Gene · 11343
MGLL: monoglyceride lipase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MGLL: monoglyceride lipase. Genes, record 11343. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11343
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99685 | Monoglyceride lipase | 303 | 30 | Ensembl, GeneID, HGNC |
Source UniProt
Patents59
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54062 | Q99685 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54063 | Q99685 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8690 | Q99685 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8691 | Q99685 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 31562 | Q99685 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 31570 | Q99685 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 8690 | Q99685 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 8691 | Q99685 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 8690 | Q99685 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 8691 | Q99685 | Espacenet |
1 to 10 of 59
See all 59 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ELCUBRAGISTAT | CHEMBL3945728 | Monoglyceride lipase inhibitor | INHIBITOR |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03625453 | ELCUBRAGISTAT | PHASE2 | ClinicalTrials.gov | |
| NCT03447756 | ELCUBRAGISTAT | PHASE1 | ClinicalTrials.gov | |
| NCT03138421 | ELCUBRAGISTAT | PHASE1 | ClinicalTrials.gov |
NIH grants1,525
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MGLL papers | Newest fiscal year |
|---|---|---|---|
| P01DA009158 | Endocannabinoid Active Sites as Therapeutic Targets | 25 | 2025 |
| ZIAAA000375 | Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury | 10 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30DK026743 | UCSF Liver Center | 5 | 2025 |
| R01MH107435 | 2-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptation | 5 | 2025 |
| T32DA007027 | Training in the pharmacology of abused drugs | 5 | 2025 |
| ZIAAA000351 | Endocannabinoids and the Control Of Behavior and Cardiovascular Function | 5 | 2025 |
| R01DA042157 | Cannabinoid Receptors and Associated Proteins-Renewal | 4 | 2025 |
| R01DK107451 | The role of AEG-1 in NASH and NASH-HCC | 4 | 2025 |
1 to 10 of 1,525Source NIH's project files
See all 1,525 nih grantsPapers2,780
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| E2F1 down-regulation promotes lipid droplet accumulation and endometriosis development through impaired MGLL-mediated lipid mobilization. | Clin Sci (Lond) | 2026 | 42803692 | PubTator, text mining | PubMed |
| Monoacylglycerol Lipase Inhibition by JZL184 Improves Neurological Outcomes and Survival after Cardiac Arrest via 2-AG-Mediated Restoration of Cerebral Microcirculation. | Cannabis Cannabinoid Res | 2026 | 42798153 | PubTator, text mining | PubMed |
| Tai Chi exercise of short duration alters circulating oxylipins in postmenopausal women: a pilot study. | Front Med (Lausanne) | 2026 | 42740961 | PubTator, text mining | PubMed |
| Lipase ITB 2.1: a structure- and function-validated model for anti-obesity drug screening. | Mol Divers | 2026 | 42732036 | PubTator, text mining | PubMed |
| Computational discovery and dynamic profiling of dual acetylcholinesterase and monoacylglycerol lipase inhibitors for Alzheimer's disease. | Mol Divers | 2026 | 42693315 | PubTator, text mining | PubMed |
| From Glycocode to Precision Oncology: Therapeutic Strategies Targeting Aberrant O-GalNAc Glycosylation in Cancer. | Chem Rev | 2026 | 42677388 | PubTator, text mining | PubMed |
| Chronic THC exposure modulates behavioral outcomes and endocannabinoid signaling in HIV-1 Tg26 mice in a sex-dependent manner. | Brain Res Bull | 2026 | 42660238 | PubTator, text mining | PubMed |
| Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis. | Eur Arch Psychiatry Clin Neurosci | 2026 | 42640306 | PubTator, text mining | PubMed |
| Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation. | ChemMedChem | 2026 | 42638513 | PubTator, text mining | PubMed |
| Advances in Small Molecule Research Targeting Monoacylglycerol Lipase in Drug Discovery. | Med Res Rev | 2026 | 42478312 | PubTator, text mining | PubMed |
1 to 10 of 2,780
See all 2,780 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/11343
GET https://conductscience.org/api/genes/v1/11343/patents?page=2