Gene · 1108
CHD4: chromodomain helicase DNA binding protein 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CHD4: chromodomain helicase DNA binding protein 4. Genes, record 1108. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1108
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14839 | ATP-dependent chromatin remodeler CHD4 | 1,912 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 3040 | Q14839 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 19596 | Q14839 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 3040 | Q14839 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 19596 | Q14839 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5606 | Q14839 | Espacenet |
| US 11920164 B2 | 2024-03-05 | 11 | Q14839 | Espacenet |
| JP 2023549761 A | 2023-11-29 | 235 | Q14839 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 465 | Q14839 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 15267 | Q14839 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 118238 | Q14839 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,946
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CHD4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 18 | 2025 |
| ZIAES101965 | Eukaryotic Transcriptional Regulation | 15 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 12 | 2025 |
| R01CA198279 | Shaping DNA Damage Response Networks Via Histone H2A Variants | 9 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 8 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 6 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 6 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 6 | 2025 |
| P30AR070254 | Johns Hopkins Rheumatic Diseases Resource-based Core Center (Johns Hopkins RDRCC) | 5 | 2025 |
1 to 10 of 1,946Source NIH's project files
See all 1,946 nih grantsPapers2,308
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Chromodomain helicase DNA-binding proteins and orofacial cleft. | J Res Med Sci | 2026 | 42808081 | PubTator, text mining | PubMed |
| De novo chromatin remodelling variants in sporadic Chiari 1 malformation. | Brain | 2026 | 42640505 | PubTator, text mining | PubMed |
| Targeting HDAC and proteostasis to eradicate quiescent cancer cells. | Cancer Gene Ther | 2026 | 42595792 | PubTator, text mining | PubMed |
| Deubiquitinase USP22 maintains B cell homeostasis through the CHD4-CD19 signaling axis and is dysregulated in Kawasaki disease. | Sci Bull (Beijing) | 2026 | 42586813 | PubTator, text mining | PubMed |
| Motif-Cluster: Motif driven prioritization of transcription factor binding clusters. | PLoS Comput Biol | 2026 | 42555666 | PubTator, text mining | PubMed |
| Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells. | bioRxiv | 2026 | 42539289 | PubTator, text mining | PubMed |
| Genotypic and Phenotypic Profile of 50 Cases With Chromatin Remodeling Complexes-Related Neurological Disorders. | CNS Neurosci Ther | 2026 | 42528014 | PubTator, text mining | PubMed |
| Somatic Cancer Driver Mutation Analysis in Endometriosis with Tumor-like Presentations: A Case Series Study. | Biomedicines | 2026 | 42512109 | PubTator, text mining | PubMed |
| Exploring Targets for Heart Failure Using Mendelian Randomization, Colocalization, Summary Data-based Mendelian Randomization, and Drug Prediction. | J Vis Exp | 2026 | 42507612 | PubTator, text mining | PubMed |
| CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. | Cancer Cell | 2026 | 42468521 | PubTator, text mining | PubMed |
1 to 10 of 2,308
See all 2,308 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1108
GET https://conductscience.org/api/genes/v1/1108/patents?page=2