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Gene · 1134

CHRNA1: cholinergic receptor nicotinic alpha 1 subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRNA1: cholinergic receptor nicotinic alpha 1 subunit. Genes, record 1134. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1134

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Gene

Symbol
CHRNA1
HGNC
Name
cholinergic receptor nicotinic alpha 1 subunit
HGNC
NCBI Gene ID
1134
NCBI Gene
HGNC ID
HGNC:1955
HGNC
Ensembl
ENSG00000138435
NCBI Gene
Aliases
ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P02708Acetylcholine receptor subunit alpha45715Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026114898 A2026-07-0816P02708Espacenet
JP 2026004568 A2026-01-1441224P02708Espacenet
JP 2025539844 A2025-12-0953P02708Espacenet
EP 4650780 A22025-11-191836P02708Espacenet
KR 1020250115413 A2025-07-3053P02708Espacenet
JP 2025104819 A2025-07-1036P02708Espacenet
WO 2025143139 A2025-07-0336P02708Espacenet
JP 2025517970 A2025-06-121836P02708Espacenet
US 11685954 B22023-06-27166P02708Espacenet
US 11446398 B22022-09-2015030P02708Espacenet

1 to 10 of 28

See all 28 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATRACURIUMCHEMBL1360Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
ATRACURIUM BESYLATECHEMBL1200527Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUMCHEMBL1201248Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUM BESYLATECHEMBL1200641Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DECAMETHONIUMCHEMBL1190Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DECAMETHONIUM BROMIDECHEMBL1134Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DOXACURIUMCHEMBL1237123Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DOXACURIUM CHLORIDECHEMBL1237099Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINECHEMBL360055Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINE TRIETHIODIDECHEMBL1200993Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL

1 to 10 of 28

See all 28 drugs

Trials47

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants571

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRNA1 papersNewest fiscal year
U54NS115054Rare Disease Network for Myasthenia Gravis32025
P30CA008748Cancer Center Support Grant22025
P40OD010440Caenorhabditis Genetics Center22025
R01AI114780Mechanisms of autoimmunity in myasthenia gravis22025
T15LM007088Research Training in Biomedical Informatics and Data Science at Oregon Health & Science University22025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).22025
ZIACL090034Mechanisms of Pain and Immune Processes22025
ZIADE000704Clinical and Mechanistic Investigations of Salivary Gland Dysfunction22025
KL2TR001862Institutional Career Development Core12025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions12025

1 to 10 of 571Source NIH's project files

See all 571 nih grants

Papers889

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
NMJ-associated transcriptomic remodeling correlates with disease severity in juvenile dermatomyositis.Inflamm Res202642700229PubTator, text miningPubMed
Multi-omics identifies promoter methylation and gene expression changes associated with human skeletal muscle atrophy.Exp Physiol202642636425PubTator, text miningPubMed
CHRNA gene alterations in epilepsy: A systematic review of alpha subunit associations with ADSHE, SeLIE, and SeLECTS.Epilepsy Res202642607591PubTator, text miningPubMed
Integrative multi-omics and machine learning identify CHRNA1 putative circadian-immune hub in COPD.PLoS One202642536689PubTator, text miningPubMed
Congenital myasthenic syndromes in a Southeast Asian adult neurology clinic: a long road to diagnosis and therapy.BMC Neurol202642469681PubTator, text miningPubMed
Hsa_circ_0065149 mediates the ceRNA network pathway: Research on the mechanism regulating myasthenia gravis.J Mol Neurosci202642171932PubTator, text miningPubMed
Hidden diagnoses among patients with double seronegative myasthenia gravis.Front Neurol202641940306PubTator, text miningPubMed
Non-pterygium Escobar syndrome from compound-heterozygous CHRNG variants: genotype-phenotype insights.Hum Genome Var202641826296PubTator, text miningPubMed
Telitacicept for refractory AChR-positive generalized myasthenia gravis: a retrospective real-world study.Front Immunol202641737228PubTator, text miningPubMed
PGVDA: a pathway-aggregated genetic dosage framework for interpretable disease classification using machine learning.Brief Bioinform202641632594PubTator, text miningPubMed

1 to 10 of 889

See all 889 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1134

GET https://conductscience.org/api/genes/v1/1134/patents?page=2