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Gene · 1144

CHRND: cholinergic receptor nicotinic delta subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRND: cholinergic receptor nicotinic delta subunit. Genes, record 1144. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1144

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Gene

Symbol
CHRND
HGNC
Name
cholinergic receptor nicotinic delta subunit
HGNC
NCBI Gene ID
1144
NCBI Gene
HGNC ID
HGNC:1965
HGNC
Ensembl
ENSG00000135902
NCBI Gene
Aliases
ACHRD, CMS2A, CMS3A, CMS3B, CMS3C, FCCMS, SCCMS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07001Acetylcholine receptor subunit delta51713Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441252Q07001Espacenet
EP 4670794 A22025-12-3127Q07001Espacenet
EP 4650780 A22025-11-191682Q07001Espacenet
JP 2025147176 A2025-10-062887Q07001Espacenet
JP 2025529142 A2025-09-04944Q07001Espacenet
JP 2025529142 A2025-09-045873Q07001Espacenet
US 12371689 B22025-07-295873Q07001Espacenet
US 12371689 B22025-07-29944Q07001Espacenet
JP 2025517970 A2025-06-121682Q07001Espacenet
EP 4551941 A22025-05-1449Q07001Espacenet

1 to 10 of 38

See all 38 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATRACURIUMCHEMBL1360Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
ATRACURIUM BESYLATECHEMBL1200527Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUMCHEMBL1201248Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUM BESYLATECHEMBL1200641Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DECAMETHONIUMCHEMBL1190Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DECAMETHONIUM BROMIDECHEMBL1134Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DOXACURIUMCHEMBL1237123Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DOXACURIUM CHLORIDECHEMBL1237099Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINECHEMBL360055Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINE TRIETHIODIDECHEMBL1200993Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL

1 to 10 of 28

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Trials47

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants256

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRND papersNewest fiscal year
F30DA059437Subcortical targets involved in the action of psilocybin in learned and innate escape behaviors22025
P30CA076292Moffitt Cancer Center Support Grant22025
P50AA012870Center for the Translational Neuroscience of Alcoholism22025
DP1DA058737Deciphering the single-nucleus genomic regulatory structure of opioid use disorder in the human brain12025
I01BX004820Genetic Vulnerability for Sustained Multi-Substance Use in MVP12025
KL2TR001862Institutional Career Development Core12025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology12025
P30CA008748Cancer Center Support Grant12025
P30CA016056Roswell Park Cancer Center Support Grant12025
P30CA023108Cancer Center Support Grant12025

1 to 10 of 256Source NIH's project files

See all 256 nih grants

Papers294

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical Variability and Genotype-Driven Outcomes in CHRND-Related Congenital Myasthenic Syndrome.Eur J Neurol202642657756PubTator, text miningPubMed
Integrative network pharmacology, transcriptomics, and molecular docking identify candidate Centella asiatica constituents and targets in neurodegenerative diseases.PLoS One202642536688PubTator, text miningPubMed
Systematic reanalysis of next-generation sequencing data in 101 neuromuscular disorder families enhances diagnostic yield, reveals intronic variants, and identifies a novel disease gene.J Neurol202642474733PubTator, text miningPubMed
Suspected Adult-Onset Congenital Myasthenic Syndrome Associated With a Heterozygous CHRND Variant in a Patient With Seropositive Rheumatoid Arthritis: A Case Report.Am J Case Rep202642324739PubTator, text miningPubMed
Non-pterygium Escobar syndrome from compound-heterozygous CHRNG variants: genotype-phenotype insights.Hum Genome Var202641826296PubTator, text miningPubMed
Exploring molecular signatures in PURA syndrome using muscle proteomics and serum biomarkers.J Neurol202641575592PubTator, text miningPubMed
Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.Transl Psychiatry202541052974PubTator, text miningPubMed
Biallelic CRELD1 variants cause severe muscle weakness and infantile epilepsy.Brain Commun202540980404PubTator, text miningPubMed
Slow-Channel Congenital Myasthenic Syndrome Due to CHRND Mutation in South Korea.J Clin Neurol202540878311PubTator, text miningPubMed
Persistent Inflammation, Maladaptive Remodeling, and Fibrosis in the Kidney Following Long COVID-like MHV-1 Mouse Model.Diseases202540863220PubTator, text miningPubMed

1 to 10 of 294

See all 294 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1144

GET https://conductscience.org/api/genes/v1/1144/patents?page=2