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Gene · 11343

MGLL: monoglyceride lipase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MGLL: monoglyceride lipase. Genes, record 11343. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11343

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Gene

Symbol
MGLL
HGNC
Name
monoglyceride lipase
HGNC
NCBI Gene ID
11343
NCBI Gene
HGNC ID
HGNC:17038
HGNC
Ensembl
ENSG00000074416
NCBI Gene
Aliases
HU-K5, HUK5, MAGL, MGL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99685Monoglyceride lipase30330Ensembl, GeneID, HGNC

Source UniProt

Patents59

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454062Q99685Espacenet
JP 2026004568 A2026-01-1454063Q99685Espacenet
JP 2025147176 A2025-10-068690Q99685Espacenet
JP 2025147176 A2025-10-068691Q99685Espacenet
JP 2025032204 A2025-03-1131562Q99685Espacenet
JP 2025032204 A2025-03-1131570Q99685Espacenet
JP 2025028160 A2025-02-288690Q99685Espacenet
JP 2025028160 A2025-02-288691Q99685Espacenet
KR 1020250010750 A2025-01-218690Q99685Espacenet
KR 1020250010750 A2025-01-218691Q99685Espacenet

1 to 10 of 59

See all 59 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ELCUBRAGISTATCHEMBL3945728Monoglyceride lipase inhibitorINHIBITOR

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03625453ELCUBRAGISTATPHASE2ClinicalTrials.gov
NCT03447756ELCUBRAGISTATPHASE1ClinicalTrials.gov
NCT03138421ELCUBRAGISTATPHASE1ClinicalTrials.gov

NIH grants1,525

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMGLL papersNewest fiscal year
P01DA009158Endocannabinoid Active Sites as Therapeutic Targets252025
ZIAAA000375Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury102025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology62025
P30CA008748Cancer Center Support Grant52025
P30DK026743UCSF Liver Center52025
R01MH1074352-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptation52025
T32DA007027Training in the pharmacology of abused drugs52025
ZIAAA000351Endocannabinoids and the Control Of Behavior and Cardiovascular Function52025
R01DA042157Cannabinoid Receptors and Associated Proteins-Renewal42025
R01DK107451The role of AEG-1 in NASH and NASH-HCC42025

1 to 10 of 1,525Source NIH's project files

See all 1,525 nih grants

Papers2,780

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
E2F1 down-regulation promotes lipid droplet accumulation and endometriosis development through impaired MGLL-mediated lipid mobilization.Clin Sci (Lond)202642803692PubTator, text miningPubMed
Monoacylglycerol Lipase Inhibition by JZL184 Improves Neurological Outcomes and Survival after Cardiac Arrest via 2-AG-Mediated Restoration of Cerebral Microcirculation.Cannabis Cannabinoid Res202642798153PubTator, text miningPubMed
Tai Chi exercise of short duration alters circulating oxylipins in postmenopausal women: a pilot study.Front Med (Lausanne)202642740961PubTator, text miningPubMed
Lipase ITB 2.1: a structure- and function-validated model for anti-obesity drug screening.Mol Divers202642732036PubTator, text miningPubMed
Computational discovery and dynamic profiling of dual acetylcholinesterase and monoacylglycerol lipase inhibitors for Alzheimer's disease.Mol Divers202642693315PubTator, text miningPubMed
From Glycocode to Precision Oncology: Therapeutic Strategies Targeting Aberrant O-GalNAc Glycosylation in Cancer.Chem Rev202642677388PubTator, text miningPubMed
Chronic THC exposure modulates behavioral outcomes and endocannabinoid signaling in HIV-1 Tg26 mice in a sex-dependent manner.Brain Res Bull202642660238PubTator, text miningPubMed
Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis.Eur Arch Psychiatry Clin Neurosci202642640306PubTator, text miningPubMed
Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation.ChemMedChem202642638513PubTator, text miningPubMed
Advances in Small Molecule Research Targeting Monoacylglycerol Lipase in Drug Discovery.Med Res Rev202642478312PubTator, text miningPubMed

1 to 10 of 2,780

See all 2,780 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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