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Gene · 1290

COL5A2: collagen type V alpha 2 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL5A2: collagen type V alpha 2 chain. Genes, record 1290. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1290

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Gene

Symbol
COL5A2
HGNC
Name
collagen type V alpha 2 chain
HGNC
NCBI Gene ID
1290
NCBI Gene
HGNC ID
HGNC:2210
HGNC
Ensembl
ENSG00000204262
NCBI Gene
Aliases
EDSC, EDSCL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05997Collagen alpha-2(V) chain1,4990Ensembl, GeneID, HGNC

Source UniProt

Patents85

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11500P05997Espacenet
EP 4650780 A22025-11-199538P05997Espacenet
EP 4641201 A22025-10-299791P05997Espacenet
JP 2025147176 A2025-10-063318P05997Espacenet
JP 2025529142 A2025-09-045959P05997Espacenet
US 12371689 B22025-07-295959P05997Espacenet
JP 2025517969 A2025-06-129791P05997Espacenet
JP 2025517970 A2025-06-129538P05997Espacenet
JP 2025028160 A2025-02-283318P05997Espacenet
JP 2025013347 A2025-01-2473P05997Espacenet

1 to 10 of 85

See all 85 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants1,169

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL5A2 papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award82025
P20GM103408Idaho INBRE Program42025
P30CA068485Cancer Center Support Grant42025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition42025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 532025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA047904Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
P30CA168524The University of Kansas Cancer Center32025
P30ES025128Center for Human Health and the Environment (CHHE)32025

1 to 10 of 1,169Source NIH's project files

See all 1,169 nih grants

Papers2,039

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effect of the unreported COL5A2 variant c.2499 + 4_2499 + 5insTAA on RNA splicing: Insights from minigene assays.Clin Chim Acta202742594983PubTator, text miningPubMed
Tumor FAK supports fibrillar collagen expression in ovarian cancer ascites.Matrix Biol202642753930PubTator, text miningPubMed
[Transcriptomic analysis of NT5E/CD73-related macrophage state remodeling in the maternal-fetal immune microenvironment of recurrent pregnancy loss].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi202642750328PubTator, text miningPubMed
METTL3-Mediated m6A Modification of COL5A2 Inhibits Ferroptosis Through an IGF2BP3-dependent Mechanism in Gastric Cancer.Technol Cancer Res Treat202642663553PubTator, text miningPubMed
CircRNA hsa_circ_0001946 promotes hypertrophic scar pathogenesis via the miR-514a-3p/COL5A2 axis.Pathol Res Pract202642561881PubTator, text miningPubMed
The therapy-induced senescence-associated secretory phenotype and epithelial-mesenchymal transition axis in ovarian cancer: molecular mechanisms and therapeutic opportunities.Expert Opin Ther Targets202642528374PubTator, text miningPubMed
Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways.Aesthetic Plast Surg202642414644PubTator, text miningPubMed
Integrated transcriptomic and proteomic profiling in keloid tissue.PeerJ202642369759PubTator, text miningPubMed
Transcriptomic profiling of collagen gene expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.Sarcoidosis Vasc Diffuse Lung Dis202642329017PubTator, text miningPubMed
Collagen gene expression profiles predict recurrence and progression of DCIS to IDC.Sci Rep202642288681PubTator, text miningPubMed

1 to 10 of 2,039

See all 2,039 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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