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Gene · 1293

COL6A3: collagen type VI alpha 3 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL6A3: collagen type VI alpha 3 chain. Genes, record 1293. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1293

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Gene

Symbol
COL6A3
HGNC
Name
collagen type VI alpha 3 chain
HGNC
NCBI Gene ID
1293
NCBI Gene
HGNC ID
HGNC:2213
HGNC
Ensembl
ENSG00000163359
NCBI Gene
Aliases
BTHLM1, BTHLM1C, DYT27, UCMD1, UCMD1C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P12111Collagen alpha-3(VI) chain3,1776Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193625P12111Espacenet
EP 4640849 A22025-10-29466P12111Espacenet
EP 4641201 A22025-10-293220P12111Espacenet
US 12433933 B22025-10-0713P12111Espacenet
JP 2025147176 A2025-10-063332P12111Espacenet
JP 2025529142 A2025-09-045963P12111Espacenet
US 12371689 B22025-07-295963P12111Espacenet
JP 2025519096 A2025-06-24466P12111Espacenet
JP 2025517969 A2025-06-123220P12111Espacenet
JP 2025517970 A2025-06-123625P12111Espacenet

1 to 10 of 63

See all 63 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants1,534

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL6A3 papersNewest fiscal year
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies292025
P30CA008748Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant72025
R01DK099110White Adipose Tissue Physiology, Mitochondrial Function and Adiponectin52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center42025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors42025
R01DK117850Systems Genetics Dissection of Non-alcoholic Steatohepatitis42025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center32025
P30CA013148Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,534Source NIH's project files

See all 1,534 nih grants

Papers2,433

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Airway cell-cell communication in smoking through integration of spatial and single-cell transcriptomics.Respir Res202642827249PubTator, text miningPubMed
Exploring Molecular Pathways in Metastasis of Breast Cancer Cells to the Brain: Insights from Gene Expression Analysis and Cellular Origins.J Microsc Ultrastruct202642824931PubTator, text miningPubMed
Gapmer and Mixmer Antisense Oligonucleotides to Selectively Suppress the Mutant Allele in COL6A Genes in Dominant Ullrich Congenital Muscular Dystrophy.Methods Mol Biol202642814309PubTator, text miningPubMed
Isocyanate-Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3-Mediated Extracellular Matrix Remodeling and cGAS-STING Pathway Activation in Bladder Cancer.Adv Sci (Weinh)202642801591PubTator, text miningPubMed
Triple-Frequency Electromagnetic Stimulation Combined with Fingolimod Reduces Breast Cancer Cell Proliferation and Metastasis-Associated Extracellular Vesicle Protein Levels.Pharmaceuticals (Basel)202642797444PubTator, text miningPubMed
Bioinformatics analysis and experimental validation confirm COL6A3 as a promising target for renal cell carcinoma therapy.Transl Androl Urol202642729068PubTator, text miningPubMed
Cell surface CD11c as a neutrophil aging marker molecule.FEBS Open Bio202642675867PubTator, text miningPubMed
Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids.bioRxiv202642620194PubTator, text miningPubMed
IL-1β-Induced Inflammatory Transcriptome and TGF-β1 Attenuation of Chemokine Expression in ACL Remnant Fibroblasts.Am J Sports Med202642606104PubTator, text miningPubMed
Longitudinal Evolution and Cellular Plasticity in Meningioma: Insights From Single-Cell Transcriptomics.Brain Tumor Res Treat202642543809PubTator, text miningPubMed

1 to 10 of 2,433

See all 2,433 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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