Gene · 11091
WDR5: WD repeat domain 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. WDR5: WD repeat domain 5. Genes, record 11091. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11091
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P61964 | WD repeat-containing protein 5 | 334 | 198 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 7573 | P61964 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7573 | P61964 | Espacenet |
| JP 2023549761 A | 2023-11-29 | 369 | P61964 | Espacenet |
| KR 1020230051899 A | 2023-04-19 | 11 | P61964 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 97427 | P61964 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 200398 | P61964 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 12584 | P61964 | Espacenet |
| EP 3740568 A1 | 2020-11-25 | 1 | P61964 | Espacenet |
| JP 2019033757 A | 2019-03-07 | 24951 | P61964 | Espacenet |
| JP 2019033757 A | 2019-03-07 | 24952 | P61964 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,759
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | WDR5 papers | Newest fiscal year |
|---|---|---|---|
| R01CA200709 | Facilitated recruitment of MYC to chromatin by interaction with WDR5 | 22 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 20 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 19 | 2025 |
| T32CA119925 | Integrated Biological Systems Training in Oncology | 16 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 12 | 2025 |
| P50CA236733 | Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer | 12 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 9 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 9 | 2025 |
| R35CA197569 | Mutations of Chromatin and its Modifying Machineries in Malignancies | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
1 to 10 of 1,759Source NIH's project files
See all 1,759 nih grantsPapers2,554
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| PRMT5 promotes ferroptosis in cisplatin-induced acute kidney injury through WDR5/ACSL4 pathway. | Redox Biol | 2026 | 42826479 | PubTator, text mining | PubMed |
| Pro-GAT: Reconnecting Fragmented PROTACs Using Graph Attention Transformer. | J Chem Inf Model | 2026 | 42734562 | PubTator, text mining | PubMed |
| Promiscuous RNA binding by WDR5 remodels the KMT2A (MLL1) histone methyltransferase complex to an inactive state. | Mol Cell | 2026 | 42673957 | PubTator, text mining | PubMed |
| The ISL1-WDR5-H3K4me3-STC1 axis attenuates cerebral ischemia-reperfusion injury. | Int Immunopharmacol | 2026 | 42497659 | PubTator, text mining | PubMed |
| Site-Specific Hydrogen-Deuterium Exchange Mass Spectrometry for Deep Explorations of Dynamic Shifts in Protein-Drug Interactions. | J Am Chem Soc | 2026 | 42420201 | PubTator, text mining | PubMed |
| Role of thromboelastography in risk stratifying patients with traumatic brain injury on prehospital antiplatelet agents. | Trauma Surg Acute Care Open | 2026 | 42344540 | PubTator, text mining | PubMed |
| Epigenetic compartmentalization of mitotic chromosomes by phase-separation-driven repulsion between WDR5 and the chromosomal passenger complex. | Nat Commun | 2026 | 42303627 | PubTator, text mining | PubMed |
| Retrospective Validation of the Brain Injury Guidelines at a Single Community Institution. | Cureus | 2026 | 42255828 | PubTator, text mining | PubMed |
| Promiscuous RNA binding by WDR5 remodels the KMT2A (MLL1) histone methyltransferase complex to an inactive state. | bioRxiv | 2026 | 42239275 | PubTator, text mining | PubMed |
| Targeting the MYCN interaction network in neuroblastoma. | Biosci Rep | 2026 | 42233780 | PubTator, text mining | PubMed |
1 to 10 of 2,554
See all 2,554 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/11091
GET https://conductscience.org/api/genes/v1/11091/patents?page=2