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Gene · 125

ADH1B: alcohol dehydrogenase 1B (class I), beta polypeptide

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADH1B: alcohol dehydrogenase 1B (class I), beta polypeptide. Genes, record 125. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/125

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Gene

Symbol
ADH1B
HGNC
Name
alcohol dehydrogenase 1B (class I), beta polypeptide
HGNC
NCBI Gene ID
125
NCBI Gene
HGNC ID
HGNC:250
HGNC
Ensembl
ENSG00000196616
NCBI Gene
Aliases
ADH2, HEL-S-117
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P00325Alcohol dehydrogenase 1B3759Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436966P00325Espacenet
EP 4650780 A22025-11-194429P00325Espacenet
EP 4640849 A22025-10-293918P00325Espacenet
EP 4640849 A22025-10-29585P00325Espacenet
EP 4641201 A22025-10-2924347P00325Espacenet
EP 4641201 A22025-10-293976P00325Espacenet
JP 2025519096 A2025-06-24585P00325Espacenet
JP 2025519096 A2025-06-243918P00325Espacenet
JP 2025517969 A2025-06-123976P00325Espacenet
JP 2025517969 A2025-06-1224347P00325Espacenet

1 to 10 of 24

See all 24 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FOMEPIZOLECHEMBL1308Alcohol dehydrogenase class I inhibitorINHIBITORChEMBL
NITREFAZOLECHEMBL1909285Alcohol dehydrogenase inhibitorINHIBITORChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05517668FOMEPIZOLEPHASE2ClinicalTrials.gov
NCT00661141FOMEPIZOLEPHASE22017-09-15ClinicalTrials.gov
NCT00346853FOMEPIZOLEPHASE1ClinicalTrials.gov

NIH grants1,880

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADH1B papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).702025
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol332025
ZIAAA000301Integrative genetics of behavior with high throughput technologies202025
P50AA012870Center for the Translational Neuroscience of Alcoholism182025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors172025
UL1TR001863Yale Clinical and Translational Science Award172025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology152025
P30CA016672Cancer Center Support Grant112025
T32AA013525Alcohol Research in the Science/Practitioner Model82025
P30CA016086Cancer Center Support Grant72025

1 to 10 of 1,880Source NIH's project files

See all 1,880 nih grants

Papers2,710

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome-Wide Association Studies.Genet Epidemiol202642820398PubTator, text miningPubMed
Network toxicology and machine learning analysis of MC-LR-associated hepatocellular carcinoma.J Environ Sci Health B202642811799PubTator, text miningPubMed
ADH1B and ALDH2 polymorphisms and restless legs syndrome during pregnancy: A cross-sectional study during 2023-2025.Sleep Med202642715881PubTator, text miningPubMed
Teachable Moments in Alcohol-Related Diseases: A Practical Framework for Promoting Abstinence in General Internal Medicine.Intern Med202642686576PubTator, text miningPubMed
Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study.Diabetes Obes Metab202642638160PubTator, text miningPubMed
Estimating the Causal Effect of Alcohol Consumption on Military-Relevant Mental Health Conditions: A Mendelian Randomization Study Using the All of Us Research Program.Mil Med202642565722PubTator, text miningPubMed
Integrating machine learning, deep learning, and docking to predict aristolochic acid A carcinogenesis.Front Pharmacol202642548907PubTator, text miningPubMed
Association Between ADH1B rs1229984 Genetic Polymorphism and Hepatic Steatosis Assessed by CT Attenuation: A Mediation Analysis of Central Obesity in MASLD.J Gastroenterol Hepatol202642548272PubTator, text miningPubMed
Effect of ALDH2 rs671 and ADH1B rs1229984 polymorphisms on habitual alcohol use: evidence from a large Taiwanese cohort.BJPsych Open202642478497PubTator, text miningPubMed
History of Alcohol-Related Cancers and ADH1B/ALDH2 Genotypes in a Large Japanese Cohort of Male Patients With Alcohol Dependence.Cancer Med202642415227PubTator, text miningPubMed

1 to 10 of 2,710

See all 2,710 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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