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Gene · 1241

LTB4R: leukotriene B4 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LTB4R: leukotriene B4 receptor. Genes, record 1241. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1241

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Gene

Symbol
LTB4R
HGNC
Name
leukotriene B4 receptor
HGNC
NCBI Gene ID
1241
NCBI Gene
HGNC ID
HGNC:6713
HGNC
Ensembl
ENSG00000213903
NCBI Gene
Aliases
BLT1, BLTR, CMKRL1, GPR16, LTB4R1, LTBR1, P2RY7, P2Y7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15722Leukotriene B4 receptor 13522Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451643Q15722Espacenet
JP 2026004568 A2026-01-1451644Q15722Espacenet
JP 2026004568 A2026-01-1451645Q15722Espacenet
JP 2025529142 A2025-09-042487Q15722Espacenet
US 12371689 B22025-07-292487Q15722Espacenet
US 11446398 B22022-09-2046551Q15722Espacenet
US 11446398 B22022-09-2046552Q15722Espacenet
US 11446398 B22022-09-2046553Q15722Espacenet
US 11400116 B22022-08-021736Q15722Espacenet
US 11400116 B22022-08-026619Q15722Espacenet

1 to 10 of 52

See all 52 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMELUBANTCHEMBL1742420Leukotriene B4 receptor 1 antagonistANTAGONISTChEMBL
CP-195543CHEMBL301829Leukotriene B4 receptor antagonistANTAGONISTChEMBL
ETALOCIBCHEMBL329123Leukotriene B4 receptor 1 antagonistANTAGONISTChEMBL
NOMACOPANCHEMBL4297928Leukotriene B4 receptor inhibitorINHIBITORChEMBL

Trials16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05061771NOMACOPANPHASE3ClinicalTrials.gov
NCT04784455NOMACOPANPHASE32025-05-15ClinicalTrials.gov
NCT04037891NOMACOPANPHASE1/PHASE22025-02-27ClinicalTrials.gov
NCT04035733NOMACOPANPHASE2ClinicalTrials.gov
NCT03829449NOMACOPANPHASE32025-03-12ClinicalTrials.gov
NCT03588026NOMACOPANPHASE3ClinicalTrials.gov
NCT03427060NOMACOPANPHASE22025-05-04ClinicalTrials.gov
NCT02591862NOMACOPANPHASE22023-07-12ClinicalTrials.gov
NCT02251210AMELUBANTPHASE2ClinicalTrials.gov
NCT02249338AMELUBANTPHASE2ClinicalTrials.gov

1 to 10 of 16

See all 16 trials

NIH grants1,080

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLTB4R papersNewest fiscal year
R35GM128641Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation42025
T32AI060519Immunology and Infectious Diseases Training Program42025
P01HL116263HDL Function in Human Disease32025
P30CA008748Cancer Center Support Grant32025
P30ES010126UNC Center for Environmental Health and Susceptibility32025
R01AR062173The IL-23/IL-17 Axis in Inflammatory Arthritis32025
R35GM139430Evaluating Resolution Mechanisms for Infectious Inflammation32025
ZIABC011763Regulation of epithelial cell fate decisions in tissue homeostasis and cancer32025
P30CA010815Consolidated Basic Cancer Research Program22025
P30CA014599Cancer Center Support Grant22025

1 to 10 of 1,080Source NIH's project files

See all 1,080 nih grants

Papers1,557

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-Cell RNA Sequencing Combined with MEBOCOST Reveals Alveolar Macrophage-Mediated Immunometabolic Communication Mechanisms in Sepsis-Induced Acute Lung Injury.Genes (Basel)202642792913PubTator, text miningPubMed
The 5-Lipoxygenase Pathway in Ovarian Cancer: Mechanisms of Metastasis, Chemoresistance, and Translational Targeting.Int J Womens Health202642763661PubTator, text miningPubMed
Benzo[a]pyrene-induced METTL3 overexpression accelerates renal cell carcinoma progression via m6A modification of LTB4R mRNA and enhanced Treg infiltration.Ecotoxicol Environ Saf202642628180PubTator, text miningPubMed
In vivo CRISPR screening identifies LTA4H as a target for potentiating immunotherapy efficacy via the LTB4-neutrophil axis.Int Immunopharmacol202642537346PubTator, text miningPubMed
Identification of immune-related prognostic genes and construction of a risk model for Wilms tumor: A retrospective bioinformatics study.Medicine (Baltimore)202642499033PubTator, text miningPubMed
Mechanisms by which macrophage Ltb4r1 mediates tubular epithelial cell injury to facilitate the advancement of diabetic kidney disease.BMC Nephrol202642420893PubTator, text miningPubMed
Redox-sensitive GPCR signaling drives Gq-dependent Ca2+ mobilization and cytokine production in human bronchial epithelial cells.Am J Physiol Cell Physiol202642314770PubTator, text miningPubMed
Crosstalk between immune and programmed cell death and their application in colorectal cancer risk stratification.Mol Clin Oncol202642124937PubTator, text miningPubMed
Ochratoxin A and Clear Cell Renal Cell Carcinoma: Exploring Potential Molecular Links Through Network Toxicology and Machine Learning.Int J Mol Sci202641977161PubTator, text miningPubMed
Bach2 antagonizes leukotriene B4-Ltb4r1-JunB signaling to constrain Tfh13 cell differentiation.Cell Rep202641950005PubTator, text miningPubMed

1 to 10 of 1,557

See all 1,557 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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