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Gene · 121278

TPH2: tryptophan hydroxylase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPH2: tryptophan hydroxylase 2. Genes, record 121278. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/121278

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Gene

Symbol
TPH2
HGNC
Name
tryptophan hydroxylase 2
HGNC
NCBI Gene ID
121278
NCBI Gene
HGNC ID
HGNC:20692
HGNC
Ensembl
ENSG00000139287
NCBI Gene
Aliases
ADHD7, FLJ37295, NTPH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IWU9Tryptophan 5-hydroxylase 24905Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468408Q8IWU9Espacenet
US 11866749 B22024-01-093Q8IWU9Espacenet
JP 2023519296 A2023-05-1070Q8IWU9Espacenet
US 11446398 B22022-09-2093133Q8IWU9Espacenet
JP 2022524081 A2022-04-27196104Q8IWU9Espacenet
US 11078247 B22021-08-0311895Q8IWU9Espacenet
US 11060063 B22021-07-13105Q8IWU9Espacenet
US 10851365 B22020-12-013Q8IWU9Espacenet
US 10597685 B22020-03-243Q8IWU9Espacenet
US 10487314 B22019-11-26105Q8IWU9Espacenet

1 to 10 of 24

See all 24 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TELOTRISTATCHEMBL2103855Tryptophan 5-hydroxylase inhibitorINHIBITORChEMBL
TELOTRISTAT ETHYLCHEMBL2105695Tryptophan 5-hydroxylase inhibitorINHIBITORChEMBL
TELOTRISTAT ETIPRATECHEMBL3348963Tryptophan 5-hydroxylase inhibitorINHIBITORChEMBL

Trials14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04810091TELOTRISTAT ETHYLPHASE32026-02-05ClinicalTrials.gov
NCT04776876TELOTRISTAT ETHYLPHASE2ClinicalTrials.gov
NCT04713202TELOTRISTAT ETHYLPHASE2ClinicalTrials.gov
NCT04543955TELOTRISTATPHASE22023-06-27ClinicalTrials.gov
NCT04065165TELOTRISTAT ETHYLPHASE3ClinicalTrials.gov
NCT04034745TELOTRISTAT ETHYLClinicalTrials.gov
NCT03910387TELOTRISTAT ETHYLPHASE22025-12-16ClinicalTrials.gov
NCT03790111TELOTRISTAT ETHYLPHASE22023-04-19ClinicalTrials.gov
NCT03453489TELOTRISTATPHASE22025-04-10ClinicalTrials.gov
NCT03223428TELOTRISTAT ETHYL2024-07-15ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

NIH grants1,495

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPH2 papersNewest fiscal year
P51OD011092Support for National Primate Research Center142025
ZIAAA000301Integrative genetics of behavior with high throughput technologies92025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders52025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
ZIAMH002843Identification of Genes Involved in Major Mood Disorders42025
ZIAMH002844Genetic Determinants of Antidepressant Response42025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer32025
P30AG066512Alzheimer's Disease Research Center - Administrative Supplement 202532025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology32025
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin32025

1 to 10 of 1,495Source NIH's project files

See all 1,495 nih grants

Papers2,066

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Vitamin D and Postpartum Depression: A Narrative Review.Clin Pract202642645143PubTator, text miningPubMed
Extrafollicular Tph2-like cell dominant tissue pathotype is associated with relapse in IgG4-related disease.Rheumatology (Oxford)202642587431PubTator, text miningPubMed
Association of TPH2 polymorphisms with valproic acid efficacy and neurological adverse events in pediatric epilepsy.Front Pharmacol202642516558PubTator, text miningPubMed
Genetic variation associated with depression in Latin American populations: a systematic review of single-nucleotide variants.Front Psychiatry202642368811PubTator, text miningPubMed
Pathways and Genetic Determinants of Impulse Control Disorders in Parkinson's Disease.Life (Basel)202642355425PubTator, text miningPubMed
Association Between Low Vitamin D Levels and Depression: A Systematic Review and Meta-Analysis.Cureus202642338858PubTator, text miningPubMed
Brain Serotonin Deficiency Impairs Ovarian Reserve Function via the Hypothalamic-Pituitary-Ovarian Axis.Neurosci Bull202642184065PubTator, text miningPubMed
Serotonin's fundamental role in early social development: Socio-affective communication through ultrasonic vocalizations, maternal affiliation, and the bidirectional nature of mother-infant interactions.
Neurosci Biobehav Rev202642134428PubTator, text miningPubMed
Genetic Risk and High Burden of Depression and Suicide in the Maya-Mestizo Population of Yucatán, México.Am J Med Genet B Neuropsychiatr Genet202641968289PubTator, text miningPubMed
Serotonin Associated Mechanisms in Sudden Unexpected Death in Epilepsy: A Review.Rev Neurol202641914335PubTator, text miningPubMed

1 to 10 of 2,066

See all 2,066 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/121278

GET https://conductscience.org/api/genes/v1/121278/patents?page=2