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Gene · 1287

COL4A5: collagen type IV alpha 5 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL4A5: collagen type IV alpha 5 chain. Genes, record 1287. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1287

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Gene

Symbol
COL4A5
HGNC
Name
collagen type IV alpha 5 chain
HGNC
NCBI Gene ID
1287
NCBI Gene
HGNC ID
HGNC:2207
HGNC
Ensembl
ENSG00000188153
NCBI Gene
Aliases
ASLN, ATS, ATS1, CA54
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29400Collagen alpha-5(IV) chain1,6852Ensembl, GeneID, HGNC

Source UniProt

Patents93

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11496P29400Espacenet
WO 2025253101 A12025-12-1114P29400Espacenet
JP 2025539119 A2025-12-036P29400Espacenet
EP 4650780 A22025-11-197875P29400Espacenet
EP 4641201 A22025-10-297976P29400Espacenet
JP 2025147176 A2025-10-063305P29400Espacenet
JP 2025529142 A2025-09-045956P29400Espacenet
US 12371689 B22025-07-295956P29400Espacenet
KR 1020250112259 A2025-07-236P29400Espacenet
JP 2025517969 A2025-06-127976P29400Espacenet

1 to 10 of 93

See all 93 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants870

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL4A5 papersNewest fiscal year
R01DK018381Studies on the structure of basement membranes82025
U01HG008680EHR-based Genome-Informed Risk Assessment and Communication62025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P30DK020579Diabetes Research Center42025
UL1TR001863Yale Clinical and Translational Science Award42025
ZICAG000616Analysis of complex biological systems by high-throughput genomic technologies42025
I01BX002025Molecular Mechanisms of Kidney Fibrosis32025
P30CA042014Cancer Center Support Grant32025

1 to 10 of 870Source NIH's project files

See all 870 nih grants

Papers2,056

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Functional characterization of genetic variants associated with rare inherited renal disorders in the Sri Lankan population.Mol Genet Genomics202642814169PubTator, text miningPubMed
Probable autosomal dominant Alport syndrome associated with a novel COL4A4 variant: A case report.Mol Genet Metab Rep202642774990PubTator, text miningPubMed
Exome Sequencing in Patients with Loin Pain Hematuria Syndrome and Persistent Isolated Hematuria.Kidney Int Rep202642751148PubTator, text miningPubMed
Considering Heterozygous Variants in COL4A3, COL4A4, COL4A5: Genetic Features and Clinical Outcomes.Kidney360202642658539PubTator, text miningPubMed
Kidney Transcriptome Sequencing Improves Molecular Diagnosis and Reveals Splicing Complexity Across the Alport Spectrum.Kidney Int Rep202642614610PubTator, text miningPubMed
Pediatric hematuria as a gateway to family genetic investigation in type IV collagen nephropathies: experience from a regional cohort.J Nephrol202642552945PubTator, text miningPubMed
Knowledge Mapping of Alport Syndrome: A Bibliometric Analysis From 2000 to 2025.Mol Genet Genomic Med202642464065PubTator, text miningPubMed
Case Report: a novel non-canonical splice site variant in COL4A5 in a patient with Alport syndrome.Front Med (Lausanne)202642404581PubTator, text miningPubMed
Anti-Glomerular Basement Membrane Nephritis Post-Renal Transplant in Alport Syndrome Patients.Kidney360202642390934PubTator, text miningPubMed
Clinical impact of genetic testing in inherited kidney diseases.Clin Kidney J202642389199PubTator, text miningPubMed

1 to 10 of 2,056

See all 2,056 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/1287/patents?page=2