Gene · 1145
CHRNE: cholinergic receptor nicotinic epsilon subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CHRNE: cholinergic receptor nicotinic epsilon subunit. Genes, record 1145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1145
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q04844 | Acetylcholine receptor subunit epsilon | 493 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41257 | Q04844 | Espacenet |
| EP 4670794 A2 | 2025-12-31 | 23 | Q04844 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19657 | Q04844 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25455 | Q04844 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 945 | Q04844 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 945 | Q04844 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 25455 | Q04844 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19657 | Q04844 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 48 | Q04844 | Espacenet |
| US 12011480 B2 | 2024-06-18 | 23 | Q04844 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs28
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ATRACURIUM | CHEMBL1360 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| ATRACURIUM BESYLATE | CHEMBL1200527 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| CISATRACURIUM | CHEMBL1201248 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| CISATRACURIUM BESYLATE | CHEMBL1200641 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| DECAMETHONIUM | CHEMBL1190 | Muscle-type nicotinic acetylcholine receptor partial agonist | PARTIAL AGONIST | ChEMBL |
| DECAMETHONIUM BROMIDE | CHEMBL1134 | Muscle-type nicotinic acetylcholine receptor partial agonist | PARTIAL AGONIST | ChEMBL |
| DOXACURIUM | CHEMBL1237123 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| DOXACURIUM CHLORIDE | CHEMBL1237099 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| GALLAMINE | CHEMBL360055 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| GALLAMINE TRIETHIODIDE | CHEMBL1200993 | Muscle-type nicotinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
1 to 10 of 28
See all 28 drugsTrials47
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07271472 | ROCURONIUM | ClinicalTrials.gov | ||
| NCT07143799 | CISATRACURIUM | ClinicalTrials.gov | ||
| NCT07121699 | ROCURONIUM | ClinicalTrials.gov | ||
| NCT07035301 | ROCURONIUM | ClinicalTrials.gov | ||
| NCT07033442 | ROCURONIUM | ClinicalTrials.gov | ||
| NCT06714981 | ROCURONIUM BROMIDE | ClinicalTrials.gov | ||
| NCT06514209 | CISATRACURIUM | ClinicalTrials.gov | ||
| NCT06214169 | CISATRACURIUM | ClinicalTrials.gov | ||
| NCT06212492 | CISATRACURIUM | ClinicalTrials.gov | ||
| NCT06203405 | CISATRACURIUM | ClinicalTrials.gov |
1 to 10 of 47
See all 47 trialsNIH grants260
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CHRNE papers | Newest fiscal year |
|---|---|---|---|
| P30CA033572 | Cancer Center Support Grant | 2 | 2025 |
| R01AG076901 | Multiomics data integration methods to discover putative causal variants, genes and patient heterogeneity for Alzheimers disease | 2 | 2025 |
| R01AG086467 | FunGen-xQTL: Unraveling the genetic basis of molecular functions in Alzheimer's Disease | 2 | 2025 |
| R01HL153814 | Dissecting heterogeneity of excessive daytime sleepiness and impact on cardiovascular diseases | 2 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 2 | 2025 |
| ZIAES049019 | Genetic And Environmental Factors In Childhood Respiratory and Allergic Illness | 2 | 2025 |
| K01AA030083 | Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches | 1 | 2025 |
| K23HL166960 | Cell-Specific Transcriptional Programs in Cardiac Allograft Vasculopathy | 1 | 2025 |
| KL2TR001862 | Institutional Career Development Core | 1 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 1 | 2025 |
1 to 10 of 260Source NIH's project files
See all 260 nih grantsPapers471
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Congenital myasthenic syndromes in Türkiye: genetic and clinical spectrum revisited in a nationwide pediatric cohort. | Neuromuscul Disord | 2026 | 42727323 | PubTator, text mining | PubMed |
| Pragmatic Phenotype-Electrophysiology-Genomics Integration in Pediatric Congenital Myasthenic Syndromes: Insights From 36 Patients in a Single-Center Study in China. | CNS Neurosci Ther | 2026 | 42699991 | PubTator, text mining | PubMed |
| Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation. | Circ Res | 2026 | 42594169 | PubTator, text mining | PubMed |
| The Differing Phenotypes of the Three Most Common Postsynaptic Congenital Myasthenic Syndromes Governed by Their Underlying Molecular Pathogenic Mechanisms. | Muscle Nerve | 2026 | 42383519 | PubTator, text mining | PubMed |
| Phenotypic Diversity in Pediatric Congenital Myasthenic Syndrome: Insights from CHRNE and DPAGT1 Variants. | Neurol Int | 2026 | 42347111 | PubTator, text mining | PubMed |
Correction to: Clarifications to "Congenital myasthenia syndrome with demyelinating sensorimotor neuropathy responsive to salbutamol monotherapy: a novel clinical phenotype of CHRNE mutation": the usefulness of single-fiber electromyography (SFEMG). | Neurol Sci | 2026 | 42002656 | PubTator, text mining | PubMed |
Clarifications to "Congenital myasthenia syndrome with demyelinating sensorimotor neuropathy responsive to salbutamol monotherapy: a novel clinical phenotype of CHRNE mutation": the usefulness of single-fiber electromyography (SFEMG). | Neurol Sci | 2026 | 41906040 | PubTator, text mining | PubMed |
| Exploring molecular signatures in PURA syndrome using muscle proteomics and serum biomarkers. | J Neurol | 2026 | 41575592 | PubTator, text mining | PubMed |
| Congenital Myasthenic Syndrome: Long-Term Outcomes up to 60 Years, Molecular Characterization, and Eight Novel Variants. | Clin Genet | 2026 | 41451794 | PubTator, text mining | PubMed |
| Identification of endoplasmic reticulum stress-related genes associated with Alzheimer's disease risk: A multi-omics Mendelian randomization analysis. | J Affect Disord | 2026 | 41314550 | PubTator, text mining | PubMed |
1 to 10 of 471
See all 471 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1145
GET https://conductscience.org/api/genes/v1/1145/patents?page=2