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Gene · 112398

EGLN2: egl-9 family hypoxia inducible factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EGLN2: egl-9 family hypoxia inducible factor 2. Genes, record 112398. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/112398

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Gene

Symbol
EGLN2
HGNC
Name
egl-9 family hypoxia inducible factor 2
HGNC
NCBI Gene ID
112398
NCBI Gene
HGNC ID
HGNC:14660
HGNC
Ensembl
ENSG00000269858
NCBI Gene
Aliases
EIT-6, EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96KS0Prolyl hydroxylase EGLN24071Ensembl, GeneID, HGNC

Source UniProt

Patents96

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444807Q96KS0Espacenet
JP 2026004568 A2026-01-1444808Q96KS0Espacenet
EP 4650780 A22025-11-194470Q96KS0Espacenet
JP 2025517970 A2025-06-124470Q96KS0Espacenet
US 11446398 B22022-09-2026828Q96KS0Espacenet
US 11446398 B22022-09-2026829Q96KS0Espacenet
US 11446398 B22022-09-2026832Q96KS0Espacenet
JP 2022537339 A2022-08-2564Q96KS0Espacenet
JP 2022524081 A2022-04-27129799Q96KS0Espacenet
JP 2022524081 A2022-04-27129800Q96KS0Espacenet

1 to 10 of 96

See all 96 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DAPRODUSTATCHEMBL3544988Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL
MOLIDUSTATCHEMBL3646118Hypoxia-inducible factor prolyl hydroxylase 1 inhibitorINHIBITORChEMBL
ROXADUSTATCHEMBL2338329Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL
VADADUSTATCHEMBL3646221Hypoxia-inducible factor prolyl hydroxylase 1 inhibitorINHIBITORChEMBL

Trials113

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07565701VADADUSTATPHASE3ClinicalTrials.gov
NCT07537816VADADUSTATPHASE4ClinicalTrials.gov
NCT07359027ROXADUSTATPHASE4ClinicalTrials.gov
NCT07346547DAPRODUSTATClinicalTrials.gov
NCT07300111DAPRODUSTATPHASE3ClinicalTrials.gov
NCT07268807ROXADUSTATClinicalTrials.gov
NCT07136792ROXADUSTATClinicalTrials.gov
NCT07086755VADADUSTATPHASE2/PHASE3ClinicalTrials.gov
NCT07045155ROXADUSTATPHASE4ClinicalTrials.gov
NCT06917950ROXADUSTATPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 113

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NIH grants1,210

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEGLN2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA046934University of Colorado Cancer Center Support Grant72025
P50CA058223SPORE in Breast Cancer52025
R01AG067664Targeting acetylated histone H4 by MLL452025
R01CA252707Molecular analysis of ASH1L52025
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)42025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants42025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIAES101965Eukaryotic Transcriptional Regulation42025
I01BX002348Cellular and Molecular Mechanisms of Renal Anemia32025

1 to 10 of 1,210Source NIH's project files

See all 1,210 nih grants

Papers1,689

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer.Proc Natl Acad Sci U S A202642821343PubTator, text miningPubMed
Current insights into PHF14: molecular features and functional roles.Front Mol Biosci202642698416PubTator, text miningPubMed
Buspirone attenuates cyclophosphamide-induced renal dysfunction in association with alterations in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP signaling.Front Pharmacol202642694385PubTator, text miningPubMed
Post-Treatment Persistent Erythrocytosis in Patients with Hodgkin Lymphoma: Molecular Mechanisms Underlying the Pathogenesis of Erythrocytosis.Cancers (Basel)202642588719PubTator, text miningPubMed
Evolutionary convergence and niche-specific regulation of core HIF1A pathway genes synergistically drive divergent hypoxia adaptation in mammals.BMC Ecol Evol202642477533PubTator, text miningPubMed
PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression.Elife202642348440PubTator, text miningPubMed
Oncometabolite 2-hydroxyglutarate destabilizes CDH1 to regulate quiescence and enhance chemotherapy sensitivity.Cell Commun Signal202642271454PubTator, text miningPubMed
Comprehensive analysis of HB-PHD transcription factors associated with drought and salt stresses in wheat.BMC Genomics202642271227PubTator, text miningPubMed
HIF-1α Signaling in Uterine Fibroids: A Central Integrator of Hypoxic, Hormonal, and Fibrotic Pathways.Oxygen (Basel)202642181792PubTator, text miningPubMed
Chrysin reshapes ferroptosis sensitivity to reverse nickel refining fumes-induced lung injury via the miR-210/ANGPTL4 signaling axis mediated by the PHD1/HIF-1α pathway.Ecotoxicol Environ Saf202642127541PubTator, text miningPubMed

1 to 10 of 1,689

See all 1,689 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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