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Gene · 1291

COL6A1: collagen type VI alpha 1 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL6A1: collagen type VI alpha 1 chain. Genes, record 1291. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1291

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Gene

Symbol
COL6A1
HGNC
Name
collagen type VI alpha 1 chain
HGNC
NCBI Gene ID
1291
NCBI Gene
HGNC ID
HGNC:2211
HGNC
Ensembl
ENSG00000142156
NCBI Gene
Aliases
BTHLM1, BTHLM1A, OPLL, UCHMD1, UCHMD1A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P12109Collagen alpha-1(VI) chain1,0281Ensembl, GeneID, HGNC

Source UniProt

Patents90

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026042028 A2026-03-1019P12109Espacenet
JP 2026004568 A2026-01-1441877P12109Espacenet
EP 4650780 A22025-11-198020P12109Espacenet
EP 4641201 A22025-10-298134P12109Espacenet
EP 4641203 A22025-10-29230P12109Espacenet
JP 2025147176 A2025-10-063321P12109Espacenet
JP 2025529142 A2025-09-045961P12109Espacenet
US 12371689 B22025-07-295961P12109Espacenet
JP 2025517967 A2025-06-12230P12109Espacenet
JP 2025517969 A2025-06-128134P12109Espacenet

1 to 10 of 90

See all 90 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants1,542

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL6A1 papersNewest fiscal year
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies342025
P30CA008748Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
P30AR075047Skin Biology Resource-Based Center at UCI32025
P30CA062203Cancer Center Support Grant32025
P30DK089503Michigan Nutrition Obesity Research Center32025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)32025
P30EY010572Ophthalmology Core Facility32025
ZICES102445Gene Expression and Microarrays32025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025

1 to 10 of 1,542Source NIH's project files

See all 1,542 nih grants

Papers2,357

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Triple-Frequency Electromagnetic Stimulation Combined with Fingolimod Reduces Breast Cancer Cell Proliferation and Metastasis-Associated Extracellular Vesicle Protein Levels.Pharmaceuticals (Basel)202642797444PubTator, text miningPubMed
[Transcriptomic analysis of NT5E/CD73-related macrophage state remodeling in the maternal-fetal immune microenvironment of recurrent pregnancy loss].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi202642750328PubTator, text miningPubMed
Type VI collagen is proportionally lower around airways and blood vessels in idiopathic pulmonary fibrosis.Am J Physiol Cell Physiol202642743047PubTator, text miningPubMed
Matrix Architecture and Integrin Branch Balance Distinguish Immune-Regulatory States in Clear Cell Renal Cell Carcinoma.Curr Issues Mol Biol202642651788PubTator, text miningPubMed
Spatial Transcriptomics of Micropapillary, Plasmacytoid, and Sarcomatoid Urothelial Carcinoma Reveals Distinct Molecular Landscapes.Lab Invest202642641761PubTator, text miningPubMed
Nanofibrous Matrices Modulating Glioma Cell Migration and Proliferation and the Exploration of Their Molecular Mechanism.ACS Appl Bio Mater202642606053PubTator, text miningPubMed
The Biological Response of Human NP Cells to Soluble Collagen VI.Cells202642587749PubTator, text miningPubMed
Whole-Exome Sequencing in Undiagnosed Muscular Dystrophies: A High Diagnostic Yield and Novel Insights From Iranian Families.Hum Mutat202642553504PubTator, text miningPubMed
Prednisone, not vamorolone, suppresses novel serum bone and cartilage biomarkers associated with growth failure in children with Duchenne muscular dystrophy.Sci Rep202642547787PubTator, text miningPubMed
Urinary proteomic signature of exercise intolerance in patients at risk of heart failure: evidence from the HOMAGE trial.EBioMedicine202642531722PubTator, text miningPubMed

1 to 10 of 2,357

See all 2,357 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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