Gene · 125
ADH1B: alcohol dehydrogenase 1B (class I), beta polypeptide
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ADH1B: alcohol dehydrogenase 1B (class I), beta polypeptide. Genes, record 125. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/125
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P00325 | Alcohol dehydrogenase 1B | 375 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36966 | P00325 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4429 | P00325 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 3918 | P00325 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 585 | P00325 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 24347 | P00325 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3976 | P00325 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 585 | P00325 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 3918 | P00325 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3976 | P00325 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 24347 | P00325 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05517668 | FOMEPIZOLE | PHASE2 | ClinicalTrials.gov | |
| NCT00661141 | FOMEPIZOLE | PHASE2 | 2017-09-15 | ClinicalTrials.gov |
| NCT00346853 | FOMEPIZOLE | PHASE1 | ClinicalTrials.gov |
NIH grants1,880
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ADH1B papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 70 | 2025 |
| P60AA007611 | Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol | 33 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 20 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 18 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 17 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 17 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 15 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| T32AA013525 | Alcohol Research in the Science/Practitioner Model | 8 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 7 | 2025 |
1 to 10 of 1,880Source NIH's project files
See all 1,880 nih grantsPapers2,710
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome-Wide Association Studies. | Genet Epidemiol | 2026 | 42820398 | PubTator, text mining | PubMed |
| Network toxicology and machine learning analysis of MC-LR-associated hepatocellular carcinoma. | J Environ Sci Health B | 2026 | 42811799 | PubTator, text mining | PubMed |
| ADH1B and ALDH2 polymorphisms and restless legs syndrome during pregnancy: A cross-sectional study during 2023-2025. | Sleep Med | 2026 | 42715881 | PubTator, text mining | PubMed |
| Teachable Moments in Alcohol-Related Diseases: A Practical Framework for Promoting Abstinence in General Internal Medicine. | Intern Med | 2026 | 42686576 | PubTator, text mining | PubMed |
| Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study. | Diabetes Obes Metab | 2026 | 42638160 | PubTator, text mining | PubMed |
| Estimating the Causal Effect of Alcohol Consumption on Military-Relevant Mental Health Conditions: A Mendelian Randomization Study Using the All of Us Research Program. | Mil Med | 2026 | 42565722 | PubTator, text mining | PubMed |
| Integrating machine learning, deep learning, and docking to predict aristolochic acid A carcinogenesis. | Front Pharmacol | 2026 | 42548907 | PubTator, text mining | PubMed |
| Association Between ADH1B rs1229984 Genetic Polymorphism and Hepatic Steatosis Assessed by CT Attenuation: A Mediation Analysis of Central Obesity in MASLD. | J Gastroenterol Hepatol | 2026 | 42548272 | PubTator, text mining | PubMed |
| Effect of ALDH2 rs671 and ADH1B rs1229984 polymorphisms on habitual alcohol use: evidence from a large Taiwanese cohort. | BJPsych Open | 2026 | 42478497 | PubTator, text mining | PubMed |
| History of Alcohol-Related Cancers and ADH1B/ALDH2 Genotypes in a Large Japanese Cohort of Male Patients With Alcohol Dependence. | Cancer Med | 2026 | 42415227 | PubTator, text mining | PubMed |
1 to 10 of 2,710
See all 2,710 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/125
GET https://conductscience.org/api/genes/v1/125/patents?page=2