Gene · 1133
CHRM5: cholinergic receptor muscarinic 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CHRM5: cholinergic receptor muscarinic 5. Genes, record 1133. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1133
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P08912 | Muscarinic acetylcholine receptor M5 | 532 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41220 | P08912 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 41221 | P08912 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10969 | P08912 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 930 | P08912 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 930 | P08912 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10969 | P08912 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 15025 | P08912 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 15027 | P08912 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3709 | P08912 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 117996 | P08912 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs9
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AFACIFENACIN | CHEMBL3545165 | Muscarinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| DAROTROPIUM | CHEMBL2365940 | Muscarinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| DAROTROPIUM BROMIDE | CHEMBL2308782 | Muscarinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| GLYCOPYRRONIUM | CHEMBL1201335 | Muscarinic acetylcholine receptor inhibitor | INHIBITOR | ChEMBL |
| GLYCOPYRRONIUM TOSYLATE | CHEMBL3707243 | Muscarinic acetylcholine receptor inhibitor | INHIBITOR | ChEMBL |
| SOFPIRONIUM | CHEMBL3707224 | Muscarinic acetylcholine receptor inhibitor | INHIBITOR | ChEMBL |
| SOFPIRONIUM BROMIDE | CHEMBL3707223 | Muscarinic acetylcholine receptor inhibitor | INHIBITOR | ChEMBL |
| TERODILINE | CHEMBL363295 | Muscarinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| TERODILINE HYDROCHLORIDE | CHEMBL539770 | Muscarinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
Trials88
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07541378 | GLYCOPYRRONIUM | ClinicalTrials.gov | ||
| NCT07525375 | GLYCOPYRRONIUM | PHASE2 | ClinicalTrials.gov | |
| NCT07489911 | GLYCOPYRRONIUM | ClinicalTrials.gov | ||
| NCT07414134 | GLYCOPYRRONIUM | ClinicalTrials.gov | ||
| NCT07073950 | GLYCOPYRRONIUM | PHASE4 | ClinicalTrials.gov | |
| NCT06905483 | GLYCOPYRRONIUM | PHASE4 | ClinicalTrials.gov | |
| NCT06531798 | GLYCOPYRRONIUM | PHASE4 | ClinicalTrials.gov | |
| NCT06511193 | GLYCOPYRRONIUM | ClinicalTrials.gov | ||
| NCT06368427 | GLYCOPYRRONIUM | ClinicalTrials.gov | ||
| NCT06283966 | GLYCOPYRRONIUM | PHASE3 | ClinicalTrials.gov |
1 to 10 of 88
See all 88 trialsNIH grants342
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CHRM5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 2 | 2025 |
| P01AI063302 | The intersection of innate and adaptive immunity to intracellular pathogens | 1 | 2025 |
| P20GM103499 | South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) | 1 | 2025 |
| P30AG072980 | Arizona Alzheimer's Disease Research Center | 1 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 1 | 2025 |
| P30CA014236 | Cancer Center Support Grant (CCSG) | 1 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 1 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 1 | 2025 |
| P42ES010356 | Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation | 1 | 2025 |
1 to 10 of 342Source NIH's project files
See all 342 nih grantsPapers368
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors. | Biochem J | 2026 | 42619181 | PubTator, text mining | PubMed |
| Structure-based prediction of muscarinic M1/M3 receptor antagonist activity: Curated dataset and scaffold-aware evaluation. | J Pharmacol Exp Ther | 2026 | 42308581 | PubTator, text mining | PubMed |
| Dequalinium-based bitopic ligands uncover distinct pharmacological modulation of muscarinic receptors. | Biochem Pharmacol | 2026 | 42061623 | PubTator, text mining | PubMed |
| Exploring Genetic Heterogeneity in Type 2 Diabetes Subtypes. | Genes (Basel) | 2025 | 41153348 | PubTator, text mining | PubMed |
| Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing. | Nat Commun | 2025 | 40593589 | PubTator, text mining | PubMed |
| Modulatory effects of M3 muscarinic acetylcholine receptor on inflammatory profiles of human memory T helper cells. | J Immunol | 2025 | 40405417 | PubTator, text mining | PubMed |
| Monoamine neurotransmitter-related gene-based genome-wide association study of low-dose ketamine in patients with treatment-resistant depression. | J Psychopharmacol | 2025 | 40129096 | PubTator, text mining | PubMed |
| Repurposing of dipeptidyl peptidase FDA-approved drugs in Alzheimer's disease using network pharmacology and in-silico approaches. | Comput Biol Chem | 2025 | 39938415 | PubTator, text mining | PubMed |
| Epigenetic Modification of Muscarinic Acetylcholine Receptors in Squamous Cell Carcinoma of the Head and Neck. | Anticancer Res | 2025 | 39740827 | PubTator, text mining | PubMed |
| The Role of Aryl Hydrocarbon Receptor in Bone Biology. | Int J Tryptophan Res | 2024 | 38757095 | PubTator, text mining | PubMed |
1 to 10 of 368
See all 368 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1133
GET https://conductscience.org/api/genes/v1/1133/patents?page=2