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Gene · 112399

EGLN3: egl-9 family hypoxia inducible factor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EGLN3: egl-9 family hypoxia inducible factor 3. Genes, record 112399. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/112399

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Gene

Symbol
EGLN3
HGNC
Name
egl-9 family hypoxia inducible factor 3
HGNC
NCBI Gene ID
112399
NCBI Gene
HGNC ID
HGNC:14661
HGNC
Ensembl
ENSG00000129521
NCBI Gene
Aliases
HIFP4H3, HIFPH3, PHD3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H6Z9Prolyl hydroxylase EGLN32390Ensembl, GeneID, HGNC

Source UniProt

Patents78

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444809Q9H6Z9Espacenet
JP 2026004568 A2026-01-1444810Q9H6Z9Espacenet
EP 4641201 A22025-10-29936Q9H6Z9Espacenet
EP 4641202 A22025-10-294447Q9H6Z9Espacenet
JP 2025517969 A2025-06-12936Q9H6Z9Espacenet
JP 2025032204 A2025-03-1127699Q9H6Z9Espacenet
WO 2025049599 A12025-03-064Q9H6Z9Espacenet
KR 1020250017231 A2025-02-044447Q9H6Z9Espacenet
EP 4487869 A22025-01-08149Q9H6Z9Espacenet
US 12188096 B22025-01-0756Q9H6Z9Espacenet

1 to 10 of 78

See all 78 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DAPRODUSTATCHEMBL3544988Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL
MOLIDUSTATCHEMBL3646118Egl nine homolog 3 inhibitorINHIBITORChEMBL
ROXADUSTATCHEMBL2338329Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL
VADADUSTATCHEMBL3646221Egl nine homolog 3 inhibitorINHIBITORChEMBL

Trials113

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07565701VADADUSTATPHASE3ClinicalTrials.gov
NCT07537816VADADUSTATPHASE4ClinicalTrials.gov
NCT07359027ROXADUSTATPHASE4ClinicalTrials.gov
NCT07346547DAPRODUSTATClinicalTrials.gov
NCT07300111DAPRODUSTATPHASE3ClinicalTrials.gov
NCT07268807ROXADUSTATClinicalTrials.gov
NCT07136792ROXADUSTATClinicalTrials.gov
NCT07086755VADADUSTATPHASE2/PHASE3ClinicalTrials.gov
NCT07045155ROXADUSTATPHASE4ClinicalTrials.gov
NCT06917950ROXADUSTATPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 113

See all 113 trials

NIH grants1,232

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEGLN3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)62025
P30CA008748Cancer Center Support Grant52025
P30CA016056Roswell Park Cancer Center Support Grant52025
UL1TR001863Yale Clinical and Translational Science Award52025
I01BX002182Metabolic Regulation of Mucosal Inflammation42025
P30CA016087Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants42025
R01DK095491Indole dysbiosis and mucosal inflammation42025

1 to 10 of 1,232Source NIH's project files

See all 1,232 nih grants

Papers2,134

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Potential Mechanisms Linking Excessive Testosterone to PMOS: Insights from Network Toxicology and Machine Learning.Metabolites202642783788PubTator, text miningPubMed
HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma.Mol Biomed202642726156PubTator, text miningPubMed
Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC.Exp Mol Med202642686983PubTator, text miningPubMed
Shikonin in Hepatocellular Carcinoma: Bridging Metabolic Disruption and Immunomodulation.J Hepatocell Carcinoma202642639556PubTator, text miningPubMed
Post-Treatment Persistent Erythrocytosis in Patients with Hodgkin Lymphoma: Molecular Mechanisms Underlying the Pathogenesis of Erythrocytosis.Cancers (Basel)202642588719PubTator, text miningPubMed
Mechanism of troxerutin-mediated regulation of EGLN3/LRPPRC in B[a]P-induced lung adenocarcinoma.Int Immunopharmacol202642556279PubTator, text miningPubMed
EPAS1 knockdown is associated with cell cycle and DNA replication programs and MYC/E2F-related signatures in hemangioma endothelial cells.PLoS One202642497216PubTator, text miningPubMed
Evolutionary convergence and niche-specific regulation of core HIF1A pathway genes synergistically drive divergent hypoxia adaptation in mammals.BMC Ecol Evol202642477533PubTator, text miningPubMed
Duodenal dysbiosis is linked to altered ferroportin related transcriptomics programs in iron deficiency anemia.Front Nutr202642459794PubTator, text miningPubMed
A mechanistic computational model of the HIF signaling pathway in endothelial cells.iScience202642291256PubTator, text miningPubMed

1 to 10 of 2,134

See all 2,134 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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