Gene · 1286
COL4A4: collagen type IV alpha 4 chain
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. COL4A4: collagen type IV alpha 4 chain. Genes, record 1286. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1286
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P53420 | Collagen alpha-4(IV) chain | 1,690 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents78
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4705273 A2 | 2026-03-11 | 495 | P53420 | Espacenet |
| WO 2025253101 A1 | 2025-12-11 | 13 | P53420 | Espacenet |
| JP 2025539119 A | 2025-12-03 | 5 | P53420 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11935 | P53420 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3300 | P53420 | Espacenet |
| JP 2025140989 A | 2025-09-29 | 5 | P53420 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5955 | P53420 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5955 | P53420 | Espacenet |
| KR 1020250112259 A | 2025-07-23 | 5 | P53420 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11935 | P53420 | Espacenet |
1 to 10 of 78
See all 78 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials66
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06169319 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | PHASE2 | ClinicalTrials.gov | |
| NCT06151197 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | PHASE3 | ClinicalTrials.gov | |
| NCT06065436 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | ClinicalTrials.gov | ||
| NCT05646602 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | ClinicalTrials.gov | ||
| NCT05254457 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | PHASE3 | ClinicalTrials.gov | |
| NCT05152173 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | PHASE2 | ClinicalTrials.gov | |
| NCT04874870 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | PHASE3 | ClinicalTrials.gov | |
| NCT04680156 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | ClinicalTrials.gov | ||
| NCT04496167 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | PHASE2 | 2023-09-13 | ClinicalTrials.gov |
| NCT04236635 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM | PHASE2 | 2022-04-12 | ClinicalTrials.gov |
1 to 10 of 66
See all 66 trialsNIH grants697
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | COL4A4 papers | Newest fiscal year |
|---|---|---|---|
| R01DK018381 | Studies on the structure of basement membranes | 11 | 2025 |
| U01HG008680 | EHR-based Genome-Informed Risk Assessment and Communication | 6 | 2025 |
| P30DK020579 | Diabetes Research Center | 4 | 2025 |
| R01DK128660 | Innovative Approaches to Treating Alport Syndrome | 4 | 2025 |
| I01BX002025 | Molecular Mechanisms of Kidney Fibrosis | 3 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| R25DK096999 | Undergraduate Discovery Science Experience in Renal Biology and Disease | 3 | 2025 |
| I01BX002196 | lntegrin binding proteins and the kidney | 2 | 2025 |
| K25DK128563 | Predictive utility of polygenic risk scores for chronic kidney disease. | 2 | 2025 |
| KL2TR001874 | Institutional Career Development Core | 2 | 2025 |
1 to 10 of 697Source NIH's project files
See all 697 nih grantsPapers1,462
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Heterozygous COL4A3/COL4A4 variants: diagnostic trends and clinical kidney outcomes. | Clin Kidney J | 2026 | 42824368 | PubTator, text mining | PubMed |
| Autosomal recessive Alport syndrome associated with two heterozygous COL4A4 variants. | Pathol Res Pract | 2026 | 42800361 | PubTator, text mining | PubMed |
| Probable autosomal dominant Alport syndrome associated with a novel COL4A4 variant: A case report. | Mol Genet Metab Rep | 2026 | 42774990 | PubTator, text mining | PubMed |
| Exome Sequencing in Patients with Loin Pain Hematuria Syndrome and Persistent Isolated Hematuria. | Kidney Int Rep | 2026 | 42751148 | PubTator, text mining | PubMed |
| Considering Heterozygous Variants in COL4A3, COL4A4, COL4A5: Genetic Features and Clinical Outcomes. | Kidney360 | 2026 | 42658539 | PubTator, text mining | PubMed |
| Prognostic and immunological value of LINC01615-related genes in kidney clear cell carcinoma: Integrated bioinformatics analysis and expression validation. | Medicine (Baltimore) | 2026 | 42629666 | PubTator, text mining | PubMed |
| Kidney Transcriptome Sequencing Improves Molecular Diagnosis and Reveals Splicing Complexity Across the Alport Spectrum. | Kidney Int Rep | 2026 | 42614610 | PubTator, text mining | PubMed |
| Epigenetic inactivation of COL4A4 orchestrates JAK2/STAT3-driven progression and microenvironment reprogramming in renal cell carcinoma. | Int Immunopharmacol | 2026 | 42612346 | PubTator, text mining | PubMed |
| Pediatric hematuria as a gateway to family genetic investigation in type IV collagen nephropathies: experience from a regional cohort. | J Nephrol | 2026 | 42552945 | PubTator, text mining | PubMed |
| Knowledge Mapping of Alport Syndrome: A Bibliometric Analysis From 2000 to 2025. | Mol Genet Genomic Med | 2026 | 42464065 | PubTator, text mining | PubMed |
1 to 10 of 1,462
See all 1,462 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1286
GET https://conductscience.org/api/genes/v1/1286/patents?page=2