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Gene · 1140

CHRNB1: cholinergic receptor nicotinic beta 1 subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRNB1: cholinergic receptor nicotinic beta 1 subunit. Genes, record 1140. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1140

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Gene

Symbol
CHRNB1
HGNC
Name
cholinergic receptor nicotinic beta 1 subunit
HGNC
NCBI Gene ID
1140
NCBI Gene
HGNC ID
HGNC:1961
HGNC
Ensembl
ENSG00000170175
NCBI Gene
Aliases
ACHRB, CHRNB, CMS1D, CMS2A, CMS2C, SCCMS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P11230Acetylcholine receptor subunit beta50113Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441246P11230Espacenet
EP 4670794 A22025-12-3126P11230Espacenet
EP 4650780 A22025-11-194263P11230Espacenet
EP 4641201 A22025-10-293823P11230Espacenet
US 12435124 B22025-10-0733P11230Espacenet
JP 2025147176 A2025-10-062879P11230Espacenet
JP 2025529142 A2025-09-04940P11230Espacenet
JP 2025529142 A2025-09-045872P11230Espacenet
US 12371689 B22025-07-295872P11230Espacenet
US 12371689 B22025-07-29940P11230Espacenet

1 to 10 of 43

See all 43 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATRACURIUMCHEMBL1360Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
ATRACURIUM BESYLATECHEMBL1200527Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUMCHEMBL1201248Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUM BESYLATECHEMBL1200641Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DECAMETHONIUMCHEMBL1190Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DECAMETHONIUM BROMIDECHEMBL1134Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DOXACURIUMCHEMBL1237123Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DOXACURIUM CHLORIDECHEMBL1237099Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINECHEMBL360055Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINE TRIETHIODIDECHEMBL1200993Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL

1 to 10 of 28

See all 28 drugs

Trials47

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants314

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRNB1 papersNewest fiscal year
F30DA059437Subcortical targets involved in the action of psilocybin in learned and innate escape behaviors22025
P30CA068485Cancer Center Support Grant22025
P30EY008126Core Grant in Vision Research22025
T32GM007454Medical Genetics Postdoctoral Fellowship22025
U54NS115054Rare Disease Network for Myasthenia Gravis22025
UL1TR001863Yale Clinical and Translational Science Award22025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches12025
KL2TR001862Institutional Career Development Core12025
P01AG036695Molecular Regulation of Stem Cell Aging12025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes12025

1 to 10 of 314Source NIH's project files

See all 314 nih grants

Papers367

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Differential DNA Methylation and Delirium After Anesthesia and Surgery.medRxiv202642369472PubTator, text miningPubMed
Postsynaptic Congenital Myasthenic Syndrome Mimicking Limb-Girdle Muscular Dystrophy Associated with an Alternatively Spliced Exon in CHRNB1: A Case Report and Literature Review.Children (Basel)202642354011PubTator, text miningPubMed
Non-pterygium Escobar syndrome from compound-heterozygous CHRNG variants: genotype-phenotype insights.Hum Genome Var202641826296PubTator, text miningPubMed
Genetic Architecture of Myopia and Its Implications for Risk Stratification and Prognosis.Diagnostics (Basel)202641750685PubTator, text miningPubMed
Exploring molecular signatures in PURA syndrome using muscle proteomics and serum biomarkers.J Neurol202641575592PubTator, text miningPubMed
Comprehensive Genome-Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases.Brain Behav202541277170PubTator, text miningPubMed
Precision Target Discovery for Migraine: An Integrated GWAS-eQTL-PheWAS Pipeline.Molecules202541097341PubTator, text miningPubMed
Biallelic CRELD1 variants cause severe muscle weakness and infantile epilepsy.Brain Commun202540980404PubTator, text miningPubMed
Clinical and genetic features of congenital myasthenic syndrome due to the muscle acetylcholine receptor genes.Brain Dev202540768883PubTator, text miningPubMed
Causal Variants in CHRNA1 and CHRNB1 Genes for Anti-acetylcholine Receptor Antibody Positive Myasthenia Gravis: Evidence from Bayesian Fine-Mapping and Genetic Association Study.Mol Neurobiol202540279038PubTator, text miningPubMed

1 to 10 of 367

See all 367 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1140

GET https://conductscience.org/api/genes/v1/1140/patents?page=2