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Gene · 1108

CHD4: chromodomain helicase DNA binding protein 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHD4: chromodomain helicase DNA binding protein 4. Genes, record 1108. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1108

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Gene

Symbol
CHD4
HGNC
Name
chromodomain helicase DNA binding protein 4
HGNC
NCBI Gene ID
1108
NCBI Gene
HGNC ID
HGNC:1919
HGNC
Ensembl
ENSG00000111642
NCBI Gene
Aliases
CHD-4, Mi-2b, Mi2-BETA, SIHIWES
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14839ATP-dependent chromatin remodeler CHD41,91212Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-293040Q14839Espacenet
EP 4641201 A22025-10-2919596Q14839Espacenet
JP 2025519096 A2025-06-243040Q14839Espacenet
JP 2025517969 A2025-06-1219596Q14839Espacenet
JP 2024123008 A2024-09-105606Q14839Espacenet
US 11920164 B22024-03-0511Q14839Espacenet
JP 2023549761 A2023-11-29235Q14839Espacenet
JP 2022141755 A2022-09-29465Q14839Espacenet
US 11446398 B22022-09-2015267Q14839Espacenet
JP 2022524081 A2022-04-27118238Q14839Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,946

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHD4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant182025
ZIAES101965Eukaryotic Transcriptional Regulation152025
P30CA016672Cancer Center Support Grant142025
P30CA046934University of Colorado Cancer Center Support Grant122025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants92025
P30CA016059Massey Cancer Center - Cancer Center Support Grant82025
P30CA010815Consolidated Basic Cancer Research Program62025
P30CA042014Cancer Center Support Grant62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
P30AR070254Johns Hopkins Rheumatic Diseases Resource-based Core Center (Johns Hopkins RDRCC)52025

1 to 10 of 1,946Source NIH's project files

See all 1,946 nih grants

Papers2,308

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Chromodomain helicase DNA-binding proteins and orofacial cleft.J Res Med Sci202642808081PubTator, text miningPubMed
De novo chromatin remodelling variants in sporadic Chiari 1 malformation.Brain202642640505PubTator, text miningPubMed
Targeting HDAC and proteostasis to eradicate quiescent cancer cells.Cancer Gene Ther202642595792PubTator, text miningPubMed
Deubiquitinase USP22 maintains B cell homeostasis through the CHD4-CD19 signaling axis and is dysregulated in Kawasaki disease.Sci Bull (Beijing)202642586813PubTator, text miningPubMed
Motif-Cluster: Motif driven prioritization of transcription factor binding clusters.PLoS Comput Biol202642555666PubTator, text miningPubMed
Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells.bioRxiv202642539289PubTator, text miningPubMed
Genotypic and Phenotypic Profile of 50 Cases With Chromatin Remodeling Complexes-Related Neurological Disorders.CNS Neurosci Ther202642528014PubTator, text miningPubMed
Somatic Cancer Driver Mutation Analysis in Endometriosis with Tumor-like Presentations: A Case Series Study.Biomedicines202642512109PubTator, text miningPubMed
Exploring Targets for Heart Failure Using Mendelian Randomization, Colocalization, Summary Data-based Mendelian Randomization, and Drug Prediction.J Vis Exp202642507612PubTator, text miningPubMed
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.Cancer Cell202642468521PubTator, text miningPubMed

1 to 10 of 2,308

See all 2,308 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1108

GET https://conductscience.org/api/genes/v1/1108/patents?page=2