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Gene · 126

ADH1C: alcohol dehydrogenase 1C (class I), gamma polypeptide

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADH1C: alcohol dehydrogenase 1C (class I), gamma polypeptide. Genes, record 126. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/126

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Gene

Symbol
ADH1C
HGNC
Name
alcohol dehydrogenase 1C (class I), gamma polypeptide
HGNC
NCBI Gene ID
126
NCBI Gene
HGNC ID
HGNC:251
HGNC
Ensembl
ENSG00000248144
NCBI Gene
Aliases
ADH3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P00326Alcohol dehydrogenase 1C3752Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2917658P00326Espacenet
JP 2025517969 A2025-06-1217658P00326Espacenet
JP 2025062604 A2025-04-143785P00326Espacenet
US 11446398 B22022-09-203785P00326Espacenet
JP 2022524081 A2022-04-27106756P00326Espacenet
JP 2022512897 A2022-02-0735P00326Espacenet
JP 2022502433 A2022-01-1135P00326Espacenet
JP 2022502435 A2022-01-1135P00326Espacenet
EP 3856207 A12021-08-0434P00326Espacenet
EP 3856241 A12021-08-0434P00326Espacenet

1 to 10 of 28

See all 28 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FOMEPIZOLECHEMBL1308Alcohol dehydrogenase class I inhibitorINHIBITORChEMBL
NITREFAZOLECHEMBL1909285Alcohol dehydrogenase inhibitorINHIBITORChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05517668FOMEPIZOLEPHASE2ClinicalTrials.gov
NCT00661141FOMEPIZOLEPHASE22017-09-15ClinicalTrials.gov
NCT00346853FOMEPIZOLEPHASE1ClinicalTrials.gov

NIH grants1,156

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADH1C papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).352025
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol162025
P50AA012870Center for the Translational Neuroscience of Alcoholism132025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology102025
ZIAAA000301Integrative genetics of behavior with high throughput technologies82025
DP1DA054394Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction62025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
R01HD081299Ontogeny of drug transport62025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors52025
UL1TR001863Yale Clinical and Translational Science Award52025

1 to 10 of 1,156Source NIH's project files

See all 1,156 nih grants

Papers1,405

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CYP1A2 and ADH1C contribute to abacavir aldehyde intermediate formation in the human liver.Drug Metab Dispos202642418947PubTator, text miningPubMed
Identification of alcohol dehydrogenase (ADH) isoforms catalyzing hydroxyzine oxidation using recombinant human ADH: Serendipitous finding of potent ADH inhibition by organic solvents.Drug Metab Dispos202642218107PubTator, text miningPubMed
[Ethanol promotes oxaliplatin resistance in colorectal cancer by activating the TGF‑β/Smad/P21 signaling axis].Nan Fang Yi Ke Da Xue Xue Bao202642198967PubTator, text miningPubMed
Integrated Bulk and Single-Cell Transcriptomic Analysis Reveals Xenobiotic Metabolism Genes Drive Progression From Liver Cirrhosis to Hepatocellular Carcinoma.Hum Mutat202642136961PubTator, text miningPubMed
Identification and validation of lactylation-related genes signature and immune infiltration landscape of rheumatoid arthritis based on machine learning.Hereditas202642135859PubTator, text miningPubMed
Associations Between Alcohol Dehydrogenase Mutations and Cleft Lip/Palate: A Scoping Review.Cleft Palate Craniofac J202641982202PubTator, text miningPubMed
Development of a triplex FMCA assay for genotyping three genes, ADH1B, ADH1C, and ALDH2, involved in alcohol metabolism.Sci Rep202641917132PubTator, text miningPubMed
Targeting metabolic dysregulation in HCC: Development and validation of a dual-biomarker diagnostic model integrating ADH1C and BHMT.Clin Res Hepatol Gastroenterol202641895659PubTator, text miningPubMed
MAGI3 deficiency unleashes β-catenin conformational change to drive metastatic progression and mTOR inhibitor resistance in ccRCC.Cell Death Dis202641876458PubTator, text miningPubMed
Integrating machine learning with SHAP to uncover multi-tissue molecular signatures in Osteoarthritis progression.PLoS One202641801977PubTator, text miningPubMed

1 to 10 of 1,405

See all 1,405 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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