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Gene · 120227

CYP2R1: cytochrome P450 family 2 subfamily R member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP2R1: cytochrome P450 family 2 subfamily R member 1. Genes, record 120227. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/120227

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Gene

Symbol
CYP2R1
HGNC
Name
cytochrome P450 family 2 subfamily R member 1
HGNC
NCBI Gene ID
120227
NCBI Gene
HGNC ID
HGNC:20580
HGNC
Ensembl
ENSG00000186104
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q6VVX0Vitamin D 25-hydroxylase5013Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442881Q6VVX0Espacenet
EP 4650780 A22025-11-196112Q6VVX0Espacenet
JP 2025147176 A2025-10-063896Q6VVX0Espacenet
JP 2025529142 A2025-09-046102Q6VVX0Espacenet
US 12371689 B22025-07-296102Q6VVX0Espacenet
JP 2025517970 A2025-06-126112Q6VVX0Espacenet
JP 2025028160 A2025-02-283896Q6VVX0Espacenet
KR 1020250010750 A2025-01-213896Q6VVX0Espacenet
JP 2024109657 A2024-08-143903Q6VVX0Espacenet
US 11446398 B22022-09-2021988Q6VVX0Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,019

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP2R1 papersNewest fiscal year
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin212025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer182025
ZIAES101586Nuclear receptors: action, functions, and roles in disease82025
P30DK063491Diabetes Research Center (DRC)62025
R01DK112955Repurposing rifampin to reduce elevated levels of blood and urine calcium in patients with inactivating mutations of CYP24A162025
P30CA013148Comprehensive Cancer Center Support Grant52025
P30CA023108Cancer Center Support Grant42025
T32CA009001Program for Training in Cancer Epidemiology42025
U01CA167552Cancer Epidemiology Cohort in Male Health Professionals42025
UL1TR001863Yale Clinical and Translational Science Award42025

1 to 10 of 1,019Source NIH's project files

See all 1,019 nih grants

Papers1,899

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Vitamin D metabolites, genetic variants, and risk of cardiovascular diseases among individuals with newly diagnosed type 2 diabetes: a prospective study.Food Funct202642751891PubTator, text miningPubMed
Association of CYP2R1 gene polymorphisms with type 2 diabetes mellitus in the Jordanian population.J Genet Eng Biotechnol202642749425PubTator, text miningPubMed
Association of rs10741657 polymorphism in CYP2R1 gene with apparently healthy vitamin-D deficient Pakistani subjects.J Pak Med Assoc202642703112PubTator, text miningPubMed
Intervention methods and influencing factors of vitamin D deficiency in Northeast China: a self-controlled trial and randomized controlled trial study.Front Nutr202642609231PubTator, text miningPubMed
Beyond VDR: Vitamin D Metabolism Genes in Tuberculosis Susceptibility, Immune Response and Implications for Diabetes Mellitus.Infect Drug Resist202642604156PubTator, text miningPubMed
Genetic determinants of response to vitamin D supplementation.Front Nutr202642528639PubTator, text miningPubMed
Global Genetic Variation in Circulating 25-Hydroxyvitamin D: A Systematic Review of GWAS Evidence Across Different Ancestral Groups.Nutrients202642451056PubTator, text miningPubMed
From the Vitamin D Paradox to Precision Nutrition: Targeted Supplementation, Assay Pitfalls, and Clinical Decision-Making.Curr Nutr Rep202642397501PubTator, text miningPubMed
Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women.Front Med (Lausanne)202642292230PubTator, text miningPubMed
Genetic association and computational analysis of CYP2R1 gene polymorphisms rs2060793 and rs12794714 with vitamin D deficiency and acute myocardial infarction in the Bangladeshi population: A case control study.
PLoS One202642247388PubTator, text miningPubMed

1 to 10 of 1,899

See all 1,899 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/120227

GET https://conductscience.org/api/genes/v1/120227/patents?page=2