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Gene · 11091

WDR5: WD repeat domain 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WDR5: WD repeat domain 5. Genes, record 11091. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11091

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Gene

Symbol
WDR5
HGNC
Name
WD repeat domain 5
HGNC
NCBI Gene ID
11091
NCBI Gene
HGNC ID
HGNC:12757
HGNC
Ensembl
ENSG00000196363
NCBI Gene
Aliases
BIG-3, BIG3, CFAP89, SWD3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61964WD repeat-containing protein 5334198Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197573P61964Espacenet
JP 2025517970 A2025-06-127573P61964Espacenet
JP 2023549761 A2023-11-29369P61964Espacenet
KR 1020230051899 A2023-04-1911P61964Espacenet
US 11446398 B22022-09-2097427P61964Espacenet
JP 2022524081 A2022-04-27200398P61964Espacenet
US 11078247 B22021-08-0312584P61964Espacenet
EP 3740568 A12020-11-251P61964Espacenet
JP 2019033757 A2019-03-0724951P61964Espacenet
JP 2019033757 A2019-03-0724952P61964Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,759

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWDR5 papersNewest fiscal year
R01CA200709Facilitated recruitment of MYC to chromatin by interaction with WDR5222025
P30CA008748Cancer Center Support Grant202025
P30CA068485Cancer Center Support Grant192025
T32CA119925Integrated Biological Systems Training in Oncology162025
P30EY008126Core Grant in Vision Research122025
P50CA236733Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer122025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92025
P30DK058404Molecular and Cellular Basis for Digestive Diseases92025
R35CA197569Mutations of Chromatin and its Modifying Machineries in Malignancies92025
P30CA016672Cancer Center Support Grant82025

1 to 10 of 1,759Source NIH's project files

See all 1,759 nih grants

Papers2,554

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PRMT5 promotes ferroptosis in cisplatin-induced acute kidney injury through WDR5/ACSL4 pathway.Redox Biol202642826479PubTator, text miningPubMed
Pro-GAT: Reconnecting Fragmented PROTACs Using Graph Attention Transformer.J Chem Inf Model202642734562PubTator, text miningPubMed
Promiscuous RNA binding by WDR5 remodels the KMT2A (MLL1) histone methyltransferase complex to an inactive state.Mol Cell202642673957PubTator, text miningPubMed
The ISL1-WDR5-H3K4me3-STC1 axis attenuates cerebral ischemia-reperfusion injury.Int Immunopharmacol202642497659PubTator, text miningPubMed
Site-Specific Hydrogen-Deuterium Exchange Mass Spectrometry for Deep Explorations of Dynamic Shifts in Protein-Drug Interactions.J Am Chem Soc202642420201PubTator, text miningPubMed
Role of thromboelastography in risk stratifying patients with traumatic brain injury on prehospital antiplatelet agents.Trauma Surg Acute Care Open202642344540PubTator, text miningPubMed
Epigenetic compartmentalization of mitotic chromosomes by phase-separation-driven repulsion between WDR5 and the chromosomal passenger complex.Nat Commun202642303627PubTator, text miningPubMed
Retrospective Validation of the Brain Injury Guidelines at a Single Community Institution.Cureus202642255828PubTator, text miningPubMed
Promiscuous RNA binding by WDR5 remodels the KMT2A (MLL1) histone methyltransferase complex to an inactive state.bioRxiv202642239275PubTator, text miningPubMed
Targeting the MYCN interaction network in neuroblastoma.Biosci Rep202642233780PubTator, text miningPubMed

1 to 10 of 2,554

See all 2,554 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11091

GET https://conductscience.org/api/genes/v1/11091/patents?page=2