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Gene · 11280

SCN11A: sodium voltage-gated channel alpha subunit 11

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCN11A: sodium voltage-gated channel alpha subunit 11. Genes, record 11280. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11280

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Gene

Symbol
SCN11A
HGNC
Name
sodium voltage-gated channel alpha subunit 11
HGNC
NCBI Gene ID
11280
NCBI Gene
HGNC ID
HGNC:10583
HGNC
Ensembl
ENSG00000168356
NCBI Gene
Aliases
FEPS3, HSAN7, NAV1.9, NaN, Nav1.9, PN5, SCN12A, SNS-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UI33Sodium channel protein type 11 subunit alpha1,7910Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463930Q9UI33Espacenet
JP 2026004568 A2026-01-1463932Q9UI33Espacenet
US 12516308 B22026-01-062437Q9UI33Espacenet
EP 4641201 A22025-10-294058Q9UI33Espacenet
JP 2025529142 A2025-09-043839Q9UI33Espacenet
US 12371689 B22025-07-293839Q9UI33Espacenet
JP 2025517969 A2025-06-124058Q9UI33Espacenet
JP 2024520478 A2024-05-2436Q9UI33Espacenet
US 11898179 B22024-02-132437Q9UI33Espacenet
US 11464217 B22022-10-1129Q9UI33Espacenet

1 to 10 of 48

See all 48 patents

Drugs84

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFACIFENACINCHEMBL3545165Sodium channel protein type XI alpha subunit blockerBLOCKERChEMBL
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 84

See all 84 drugs

Trials1,301

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants928

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCN11A papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award112025
I50RX002999Center for Restoration of Nervous System Function52025
R01NS034509Functional Genetics of the Neuronal Sodium Channel Gene SCN8A42025
P30CA016672Cancer Center Support Grant32025
R01AR060364Molecular Pathways of Pain Generation in Osteoarthritis32025
R01AR064251Osteoarthritis Progression And Sensory Pathway Alterations32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025
T32GM136651Medical Scientist Training Program32025
T32NS045549Interdisciplinary Training Program in Pain Research32025
U19NS130608Human Nociceptor and Spinal Cord Molecular Signature Center32025

1 to 10 of 928Source NIH's project files

See all 928 nih grants

Papers1,589

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Chasing the Wrong Door for 30 Years: Is Suzetrigine the Key to Selective Pain Relief?Medicina (Kaunas)202642796305PubTator, text miningPubMed
Cu Doping Activates SnS2 Basal Planes for Efficient CO2 Electroreduction to Formate.Langmuir202642714836PubTator, text miningPubMed
A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition.Cell Chem Biol202642679814PubTator, text miningPubMed
Nonaddictive Analgesia: New Approaches That Target the Hodgkin-Huxley NaV/KV Dyad.Annu Rev Pharmacol Toxicol202642594287PubTator, text miningPubMed
New insight into RNA biomarkers in neuropathic pain: a clinician-neuroscientist roadmap to translational testing and treatment monitoring a clinical review.Front Pain Res (Lausanne)202642534835PubTator, text miningPubMed
Magnetoelastic Transport-Path Reconstruction and Giant Magnetotransport Responses in a Two-Dimensional Antiferromagnet.Nano Lett202642503889PubTator, text miningPubMed
Phase-Restructured SnS2 Nanodots: Unlocking ORR Activity through Thermal Stress-Mediated Fracturing.Small202642434923PubTator, text miningPubMed
Gate-Tunable Magnetoresistance in Antiferromagnetic van der Waals FePS3 Transistors.Nano Lett202642407046PubTator, text miningPubMed
Isoform-Specific NaV Modulation in Painful Chemotherapy-Induced Neuropathy: Promise, Limitations, and a Clinical Agenda.CNS Drugs202642334794PubTator, text miningPubMed
Selectivity Reversal from CO to Ethylene Products in CO2 Photoreduction via Electronic Modulation of SnS2 Using a Vinyl-Bridged Porous Organic Polymer.J Am Chem Soc202642330158PubTator, text miningPubMed

1 to 10 of 1,589

See all 1,589 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11280

GET https://conductscience.org/api/genes/v1/11280/patents?page=2