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Gene · 11251

PTGDR2: prostaglandin D2 receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTGDR2: prostaglandin D2 receptor 2. Genes, record 11251. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11251

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Gene

Symbol
PTGDR2
HGNC
Name
prostaglandin D2 receptor 2
HGNC
NCBI Gene ID
11251
NCBI Gene
HGNC ID
HGNC:4502
HGNC
Ensembl
ENSG00000183134
NCBI Gene
Aliases
CD294, CRTH2, DL1R, DP2, GPR44
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5Y4Prostaglandin D2 receptor 23956Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-295726Q9Y5Y4Espacenet
EP 4641202 A22025-10-29323Q9Y5Y4Espacenet
JP 2025529142 A2025-09-043618Q9Y5Y4Espacenet
US 12371689 B22025-07-293618Q9Y5Y4Espacenet
JP 2025517969 A2025-06-125726Q9Y5Y4Espacenet
KR 1020250017231 A2025-02-04323Q9Y5Y4Espacenet
EP 4491229 A22025-01-15205Q9Y5Y4Espacenet
WO 2024230934 A12024-11-14330Q9Y5Y4Espacenet
JP 2023153821 A2023-10-1836Q9Y5Y4Espacenet
US 11446398 B22022-09-2067447Q9Y5Y4Espacenet

1 to 10 of 32

See all 32 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADC3680CHEMBL3545343G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
AM-211CHEMBL2181753G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
AM-461CHEMBL5095021G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
ARRY-502CHEMBL5314403G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
AZD1981CHEMBL1914489G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
BI-671800CHEMBL551813G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
DONITRIPTANCHEMBL1742428G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
FEVIPIPRANTCHEMBL3137332G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
MK-1029CHEMBL3545031G protein-coupled receptor 44 antagonistANTAGONISTChEMBL
MK-7246CHEMBL561132G protein-coupled receptor 44 antagonistANTAGONISTChEMBL

1 to 10 of 16

See all 16 drugs

Trials53

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05706454RAMATROBANPHASE2/PHASE3ClinicalTrials.gov
NCT04049175TIMAPIPRANTPHASE3ClinicalTrials.gov
NCT03989635FEVIPIPRANTPHASE2ClinicalTrials.gov
NCT03810183FEVIPIPRANTPHASE22021-01-25ClinicalTrials.gov
NCT03681093FEVIPIPRANTPHASE32021-01-05ClinicalTrials.gov
NCT03650400FEVIPIPRANTPHASE22020-07-20ClinicalTrials.gov
NCT03629249FEVIPIPRANTPHASE32021-02-02ClinicalTrials.gov
NCT03226392FEVIPIPRANTPHASE32020-02-28ClinicalTrials.gov
NCT03215758FEVIPIPRANTPHASE32020-02-12ClinicalTrials.gov
NCT03052517FEVIPIPRANTPHASE32020-10-12ClinicalTrials.gov

1 to 10 of 53

See all 53 trials

NIH grants1,296

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTGDR2 papersNewest fiscal year
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma122025
U19AI070235Epithelial Genes in Allergic Inflammation112025
U01AI095608Regulation of mucosal immunity by neuronal pathways102025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease92025
P30ES007048Environmental Exposures, Host Factors and Human Disease92025
P30CA016058Cancer Center Support Grant72025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital72025
R01AI124355Genetic and Immunological Dissection of Eosinophilic Esophagitis72025
P30AI027763UCSF-Bay Area Center for AIDS Research62025
R01CA208353Elucidation of Human Natural Killer Cell Development62025

1 to 10 of 1,296Source NIH's project files

See all 1,296 nih grants

Papers2,267

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Immunometabolic Profiling of T Cells and Innate Lymphoid Cells Uncovers Therapeutic Targets to Enhance Immunotherapy in Head and Neck Cancer.Cancer Immunol Res202642804348PubTator, text miningPubMed
Machine learning reveals immune heterogeneity in recovery-phase samples of pediatric wheezing.Front Pediatr202642707154PubTator, text miningPubMed
A novel JAK1 mutation identified in a patient with severe atopic dermatitis phenotype: Mechanistic insights and IL-4Rα targeted therapy.Clin Immunol202642379330PubTator, text miningPubMed
The Pivotal Role of Plant Derivatives and Eicosanoid Signaling Modulation in Counteracting Cardiomiopathy.Int J Mol Sci202642278379PubTator, text miningPubMed
Stage-dependent interaction between circulating and tissue-resident memory CD4+ T cells in recurrent allergic airway inflammation.Inflamm Res202642228188PubTator, text miningPubMed
The PGD2/DP2 axis promotes pro-inflammatory responses but attenuates an antigen-presenting role of human basophils.Commun Biol202642162122PubTator, text miningPubMed
Transcriptomic Determinants of Circulating Immunity Predict Immune-Related Adverse Events (irAEs) in Cancer Patients Receiving PD-1/PD-L1 Blockade.Thorac Cancer202641920053PubTator, text miningPubMed
IDH1 Mutant Glioma Favors Group 3 Innate Lymphoid Cells and Is Resistant to Immune Checkpoint Expression.Inflamm Res202641917320PubTator, text miningPubMed
Involvement of increased arginase-1+ group 2 innate lymphoid cells and myeloid-derived suppressor cells in endometrial carcinoma: A pilot study.J Int Med Res202641912235PubTator, text miningPubMed
Tumor-infiltrating immature innate lymphoid cells in colorectal cancer are biased toward ILC1/tissue-resident NK cell differentiation.Nat Commun202641896575PubTator, text miningPubMed

1 to 10 of 2,267

See all 2,267 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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