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Gene · 1133

CHRM5: cholinergic receptor muscarinic 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRM5: cholinergic receptor muscarinic 5. Genes, record 1133. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1133

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Gene

Symbol
CHRM5
HGNC
Name
cholinergic receptor muscarinic 5
HGNC
NCBI Gene ID
1133
NCBI Gene
HGNC ID
HGNC:1954
HGNC
Ensembl
ENSG00000184984
NCBI Gene
Aliases
HM5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08912Muscarinic acetylcholine receptor M55322Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441220P08912Espacenet
JP 2026004568 A2026-01-1441221P08912Espacenet
EP 4641201 A22025-10-2910969P08912Espacenet
JP 2025529142 A2025-09-04930P08912Espacenet
US 12371689 B22025-07-29930P08912Espacenet
JP 2025517969 A2025-06-1210969P08912Espacenet
US 11446398 B22022-09-2015025P08912Espacenet
US 11446398 B22022-09-2015027P08912Espacenet
US 11400116 B22022-08-023709P08912Espacenet
JP 2022524081 A2022-04-27117996P08912Espacenet

1 to 10 of 27

See all 27 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFACIFENACINCHEMBL3545165Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
DAROTROPIUMCHEMBL2365940Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
DAROTROPIUM BROMIDECHEMBL2308782Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
GLYCOPYRRONIUMCHEMBL1201335Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
GLYCOPYRRONIUM TOSYLATECHEMBL3707243Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
SOFPIRONIUMCHEMBL3707224Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
SOFPIRONIUM BROMIDECHEMBL3707223Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
TERODILINECHEMBL363295Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
TERODILINE HYDROCHLORIDECHEMBL539770Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL

Trials88

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07541378GLYCOPYRRONIUMClinicalTrials.gov
NCT07525375GLYCOPYRRONIUMPHASE2ClinicalTrials.gov
NCT07489911GLYCOPYRRONIUMClinicalTrials.gov
NCT07414134GLYCOPYRRONIUMClinicalTrials.gov
NCT07073950GLYCOPYRRONIUMPHASE4ClinicalTrials.gov
NCT06905483GLYCOPYRRONIUMPHASE4ClinicalTrials.gov
NCT06531798GLYCOPYRRONIUMPHASE4ClinicalTrials.gov
NCT06511193GLYCOPYRRONIUMClinicalTrials.gov
NCT06368427GLYCOPYRRONIUMClinicalTrials.gov
NCT06283966GLYCOPYRRONIUMPHASE3ClinicalTrials.gov

1 to 10 of 88

See all 88 trials

NIH grants342

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRM5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant32025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology22025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens12025
P20GM103499South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)12025
P30AG072980Arizona Alzheimer's Disease Research Center12025
P30CA008748Cancer Center Support Grant12025
P30CA014236Cancer Center Support Grant (CCSG)12025
P30CA068485Cancer Center Support Grant12025
P30EY008126Core Grant in Vision Research12025
P42ES010356Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation12025

1 to 10 of 342Source NIH's project files

See all 342 nih grants

Papers368

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors.Biochem J202642619181PubTator, text miningPubMed
Structure-based prediction of muscarinic M1/M3 receptor antagonist activity: Curated dataset and scaffold-aware evaluation.J Pharmacol Exp Ther202642308581PubTator, text miningPubMed
Dequalinium-based bitopic ligands uncover distinct pharmacological modulation of muscarinic receptors.Biochem Pharmacol202642061623PubTator, text miningPubMed
Exploring Genetic Heterogeneity in Type 2 Diabetes Subtypes.Genes (Basel)202541153348PubTator, text miningPubMed
Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing.Nat Commun202540593589PubTator, text miningPubMed
Modulatory effects of M3 muscarinic acetylcholine receptor on inflammatory profiles of human memory T helper cells.J Immunol202540405417PubTator, text miningPubMed
Monoamine neurotransmitter-related gene-based genome-wide association study of low-dose ketamine in patients with treatment-resistant depression.J Psychopharmacol202540129096PubTator, text miningPubMed
Repurposing of dipeptidyl peptidase FDA-approved drugs in Alzheimer's disease using network pharmacology and in-silico approaches.Comput Biol Chem202539938415PubTator, text miningPubMed
Epigenetic Modification of Muscarinic Acetylcholine Receptors in Squamous Cell Carcinoma of the Head and Neck.Anticancer Res202539740827PubTator, text miningPubMed
The Role of Aryl Hydrocarbon Receptor in Bone Biology.Int J Tryptophan Res202438757095PubTator, text miningPubMed

1 to 10 of 368

See all 368 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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