Gene · 126
ADH1C: alcohol dehydrogenase 1C (class I), gamma polypeptide
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ADH1C: alcohol dehydrogenase 1C (class I), gamma polypeptide. Genes, record 126. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/126
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P00326 | Alcohol dehydrogenase 1C | 375 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 17658 | P00326 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 17658 | P00326 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3785 | P00326 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 3785 | P00326 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 106756 | P00326 | Espacenet |
| JP 2022512897 A | 2022-02-07 | 35 | P00326 | Espacenet |
| JP 2022502433 A | 2022-01-11 | 35 | P00326 | Espacenet |
| JP 2022502435 A | 2022-01-11 | 35 | P00326 | Espacenet |
| EP 3856207 A1 | 2021-08-04 | 34 | P00326 | Espacenet |
| EP 3856241 A1 | 2021-08-04 | 34 | P00326 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05517668 | FOMEPIZOLE | PHASE2 | ClinicalTrials.gov | |
| NCT00661141 | FOMEPIZOLE | PHASE2 | 2017-09-15 | ClinicalTrials.gov |
| NCT00346853 | FOMEPIZOLE | PHASE1 | ClinicalTrials.gov |
NIH grants1,156
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ADH1C papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 35 | 2025 |
| P60AA007611 | Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol | 16 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 13 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 10 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 8 | 2025 |
| DP1DA054394 | Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction | 6 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 6 | 2025 |
| R01HD081299 | Ontogeny of drug transport | 6 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
1 to 10 of 1,156Source NIH's project files
See all 1,156 nih grantsPapers1,405
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CYP1A2 and ADH1C contribute to abacavir aldehyde intermediate formation in the human liver. | Drug Metab Dispos | 2026 | 42418947 | PubTator, text mining | PubMed |
| Identification of alcohol dehydrogenase (ADH) isoforms catalyzing hydroxyzine oxidation using recombinant human ADH: Serendipitous finding of potent ADH inhibition by organic solvents. | Drug Metab Dispos | 2026 | 42218107 | PubTator, text mining | PubMed |
| [Ethanol promotes oxaliplatin resistance in colorectal cancer by activating the TGF‑β/Smad/P21 signaling axis]. | Nan Fang Yi Ke Da Xue Xue Bao | 2026 | 42198967 | PubTator, text mining | PubMed |
| Integrated Bulk and Single-Cell Transcriptomic Analysis Reveals Xenobiotic Metabolism Genes Drive Progression From Liver Cirrhosis to Hepatocellular Carcinoma. | Hum Mutat | 2026 | 42136961 | PubTator, text mining | PubMed |
| Identification and validation of lactylation-related genes signature and immune infiltration landscape of rheumatoid arthritis based on machine learning. | Hereditas | 2026 | 42135859 | PubTator, text mining | PubMed |
| Associations Between Alcohol Dehydrogenase Mutations and Cleft Lip/Palate: A Scoping Review. | Cleft Palate Craniofac J | 2026 | 41982202 | PubTator, text mining | PubMed |
| Development of a triplex FMCA assay for genotyping three genes, ADH1B, ADH1C, and ALDH2, involved in alcohol metabolism. | Sci Rep | 2026 | 41917132 | PubTator, text mining | PubMed |
| Targeting metabolic dysregulation in HCC: Development and validation of a dual-biomarker diagnostic model integrating ADH1C and BHMT. | Clin Res Hepatol Gastroenterol | 2026 | 41895659 | PubTator, text mining | PubMed |
| MAGI3 deficiency unleashes β-catenin conformational change to drive metastatic progression and mTOR inhibitor resistance in ccRCC. | Cell Death Dis | 2026 | 41876458 | PubTator, text mining | PubMed |
| Integrating machine learning with SHAP to uncover multi-tissue molecular signatures in Osteoarthritis progression. | PLoS One | 2026 | 41801977 | PubTator, text mining | PubMed |
1 to 10 of 1,405
See all 1,405 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/126
GET https://conductscience.org/api/genes/v1/126/patents?page=2