Gene · 120227
CYP2R1: cytochrome P450 family 2 subfamily R member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CYP2R1: cytochrome P450 family 2 subfamily R member 1. Genes, record 120227. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/120227
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q6VVX0 | Vitamin D 25-hydroxylase | 501 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 42881 | Q6VVX0 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6112 | Q6VVX0 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3896 | Q6VVX0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6102 | Q6VVX0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6102 | Q6VVX0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6112 | Q6VVX0 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 3896 | Q6VVX0 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 3896 | Q6VVX0 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 3903 | Q6VVX0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 21988 | Q6VVX0 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,019
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CYP2R1 papers | Newest fiscal year |
|---|---|---|---|
| R01AR073004 | Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin | 21 | 2025 |
| I01BX004293 | CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer | 18 | 2025 |
| ZIAES101586 | Nuclear receptors: action, functions, and roles in disease | 8 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 6 | 2025 |
| R01DK112955 | Repurposing rifampin to reduce elevated levels of blood and urine calcium in patients with inactivating mutations of CYP24A1 | 6 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 5 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 4 | 2025 |
| T32CA009001 | Program for Training in Cancer Epidemiology | 4 | 2025 |
| U01CA167552 | Cancer Epidemiology Cohort in Male Health Professionals | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
1 to 10 of 1,019Source NIH's project files
See all 1,019 nih grantsPapers1,899
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Vitamin D metabolites, genetic variants, and risk of cardiovascular diseases among individuals with newly diagnosed type 2 diabetes: a prospective study. | Food Funct | 2026 | 42751891 | PubTator, text mining | PubMed |
| Association of CYP2R1 gene polymorphisms with type 2 diabetes mellitus in the Jordanian population. | J Genet Eng Biotechnol | 2026 | 42749425 | PubTator, text mining | PubMed |
| Association of rs10741657 polymorphism in CYP2R1 gene with apparently healthy vitamin-D deficient Pakistani subjects. | J Pak Med Assoc | 2026 | 42703112 | PubTator, text mining | PubMed |
| Intervention methods and influencing factors of vitamin D deficiency in Northeast China: a self-controlled trial and randomized controlled trial study. | Front Nutr | 2026 | 42609231 | PubTator, text mining | PubMed |
| Beyond VDR: Vitamin D Metabolism Genes in Tuberculosis Susceptibility, Immune Response and Implications for Diabetes Mellitus. | Infect Drug Resist | 2026 | 42604156 | PubTator, text mining | PubMed |
| Genetic determinants of response to vitamin D supplementation. | Front Nutr | 2026 | 42528639 | PubTator, text mining | PubMed |
| Global Genetic Variation in Circulating 25-Hydroxyvitamin D: A Systematic Review of GWAS Evidence Across Different Ancestral Groups. | Nutrients | 2026 | 42451056 | PubTator, text mining | PubMed |
| From the Vitamin D Paradox to Precision Nutrition: Targeted Supplementation, Assay Pitfalls, and Clinical Decision-Making. | Curr Nutr Rep | 2026 | 42397501 | PubTator, text mining | PubMed |
| Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women. | Front Med (Lausanne) | 2026 | 42292230 | PubTator, text mining | PubMed |
Genetic association and computational analysis of CYP2R1 gene polymorphisms rs2060793 and rs12794714 with vitamin D deficiency and acute myocardial infarction in the Bangladeshi population: A case control study. | PLoS One | 2026 | 42247388 | PubTator, text mining | PubMed |
1 to 10 of 1,899
See all 1,899 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/120227
GET https://conductscience.org/api/genes/v1/120227/patents?page=2