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Gene · 1145

CHRNE: cholinergic receptor nicotinic epsilon subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRNE: cholinergic receptor nicotinic epsilon subunit. Genes, record 1145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1145

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Gene

Symbol
CHRNE
HGNC
Name
cholinergic receptor nicotinic epsilon subunit
HGNC
NCBI Gene ID
1145
NCBI Gene
HGNC ID
HGNC:1966
HGNC
Ensembl
ENSG00000108556
NCBI Gene
Aliases
ACHRE, CMS1A1, CMS1D, CMS1E, CMS2A, CMS4A, CMS4B, CMS4C, FCCMS, FIM1, FIMG, FIMG1, MGI, SCCMS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q04844Acetylcholine receptor subunit epsilon49313Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441257Q04844Espacenet
EP 4670794 A22025-12-3123Q04844Espacenet
EP 4650780 A22025-11-1919657Q04844Espacenet
EP 4641201 A22025-10-2925455Q04844Espacenet
JP 2025529142 A2025-09-04945Q04844Espacenet
US 12371689 B22025-07-29945Q04844Espacenet
JP 2025517969 A2025-06-1225455Q04844Espacenet
JP 2025517970 A2025-06-1219657Q04844Espacenet
EP 4551941 A22025-05-1448Q04844Espacenet
US 12011480 B22024-06-1823Q04844Espacenet

1 to 10 of 27

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Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATRACURIUMCHEMBL1360Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
ATRACURIUM BESYLATECHEMBL1200527Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUMCHEMBL1201248Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
CISATRACURIUM BESYLATECHEMBL1200641Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DECAMETHONIUMCHEMBL1190Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DECAMETHONIUM BROMIDECHEMBL1134Muscle-type nicotinic acetylcholine receptor partial agonistPARTIAL AGONISTChEMBL
DOXACURIUMCHEMBL1237123Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
DOXACURIUM CHLORIDECHEMBL1237099Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINECHEMBL360055Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL
GALLAMINE TRIETHIODIDECHEMBL1200993Muscle-type nicotinic acetylcholine receptor antagonistANTAGONISTChEMBL

1 to 10 of 28

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Trials47

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants260

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRNE papersNewest fiscal year
P30CA033572Cancer Center Support Grant22025
R01AG076901Multiomics data integration methods to discover putative causal variants, genes and patient heterogeneity for Alzheimers disease22025
R01AG086467FunGen-xQTL: Unraveling the genetic basis of molecular functions in Alzheimer's Disease22025
R01HL153814Dissecting heterogeneity of excessive daytime sleepiness and impact on cardiovascular diseases22025
UL1TR001863Yale Clinical and Translational Science Award22025
ZIAES049019Genetic And Environmental Factors In Childhood Respiratory and Allergic Illness22025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches12025
K23HL166960Cell-Specific Transcriptional Programs in Cardiac Allograft Vasculopathy12025
KL2TR001862Institutional Career Development Core12025
P30CA008748Cancer Center Support Grant12025

1 to 10 of 260Source NIH's project files

See all 260 nih grants

Papers471

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Congenital myasthenic syndromes in Türkiye: genetic and clinical spectrum revisited in a nationwide pediatric cohort.Neuromuscul Disord202642727323PubTator, text miningPubMed
Pragmatic Phenotype-Electrophysiology-Genomics Integration in Pediatric Congenital Myasthenic Syndromes: Insights From 36 Patients in a Single-Center Study in China.CNS Neurosci Ther202642699991PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
The Differing Phenotypes of the Three Most Common Postsynaptic Congenital Myasthenic Syndromes Governed by Their Underlying Molecular Pathogenic Mechanisms.Muscle Nerve202642383519PubTator, text miningPubMed
Phenotypic Diversity in Pediatric Congenital Myasthenic Syndrome: Insights from CHRNE and DPAGT1 Variants.Neurol Int202642347111PubTator, text miningPubMed
Correction to: Clarifications to "Congenital myasthenia syndrome with demyelinating sensorimotor neuropathy responsive to salbutamol monotherapy: a novel clinical phenotype of CHRNE mutation": the usefulness of single-fiber electromyography (SFEMG).
Neurol Sci202642002656PubTator, text miningPubMed
Clarifications to "Congenital myasthenia syndrome with demyelinating sensorimotor neuropathy responsive to salbutamol monotherapy: a novel clinical phenotype of CHRNE mutation": the usefulness of single-fiber electromyography (SFEMG).
Neurol Sci202641906040PubTator, text miningPubMed
Exploring molecular signatures in PURA syndrome using muscle proteomics and serum biomarkers.J Neurol202641575592PubTator, text miningPubMed
Congenital Myasthenic Syndrome: Long-Term Outcomes up to 60 Years, Molecular Characterization, and Eight Novel Variants.Clin Genet202641451794PubTator, text miningPubMed
Identification of endoplasmic reticulum stress-related genes associated with Alzheimer's disease risk: A multi-omics Mendelian randomization analysis.J Affect Disord202641314550PubTator, text miningPubMed

1 to 10 of 471

See all 471 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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