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Gene · 1286

COL4A4: collagen type IV alpha 4 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL4A4: collagen type IV alpha 4 chain. Genes, record 1286. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1286

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Gene

Symbol
COL4A4
HGNC
Name
collagen type IV alpha 4 chain
HGNC
NCBI Gene ID
1286
NCBI Gene
HGNC ID
HGNC:2206
HGNC
Ensembl
ENSG00000081052
NCBI Gene
Aliases
ATS2, BFH, BFH1, CA44
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P53420Collagen alpha-4(IV) chain1,6902Ensembl, GeneID, HGNC

Source UniProt

Patents78

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11495P53420Espacenet
WO 2025253101 A12025-12-1113P53420Espacenet
JP 2025539119 A2025-12-035P53420Espacenet
EP 4641201 A22025-10-2911935P53420Espacenet
JP 2025147176 A2025-10-063300P53420Espacenet
JP 2025140989 A2025-09-295P53420Espacenet
JP 2025529142 A2025-09-045955P53420Espacenet
US 12371689 B22025-07-295955P53420Espacenet
KR 1020250112259 A2025-07-235P53420Espacenet
JP 2025517969 A2025-06-1211935P53420Espacenet

1 to 10 of 78

See all 78 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
TRC-093CHEMBL2109374Collagen alpha-4(IV) chain inhibitorINHIBITORChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants697

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL4A4 papersNewest fiscal year
R01DK018381Studies on the structure of basement membranes112025
U01HG008680EHR-based Genome-Informed Risk Assessment and Communication62025
P30DK020579Diabetes Research Center42025
R01DK128660Innovative Approaches to Treating Alport Syndrome42025
I01BX002025Molecular Mechanisms of Kidney Fibrosis32025
P30CA076292Moffitt Cancer Center Support Grant32025
R25DK096999Undergraduate Discovery Science Experience in Renal Biology and Disease32025
I01BX002196lntegrin binding proteins and the kidney22025
K25DK128563Predictive utility of polygenic risk scores for chronic kidney disease.22025
KL2TR001874Institutional Career Development Core22025

1 to 10 of 697Source NIH's project files

See all 697 nih grants

Papers1,462

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Heterozygous COL4A3/COL4A4 variants: diagnostic trends and clinical kidney outcomes.Clin Kidney J202642824368PubTator, text miningPubMed
Autosomal recessive Alport syndrome associated with two heterozygous COL4A4 variants.Pathol Res Pract202642800361PubTator, text miningPubMed
Probable autosomal dominant Alport syndrome associated with a novel COL4A4 variant: A case report.Mol Genet Metab Rep202642774990PubTator, text miningPubMed
Exome Sequencing in Patients with Loin Pain Hematuria Syndrome and Persistent Isolated Hematuria.Kidney Int Rep202642751148PubTator, text miningPubMed
Considering Heterozygous Variants in COL4A3, COL4A4, COL4A5: Genetic Features and Clinical Outcomes.Kidney360202642658539PubTator, text miningPubMed
Prognostic and immunological value of LINC01615-related genes in kidney clear cell carcinoma: Integrated bioinformatics analysis and expression validation.Medicine (Baltimore)202642629666PubTator, text miningPubMed
Kidney Transcriptome Sequencing Improves Molecular Diagnosis and Reveals Splicing Complexity Across the Alport Spectrum.Kidney Int Rep202642614610PubTator, text miningPubMed
Epigenetic inactivation of COL4A4 orchestrates JAK2/STAT3-driven progression and microenvironment reprogramming in renal cell carcinoma.Int Immunopharmacol202642612346PubTator, text miningPubMed
Pediatric hematuria as a gateway to family genetic investigation in type IV collagen nephropathies: experience from a regional cohort.J Nephrol202642552945PubTator, text miningPubMed
Knowledge Mapping of Alport Syndrome: A Bibliometric Analysis From 2000 to 2025.Mol Genet Genomic Med202642464065PubTator, text miningPubMed

1 to 10 of 1,462

See all 1,462 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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