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Gene · 11255

HRH3: histamine receptor H3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HRH3: histamine receptor H3. Genes, record 11255. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11255

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Gene

Symbol
HRH3
HGNC
Name
histamine receptor H3
HGNC
NCBI Gene ID
11255
NCBI Gene
HGNC ID
HGNC:5184
HGNC
Ensembl
ENSG00000101180
NCBI Gene
Aliases
GPCR97, HH3R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5N1Histamine H3 receptor4458Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1038Q9Y5N1Espacenet
EP 4641201 A22025-10-296520Q9Y5N1Espacenet
JP 2025529142 A2025-09-041984Q9Y5N1Espacenet
US 12371689 B22025-07-291984Q9Y5N1Espacenet
JP 2025517969 A2025-06-126520Q9Y5N1Espacenet
JP 2025032204 A2025-03-1129665Q9Y5N1Espacenet
EP 4461818 A22024-11-1329665Q9Y5N1Espacenet
JP 2023156353 A2023-10-2438Q9Y5N1Espacenet
JP 2023153821 A2023-10-1840Q9Y5N1Espacenet
JP 2023058610 A2023-04-2529665Q9Y5N1Espacenet

1 to 10 of 45

See all 45 patents

Drugs17

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-288CHEMBL3545029Histamine H3 receptor antagonistANTAGONISTChEMBL
BAVISANTCHEMBL2103862Histamine H3 receptor antagonistANTAGONISTChEMBL
BETAHISTINECHEMBL24441Histamine H3 receptor antagonistANTAGONISTChEMBL
CIPRALISANTCHEMBL278462Histamine H3 receptor agonistAGONISTChEMBL
CIPRALISANT MALEATECHEMBL2106003Histamine H3 receptor agonistAGONISTChEMBL
GSK-1004723CHEMBL1767164Histamine H3 receptor antagonistANTAGONISTChEMBL
GSK189254CHEMBL517140Histamine H3 receptor antagonistANTAGONISTChEMBL
GSK239512CHEMBL3092650Histamine H3 receptor antagonistANTAGONISTChEMBL
IRDABISANTCHEMBL1829335Histamine H3 receptor antagonistANTAGONISTChEMBL
JNJ-17216498CHEMBL3545030Histamine H3 receptor antagonistANTAGONISTChEMBL

1 to 10 of 17

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Trials63

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07540364SUVN-G3031PHASE3ClinicalTrials.gov
NCT07334002BETAHISTINEClinicalTrials.gov
NCT07219485PITOLISANTPHASE3ClinicalTrials.gov
NCT07051252PITOLISANTPHASE1ClinicalTrials.gov
NCT06544434BETAHISTINEPHASE2ClinicalTrials.gov
NCT06366464PITOLISANTPHASE3ClinicalTrials.gov
NCT06001593BETAHISTINEPHASE1/PHASE2ClinicalTrials.gov
NCT05953389PITOLISANTPHASE2ClinicalTrials.gov
NCT05530447SUVN-G3031ClinicalTrials.gov
NCT05458128PITOLISANTPHASE3ClinicalTrials.gov

1 to 10 of 63

See all 63 trials

NIH grants453

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHRH3 papersNewest fiscal year
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry42025
T32DK007664Research Training in Pediatrics Gastroenterolgy32025
P30DK056338Texas Medical Center Digestive Diseases Center22025
P30DK123704MUSC Digestive Disease Research Core Center22025
UL1TR001863Yale Clinical and Translational Science Award22025
ZIAMH002793PET Radiopharmaceutical Sciences22025
I01BX003380MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis12025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches12025
K01AG068366Alteration of sleep and cortical parvalbumin interneurons in mouse model of Alzheimers disease12025
K01DK128128Activation of C/EBP-β by mitohormesis as a therapy for obesity12025

1 to 10 of 453Source NIH's project files

See all 453 nih grants

Papers1,482

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploration of the therapeutic potential of the HRH3 histamine receptor in MECP2-related disorders.Neuropharmacology202642632612PubTator, text miningPubMed
Microbiota contributes to regulates the external genitalia development through gut-testis axis in male geese.Poult Sci202642617270PubTator, text miningPubMed
Synthesis and Biological Activity of Novel Aromatic Aminopropyl Lactams in Two Cancer Cell Models.ChemMedChem202642503046PubTator, text miningPubMed
OptoH3R fusion protein mimics β-arrestin-mediated membrane endocytosis of histamine H3 receptor in vitro.Mol Brain202642323615PubTator, text miningPubMed
Histamine shapes the neurocomputational dynamics of human learning.Nat Commun202642230645PubTator, text miningPubMed
Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk.BMC Psychiatry202642163165PubTator, text miningPubMed
Preclinical Evidence for Antidepressant-like Effects of Histamine H3 Receptor Modulation: A Systematic Review and Meta-Analysis.Life (Basel)202642073505PubTator, text miningPubMed
Substance P and somatostatin neurons limit facial itch by recruiting distinct nociceptive circuits in the brainstem.Commun Biol202642069949PubTator, text miningPubMed
Integrated chemometric modelling of histamine H3 receptor for the identification of ligands from a natural product repository.SAR QSAR Environ Res202642043907PubTator, text miningPubMed
Quantitative deciphering of mammalian histamine receptors through mathematical genomics.Biochem Biophys Res Commun202641946080PubTator, text miningPubMed

1 to 10 of 1,482

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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