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Gene · 11274

USP18: ubiquitin specific peptidase 18

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. USP18: ubiquitin specific peptidase 18. Genes, record 11274. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11274

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Gene

Symbol
USP18
HGNC
Name
ubiquitin specific peptidase 18
HGNC
NCBI Gene ID
11274
NCBI Gene
HGNC ID
HGNC:12616
HGNC
Ensembl
ENSG00000184979
NCBI Gene
Aliases
ISG43, PTORCH2, UBP43
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UMW8Ubl carboxyl-terminal hydrolase 183722Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468976Q9UMW8Espacenet
EP 4650780 A22025-11-19282Q9UMW8Espacenet
JP 2025517970 A2025-06-12282Q9UMW8Espacenet
US 11884978 B22024-01-30795Q9UMW8Espacenet
JP 2023551068 A2023-12-0636Q9UMW8Espacenet
JP 2023549761 A2023-11-2936Q9UMW8Espacenet
JP 2023549167 A2023-11-2236Q9UMW8Espacenet
JP 2023548973 A2023-11-2136Q9UMW8Espacenet
US 11686014 B22023-06-2732Q9UMW8Espacenet
US 11446398 B22022-09-2094791Q9UMW8Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,369

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUSP18 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success92025
R01AI127372Human ISG15 and USP18 Deficiencies Underlying Type I Interferonopathies82025
T32AI007647Training Program in Mechanisms of Virus-Host Interactions52025
P20GM103476Mississippi INBRE42025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center42025
P30CA023108Cancer Center Support Grant42025
R01AI095983Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial Disease42025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis42025
ZIAAI001059Defining New Human Immunodeficiency and Immunodysregulation Disorders42025

1 to 10 of 1,369Source NIH's project files

See all 1,369 nih grants

Papers1,718

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A novel stop-loss variant in ISG15 causes C-terminal dysfunction and impairs USP18-mediated negative feedback.Front Immunol202642824448PubTator, text miningPubMed
Sequential exposure to histological chorioamnionitis and postnatal hyperoxia alters gene expression in cord blood monocytes.Front Pediatr202642812615PubTator, text miningPubMed
Organelle-centered ISG15 biology: distinguishing covalent ISGylation from interferon-associated responses.Front Immunol202642757191PubTator, text miningPubMed
piRNA-46403 Promotes Sertoli Cell Ferroptosis via Disrupting m5C-dependent USP18 mRNA Stabilization in Varicocele-mediated Infertility.Int J Biol Sci202642695002PubTator, text miningPubMed
Regulators of interferon-responsive microglia uncovered by Genome-wide CRISPRi screening.NPJ Dement202642694111PubTator, text miningPubMed
Clinicopathological significance and exploratory prognostic modeling of USP18 and YBX3 expression in clear cell renal cell carcinoma: a retrospective Chinese cohort study.Front Oncol202642614232PubTator, text miningPubMed
SR-A3 Promotes USP18-Mediated deISGylation of STING to Protect Against Myocardial Ischemia-Reperfusion Injury.Adv Sci (Weinh)202642606110PubTator, text miningPubMed
Transcription factor EN1 governs a lipogenic USP18-ACLY axis to drive bladder cancer malignancy.Oncogene202642521834PubTator, text miningPubMed
Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2).J Exp Med202642461263PubTator, text miningPubMed
Repeated aminoglycoside exposure activates interferon-stimulated genes in human renal proximal tubular models.Arch Toxicol202642446670PubTator, text miningPubMed

1 to 10 of 1,718

See all 1,718 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11274

GET https://conductscience.org/api/genes/v1/11274/patents?page=2