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Gene · 11073

TOPBP1: DNA topoisomerase II binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TOPBP1: DNA topoisomerase II binding protein 1. Genes, record 11073. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11073

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Gene

Symbol
TOPBP1
HGNC
Name
DNA topoisomerase II binding protein 1
HGNC
NCBI Gene ID
11073
NCBI Gene
HGNC ID
HGNC:17008
HGNC
Ensembl
ENSG00000163781
NCBI Gene
Aliases
Dpb11, KIAA0259, TOP2BP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92547DNA topoisomerase 2-binding protein 11,52217Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467245Q92547Espacenet
EP 4650780 A22025-11-191827Q92547Espacenet
EP 4641201 A22025-10-291411Q92547Espacenet
JP 2025517969 A2025-06-121411Q92547Espacenet
JP 2025517970 A2025-06-121827Q92547Espacenet
EP 4464338 A22024-11-20189Q92547Espacenet
US 11976334 B22024-05-07208Q92547Espacenet
US 11680268 B22023-06-20189Q92547Espacenet
US 11446398 B22022-09-2089218Q92547Espacenet
JP 2022524081 A2022-04-27192189Q92547Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,137

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTOPBP1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant292025
P30CA016059Massey Cancer Center - Cancer Center Support Grant162025
P01CA092584Structural Cell Biology of DNA Repair Machines122025
P30CA008748Cancer Center Support Grant122025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability122025
ZIAAG000753Fanconi Anemia Pathway122025
P30ES010126UNC Center for Environmental Health and Susceptibility102025
ZIABC010411Initiation of DNA Replication in Mammalian Cells92025
R01CA142861Renewal: HPV and the DNA Damage Response82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72025

1 to 10 of 1,137Source NIH's project files

See all 1,137 nih grants

Papers1,761

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DDIAS shields vulnerable single-stranded DNA to direct neurogenesis and protect cancer cells.Mol Cell202642822412PubTator, text miningPubMed
MCPH1 and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.Diagnostics (Basel)202642793752PubTator, text miningPubMed
Mechanistic insights into phosphorylation-driven activation and therapeutic inhibition of human ATR-ATRIP.Nat Struct Mol Biol202642754753PubTator, text miningPubMed
SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA-PKcs/CHK1 replicative checkpoint to inhibit cell growth in non-small cell lung cancer.Mol Oncol202642751865PubTator, text miningPubMed
The KEAP1-NFE2L2/NRF2 Axis in Non-Small Cell Lung Cancer Radioresistance: Redox Homeostasis and Emerging DNA Damage Response Mechanisms.Cancer Manag Res202642708106PubTator, text miningPubMed
Dynamic chromatin tethering of MDC1 regulates genome stability.Nucleic Acids Res202642703974PubTator, text miningPubMed
DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1.EMBO Rep202642661062PubTator, text miningPubMed
DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.Cell202642636811PubTator, text miningPubMed
Mitotic single-stranded DNA suppression by DDIAS.Mol Cell202642636809PubTator, text miningPubMed
Development of a structurally distinct TopBP1 inhibitor that enhances PARP blockade and reverses osimertinib resistance.Sci Adv202642555732PubTator, text miningPubMed

1 to 10 of 1,761

See all 1,761 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11073

GET https://conductscience.org/api/genes/v1/11073/patents