ConductScience.org, home

Gene · 1282

COL4A1: collagen type IV alpha 1 chain

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. COL4A1: collagen type IV alpha 1 chain. Genes, record 1282. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1282

On this page

Gene

Symbol
COL4A1
HGNC
Name
collagen type IV alpha 1 chain
HGNC
NCBI Gene ID
1282
NCBI Gene
HGNC ID
HGNC:2202
HGNC
Ensembl
ENSG00000187498
NCBI Gene
Aliases
BSVD, BSVD1, COL4A1s, PADMAL, RATOR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P02462Collagen alpha-1(IV) chain1,6694Ensembl, GeneID, HGNC

Source UniProt

Patents78

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21393P02462Espacenet
JP 2026042028 A2026-03-1018P02462Espacenet
EP 4694927 A12026-02-1826P02462Espacenet
EP 4650780 A22025-11-199692P02462Espacenet
EP 4641201 A22025-10-299950P02462Espacenet
JP 2025147176 A2025-10-063290P02462Espacenet
JP 2025529142 A2025-09-045952P02462Espacenet
US 12371689 B22025-07-295952P02462Espacenet
JP 2025517969 A2025-06-129950P02462Espacenet
JP 2025517970 A2025-06-129692P02462Espacenet

1 to 10 of 78

See all 78 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants2,514

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL4A1 papersNewest fiscal year
R01EY019887Genetically testing mechanisms of ocular development and disease92025
UL1TR001863Yale Clinical and Translational Science Award92025
P30CA016672Cancer Center Support Grant82025
P30CA033572Cancer Center Support Grant72025
R01DK018381Studies on the structure of basement membranes72025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal62025
R01NS017950Precursors of Stroke Incidence and Prognosis62025
P30AG072975Rush Alzheimer's Disease Research Center52025
P30CA062203Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)52025

1 to 10 of 2,514Source NIH's project files

See all 2,514 nih grants

Papers3,934

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Unraveling tumor cell heterogeneity and epithelial-mesenchymal plasticity in gastric adenocarcinoma: an integrative multi-omics framework evaluating PVR/CD155 as a tumor cell-intrinsic EMT-associated target.
Front Immunol202642769440PubTator, text miningPubMed
Fetal Intracranial Hemorrhage: What to Tell Expecting Parents?Prenat Diagn202642762541PubTator, text miningPubMed
Family partnership as a foundation for future international COL4A1 and COL4A2 research.Dev Med Child Neurol202642748458PubTator, text miningPubMed
The molecular landscape of hypertrophic cardiomyopathy across disease stages and genotypes.Sci Transl Med202642748219PubTator, text miningPubMed
A Rare Case of Gould Syndrome Presenting With Gastrointestinal Bleeding in a Pediatric Patient.Cureus202642746649PubTator, text miningPubMed
Single-cell and spatial transcriptomic profiling identifies a fibroblast-like endothelial state and the MDK-NCL signaling axis in prostate cancer microenvironment remodeling.Transl Oncol202642669284PubTator, text miningPubMed
Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease.Clin Genet202642661427PubTator, text miningPubMed
An Integrative Bioinformatics Framework Nominates Candidate Limbal Stem-Cell Exosome Cargo for Keratoconus by Coupling Corneal Transcriptomics, Disease-Gene Evidence and Extracellular-Vesicle Repositories.
Bioengineering (Basel)202642649743PubTator, text miningPubMed
Exploring Matrix Stiffness-Related Gene in Periodontitis: A Comprehensive Multidataset Analysis.Mediators Inflamm202642644235PubTator, text miningPubMed
Quercetin and lupeol accelerate keratinocyte wound healing by dual modulation of GLP-1 receptor activity and stability.Life Sci202642637031PubTator, text miningPubMed

1 to 10 of 3,934

See all 3,934 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1282

GET https://conductscience.org/api/genes/v1/1282/patents?page=2