubMed
An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma.Cell Rep202642228563PubTator, text miningPubMed
Periodontal ligament stem cell-derived exosomal miR-378a programs osteogenic commitment via DAZAP2/SMAD signaling.Biochem Biophys Res Commun202642185189PubTator, text miningPubMed
An explainable ensemble machine learning framework for predicting cartilage biomechanical degradation from transcriptomic profiles: toward smart orthopedic device design.Front Bioeng Biotechnol202642147485PubTator, text miningPubMed

1 to 10 of 1,338

See all 1,338 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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