Gene · 121278
TPH2: tryptophan hydroxylase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TPH2: tryptophan hydroxylase 2. Genes, record 121278. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/121278
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8IWU9 | Tryptophan 5-hydroxylase 2 | 490 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68408 | Q8IWU9 | Espacenet |
| US 11866749 B2 | 2024-01-09 | 3 | Q8IWU9 | Espacenet |
| JP 2023519296 A | 2023-05-10 | 70 | Q8IWU9 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 93133 | Q8IWU9 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 196104 | Q8IWU9 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 11895 | Q8IWU9 | Espacenet |
| US 11060063 B2 | 2021-07-13 | 105 | Q8IWU9 | Espacenet |
| US 10851365 B2 | 2020-12-01 | 3 | Q8IWU9 | Espacenet |
| US 10597685 B2 | 2020-03-24 | 3 | Q8IWU9 | Espacenet |
| US 10487314 B2 | 2019-11-26 | 105 | Q8IWU9 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials14
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04810091 | TELOTRISTAT ETHYL | PHASE3 | 2026-02-05 | ClinicalTrials.gov |
| NCT04776876 | TELOTRISTAT ETHYL | PHASE2 | ClinicalTrials.gov | |
| NCT04713202 | TELOTRISTAT ETHYL | PHASE2 | ClinicalTrials.gov | |
| NCT04543955 | TELOTRISTAT | PHASE2 | 2023-06-27 | ClinicalTrials.gov |
| NCT04065165 | TELOTRISTAT ETHYL | PHASE3 | ClinicalTrials.gov | |
| NCT04034745 | TELOTRISTAT ETHYL | ClinicalTrials.gov | ||
| NCT03910387 | TELOTRISTAT ETHYL | PHASE2 | 2025-12-16 | ClinicalTrials.gov |
| NCT03790111 | TELOTRISTAT ETHYL | PHASE2 | 2023-04-19 | ClinicalTrials.gov |
| NCT03453489 | TELOTRISTAT | PHASE2 | 2025-04-10 | ClinicalTrials.gov |
| NCT03223428 | TELOTRISTAT ETHYL | 2024-07-15 | ClinicalTrials.gov |
1 to 10 of 14
See all 14 trialsNIH grants1,495
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TPH2 papers | Newest fiscal year |
|---|---|---|---|
| P51OD011092 | Support for National Primate Research Center | 14 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 9 | 2025 |
| ZIAMH002927 | Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders | 5 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| ZIAMH002843 | Identification of Genes Involved in Major Mood Disorders | 4 | 2025 |
| ZIAMH002844 | Genetic Determinants of Antidepressant Response | 4 | 2025 |
| I01BX004293 | CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer | 3 | 2025 |
| P30AG066512 | Alzheimer's Disease Research Center - Administrative Supplement 2025 | 3 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 3 | 2025 |
| R01AR073004 | Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin | 3 | 2025 |
1 to 10 of 1,495Source NIH's project files
See all 1,495 nih grantsPapers2,066
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Vitamin D and Postpartum Depression: A Narrative Review. | Clin Pract | 2026 | 42645143 | PubTator, text mining | PubMed |
| Extrafollicular Tph2-like cell dominant tissue pathotype is associated with relapse in IgG4-related disease. | Rheumatology (Oxford) | 2026 | 42587431 | PubTator, text mining | PubMed |
| Association of TPH2 polymorphisms with valproic acid efficacy and neurological adverse events in pediatric epilepsy. | Front Pharmacol | 2026 | 42516558 | PubTator, text mining | PubMed |
| Genetic variation associated with depression in Latin American populations: a systematic review of single-nucleotide variants. | Front Psychiatry | 2026 | 42368811 | PubTator, text mining | PubMed |
| Pathways and Genetic Determinants of Impulse Control Disorders in Parkinson's Disease. | Life (Basel) | 2026 | 42355425 | PubTator, text mining | PubMed |
| Association Between Low Vitamin D Levels and Depression: A Systematic Review and Meta-Analysis. | Cureus | 2026 | 42338858 | PubTator, text mining | PubMed |
| Brain Serotonin Deficiency Impairs Ovarian Reserve Function via the Hypothalamic-Pituitary-Ovarian Axis. | Neurosci Bull | 2026 | 42184065 | PubTator, text mining | PubMed |
Serotonin's fundamental role in early social development: Socio-affective communication through ultrasonic vocalizations, maternal affiliation, and the bidirectional nature of mother-infant interactions. | Neurosci Biobehav Rev | 2026 | 42134428 | PubTator, text mining | PubMed |
| Genetic Risk and High Burden of Depression and Suicide in the Maya-Mestizo Population of Yucatán, México. | Am J Med Genet B Neuropsychiatr Genet | 2026 | 41968289 | PubTator, text mining | PubMed |
| Serotonin Associated Mechanisms in Sudden Unexpected Death in Epilepsy: A Review. | Rev Neurol | 2026 | 41914335 | PubTator, text mining | PubMed |
1 to 10 of 2,066
See all 2,066 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/121278
GET https://conductscience.org/api/genes/v1/121278/patents?page=2