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Gene · 1285

COL4A3: collagen type IV alpha 3 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL4A3: collagen type IV alpha 3 chain. Genes, record 1285. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1285

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Gene

Symbol
COL4A3
HGNC
Name
collagen type IV alpha 3 chain
HGNC
NCBI Gene ID
1285
NCBI Gene
HGNC ID
HGNC:2204
HGNC
Ensembl
ENSG00000169031
NCBI Gene
Aliases
ATS2, ATS3, ATS3A, ATS3B, BFH2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01955Collagen alpha-3(IV) chain1,6702Ensembl, GeneID, HGNC

Source UniProt

Patents103

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11494Q01955Espacenet
WO 2025253101 A12025-12-1112Q01955Espacenet
JP 2025539119 A2025-12-034Q01955Espacenet
EP 4650780 A22025-11-1911400Q01955Espacenet
EP 4640849 A22025-10-291785Q01955Espacenet
EP 4641201 A22025-10-2911929Q01955Espacenet
JP 2025147176 A2025-10-063298Q01955Espacenet
JP 2025529142 A2025-09-045954Q01955Espacenet
US 12371689 B22025-07-295954Q01955Espacenet
KR 1020250112259 A2025-07-234Q01955Espacenet

1 to 10 of 103

See all 103 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants1,039

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL4A3 papersNewest fiscal year
R01DK018381Studies on the structure of basement membranes132025
U01HG008680EHR-based Genome-Informed Risk Assessment and Communication62025
P30DK020579Diabetes Research Center52025
P30EY000331Vision Research Core at UCLA52025
U01DK1161011-13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical Center52025
R01DK104753Crosstalk Between Lipid Droplets and Other Organelles in Podocytes42025
T32GM139776Medical Scientist Training Program42025
I01BX002025Molecular Mechanisms of Kidney Fibrosis32025
P30CA016672Cancer Center Support Grant32025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center32025

1 to 10 of 1,039Source NIH's project files

See all 1,039 nih grants

Papers2,040

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Heterozygous COL4A3/COL4A4 variants: diagnostic trends and clinical kidney outcomes.Clin Kidney J202642824368PubTator, text miningPubMed
Probable autosomal dominant Alport syndrome associated with a novel COL4A4 variant: A case report.Mol Genet Metab Rep202642774990PubTator, text miningPubMed
COL4A3 promotes invasion and acts as a biomarker in pituitary neuroendocrine tumor.Endocr Relat Cancer202642766391PubTator, text miningPubMed
Exome Sequencing in Patients with Loin Pain Hematuria Syndrome and Persistent Isolated Hematuria.Kidney Int Rep202642751148PubTator, text miningPubMed
Considering Heterozygous Variants in COL4A3, COL4A4, COL4A5: Genetic Features and Clinical Outcomes.Kidney360202642658539PubTator, text miningPubMed
Kidney Transcriptome Sequencing Improves Molecular Diagnosis and Reveals Splicing Complexity Across the Alport Spectrum.Kidney Int Rep202642614610PubTator, text miningPubMed
Pediatric hematuria as a gateway to family genetic investigation in type IV collagen nephropathies: experience from a regional cohort.J Nephrol202642552945PubTator, text miningPubMed
An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid.bioRxiv202642539169PubTator, text miningPubMed
A single-nucleus transcriptomic characterization of EGFR G719X/S768I double-mutant lung adenocarcinoma identifies an immunosuppressive niche defined by COL4A3-CD44 interaction.Transl Oncol202642531730PubTator, text miningPubMed
Integrated network toxicology and bioinformatics approaches explore potential mechanisms linking organophosphate flame retardant exposure to rheumatoid arthritis.Mol Divers202642530799PubTator, text miningPubMed

1 to 10 of 2,040

See all 2,040 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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