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Gene · 1301

COL11A1: collagen type XI alpha 1 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL11A1: collagen type XI alpha 1 chain. Genes, record 1301. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1301

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Gene

Symbol
COL11A1
HGNC
Name
collagen type XI alpha 1 chain
HGNC
NCBI Gene ID
1301
NCBI Gene
HGNC ID
HGNC:2186
HGNC
Ensembl
ENSG00000060718
NCBI Gene
Aliases
CO11A1, COLL6, DFNA37, STL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P12107Collagen alpha-1(XI) chain1,8060Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-1934P12107Espacenet
EP 4650780 A22025-11-198722P12107Espacenet
EP 4640849 A22025-10-291324P12107Espacenet
EP 4641201 A22025-10-298919P12107Espacenet
JP 2025147176 A2025-10-063208P12107Espacenet
JP 2025529142 A2025-09-045933P12107Espacenet
US 12371689 B22025-07-295933P12107Espacenet
JP 2025519096 A2025-06-241324P12107Espacenet
JP 2025517969 A2025-06-128919P12107Espacenet
JP 2025517970 A2025-06-128722P12107Espacenet

1 to 10 of 39

See all 39 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants1,272

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL11A1 papersNewest fiscal year
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center82025
P30CA008748Cancer Center Support Grant82025
P20GM103408Idaho INBRE Program72025
P30EY014104P30 Core Grant for Vision Research62025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer62025
P01HD084387Developmental Mechanisms of Human Idiopathic Scoliosis52025
R01AI022553Molecular Analysis of Host Immune Response in Leprosy52025
R01AR040312CD1-restricted T-cell Responses in Skin52025
P30CA016672Cancer Center Support Grant42025
P30EY010572Ophthalmology Core Facility42025

1 to 10 of 1,272Source NIH's project files

See all 1,272 nih grants

Papers2,518

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
COL11A1-packaged extracellular vesicles from THY1+ cancer-associated fibroblasts confer oxaliplatin resistance and unfavorable prognosis in gastric cancer.Biochim Biophys Acta Mol Basis Dis202742628770PubTator, text miningPubMed
Construction of an Esophageal Cancer Prognostic Model Based on Mitochondrial Energy Metabolism-Related Genes and Mechanism of INHBA in Promoting Malignant Progression via the Smad2/3 Pathway.Biomolecules202642793200PubTator, text miningPubMed
Genetic findings and clinical features of extreme refractive errors in Thai children using whole genome sequencing.Ophthalmic Genet202642755333PubTator, text miningPubMed
Spatial dynamics of cancer-associated fibroblasts links fibroblastic differentiation to immune exclusion and tumor progression.Front Immunol202642729505PubTator, text miningPubMed
Biological Characteristics of Stromal Cells Differ Between Primary Lung Adenocarcinoma, Peritumoral Lung, and Distal Lung Tissues.Stem Cells Int202642712869PubTator, text miningPubMed
Compartment-Specific Immunohistochemical Alterations Along the Colorectal Adenoma-Carcinoma Continuum.Dig Dis Sci202642606680PubTator, text miningPubMed
Unveiling differential gene expression and pathways in clear cell renal cell carcinoma with sarcomatoid transformation.PeerJ202642569572PubTator, text miningPubMed
Diagnostic Yield of Genetic Disorders in Children with Hip Dysplasia Mimicking Bilateral Legg-Calvé-Perthes Disease.Diagnostics (Basel)202642510156PubTator, text miningPubMed
MRPL13 sustains mitochondrial integrity and MAPK-associated aggressiveness in esophageal squamous cell carcinoma.Cancer Cell Int202642469813PubTator, text miningPubMed
The PLAU-ITGB1-TGF-β axis orchestrates spatiotemporal reprogramming of fibroblasts at the invasive front to drive dual immunosuppressive niche and immunotherapy resistance in oral squamous cell carcinoma.
Cell Death Dis202642463632PubTator, text miningPubMed

1 to 10 of 2,518

See all 2,518 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1301

GET https://conductscience.org/api/genes/v1/1301/patents?page=2