Gene · 11255
HRH3: histamine receptor H3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HRH3: histamine receptor H3. Genes, record 11255. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11255
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y5N1 | Histamine H3 receptor | 445 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents45
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026062654 A | 2026-04-10 | 38 | Q9Y5N1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6520 | Q9Y5N1 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1984 | Q9Y5N1 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1984 | Q9Y5N1 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6520 | Q9Y5N1 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29665 | Q9Y5N1 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 29665 | Q9Y5N1 | Espacenet |
| JP 2023156353 A | 2023-10-24 | 38 | Q9Y5N1 | Espacenet |
| JP 2023153821 A | 2023-10-18 | 40 | Q9Y5N1 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 29665 | Q9Y5N1 | Espacenet |
1 to 10 of 45
See all 45 patentsDrugs17
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABT-288 | CHEMBL3545029 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
| BAVISANT | CHEMBL2103862 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
| BETAHISTINE | CHEMBL24441 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
| CIPRALISANT | CHEMBL278462 | Histamine H3 receptor agonist | AGONIST | ChEMBL |
| CIPRALISANT MALEATE | CHEMBL2106003 | Histamine H3 receptor agonist | AGONIST | ChEMBL |
| GSK-1004723 | CHEMBL1767164 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
| GSK189254 | CHEMBL517140 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
| GSK239512 | CHEMBL3092650 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
| IRDABISANT | CHEMBL1829335 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
| JNJ-17216498 | CHEMBL3545030 | Histamine H3 receptor antagonist | ANTAGONIST | ChEMBL |
1 to 10 of 17
See all 17 drugsTrials63
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07540364 | SUVN-G3031 | PHASE3 | ClinicalTrials.gov | |
| NCT07334002 | BETAHISTINE | ClinicalTrials.gov | ||
| NCT07219485 | PITOLISANT | PHASE3 | ClinicalTrials.gov | |
| NCT07051252 | PITOLISANT | PHASE1 | ClinicalTrials.gov | |
| NCT06544434 | BETAHISTINE | PHASE2 | ClinicalTrials.gov | |
| NCT06366464 | PITOLISANT | PHASE3 | ClinicalTrials.gov | |
| NCT06001593 | BETAHISTINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05953389 | PITOLISANT | PHASE2 | ClinicalTrials.gov | |
| NCT05530447 | SUVN-G3031 | ClinicalTrials.gov | ||
| NCT05458128 | PITOLISANT | PHASE3 | ClinicalTrials.gov |
1 to 10 of 63
See all 63 trialsNIH grants453
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HRH3 papers | Newest fiscal year |
|---|---|---|---|
| R25MH077823 | Research Education for Future Physician-Scientists in Child Psychiatry | 4 | 2025 |
| T32DK007664 | Research Training in Pediatrics Gastroenterolgy | 3 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 2 | 2025 |
| P30DK123704 | MUSC Digestive Disease Research Core Center | 2 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 2 | 2025 |
| ZIAMH002793 | PET Radiopharmaceutical Sciences | 2 | 2025 |
| I01BX003380 | MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis | 1 | 2025 |
| K01AA030083 | Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches | 1 | 2025 |
| K01AG068366 | Alteration of sleep and cortical parvalbumin interneurons in mouse model of Alzheimers disease | 1 | 2025 |
| K01DK128128 | Activation of C/EBP-β by mitohormesis as a therapy for obesity | 1 | 2025 |
1 to 10 of 453Source NIH's project files
See all 453 nih grantsPapers1,482
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exploration of the therapeutic potential of the HRH3 histamine receptor in MECP2-related disorders. | Neuropharmacology | 2026 | 42632612 | PubTator, text mining | PubMed |
| Microbiota contributes to regulates the external genitalia development through gut-testis axis in male geese. | Poult Sci | 2026 | 42617270 | PubTator, text mining | PubMed |
| Synthesis and Biological Activity of Novel Aromatic Aminopropyl Lactams in Two Cancer Cell Models. | ChemMedChem | 2026 | 42503046 | PubTator, text mining | PubMed |
| OptoH3R fusion protein mimics β-arrestin-mediated membrane endocytosis of histamine H3 receptor in vitro. | Mol Brain | 2026 | 42323615 | PubTator, text mining | PubMed |
| Histamine shapes the neurocomputational dynamics of human learning. | Nat Commun | 2026 | 42230645 | PubTator, text mining | PubMed |
| Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk. | BMC Psychiatry | 2026 | 42163165 | PubTator, text mining | PubMed |
| Preclinical Evidence for Antidepressant-like Effects of Histamine H3 Receptor Modulation: A Systematic Review and Meta-Analysis. | Life (Basel) | 2026 | 42073505 | PubTator, text mining | PubMed |
| Substance P and somatostatin neurons limit facial itch by recruiting distinct nociceptive circuits in the brainstem. | Commun Biol | 2026 | 42069949 | PubTator, text mining | PubMed |
| Integrated chemometric modelling of histamine H3 receptor for the identification of ligands from a natural product repository. | SAR QSAR Environ Res | 2026 | 42043907 | PubTator, text mining | PubMed |
| Quantitative deciphering of mammalian histamine receptors through mathematical genomics. | Biochem Biophys Res Commun | 2026 | 41946080 | PubTator, text mining | PubMed |
1 to 10 of 1,482
See all 1,482 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/11255
GET https://conductscience.org/api/genes/v1/11255/patents?page=2